TSPO — 20 ClinVar variants
All ClinVar germline TSPO variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
8 Likely benign · 12 Uncertain significance
Full TSPO gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSPO p.Ala59Thr Uncertain significance Single submitter
- TSPO p.Arg24His Uncertain significance Single submitter
- TSPO p.Arg32His Uncertain significance Single submitter
- TSPO p.Cys153Tyr Uncertain significance Single submitter
- TSPO p.Gln128Leu Uncertain significance Single submitter
- TSPO p.Gly72Glu Uncertain significance Single submitter
- TSPO p.His159Tyr Uncertain significance Single submitter
- TSPO p.Phe99Ser Uncertain significance Single submitter
- TSPO p.Thr122Ser Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All TSPO variants
Likely benign 8
- p.Ala14Val Single submitter
- p.Cys153= Single submitter
- p.His159Arg Single submitter
- p.Leu137= Single submitter
- p.Leu141= Single submitter
- p.Pro131= Single submitter
- p.Thr123= Single submitter
- p.Thr147= Single submitter
Uncertain significance 12
- p.Ala59Thr Single submitter ⚠
- p.Arg24His Single submitter ⚠
- p.Arg32His Single submitter ⚠
- p.Cys153Tyr Single submitter ⚠
- p.Gln128Leu Single submitter ⚠
- p.Gly54Asp Single submitter ⚠
- p.Gly72Glu Single submitter ⚠
- p.His159Tyr Single submitter ⚠
- p.Phe99Ser Single submitter ⚠
- p.Phe99Val Single submitter ⚠
- p.Pro81Thr Single submitter ⚠
- p.Thr122Ser Single submitter ⚠