TSN — 14 ClinVar variants
All ClinVar germline TSN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 13 flagged for review →
1 Likely benign · 13 Uncertain significance
Full TSN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 13
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 11
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSN p.Ala223Val Uncertain significance Single submitter
- TSN p.Asp128Gly Uncertain significance Single submitter
- TSN p.Asp211Gly Uncertain significance Single submitter
- TSN p.Glu126Ala Uncertain significance Single submitter
- TSN p.Gly66Val Uncertain significance Single submitter
- TSN p.Ile6Phe Uncertain significance Single submitter
- TSN p.Leu184Phe Uncertain significance Single submitter
- TSN p.Ser74Cys Uncertain significance Single submitter
- TSN p.Tyr195Cys Uncertain significance Single submitter
- TSN p.Val156Gly Uncertain significance Single submitter
- TSN p.Val8Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All TSN variants
Likely benign 1
- p.Asp196= Single submitter
Uncertain significance 13
- p.Ala223Val Single submitter ⚠
- p.Asp128Gly Single submitter ⚠
- p.Asp211Gly Single submitter ⚠
- p.Glu126Ala Single submitter ⚠
- p.Glu17Gly Single submitter ⚠
- p.Glu23Lys Single submitter ⚠
- p.Gly66Val Single submitter ⚠
- p.Ile6Phe Single submitter ⚠
- p.Leu184Phe Single submitter ⚠
- p.Ser74Cys Single submitter ⚠
- p.Tyr195Cys Single submitter ⚠
- p.Val156Gly Single submitter ⚠
- p.Val8Met Single submitter ⚠