TSSK1B — 71 ClinVar variants
All ClinVar germline TSSK1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
2 Likely benign · 69 Uncertain significance
Full TSSK1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 53
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TSSK1B p.Ala182Val Uncertain significance Single submitter
- TSSK1B p.Ala309Thr Uncertain significance Single submitter
- TSSK1B p.Ala309Val Uncertain significance Single submitter
- TSSK1B p.Ala4Thr Uncertain significance Single submitter
- TSSK1B p.Arg168Gln Uncertain significance Single submitter
- TSSK1B p.Arg259Leu Uncertain significance Single submitter
- TSSK1B p.Arg277Gln Uncertain significance Single submitter
- TSSK1B p.Arg292Gln Uncertain significance Single submitter
- TSSK1B p.Arg292Trp Uncertain significance Single submitter
- TSSK1B p.Arg33His Uncertain significance Single submitter
- TSSK1B p.Arg365Gln Uncertain significance Single submitter
- TSSK1B p.Arg9Gln Uncertain significance Single submitter
- TSSK1B p.Asp198Asn Uncertain significance Single submitter
- TSSK1B p.Asp217Asn Uncertain significance Single submitter
- TSSK1B p.Asp247Asn Uncertain significance Single submitter
- TSSK1B p.Cys70Tyr Uncertain significance Single submitter
- TSSK1B p.Gln193Arg Uncertain significance Single submitter
- TSSK1B p.Gln254Leu Uncertain significance Single submitter
- TSSK1B p.Gln334Lys Uncertain significance Single submitter
- TSSK1B p.Gln338Glu Uncertain significance Single submitter
- TSSK1B p.Gln95Glu Uncertain significance Single submitter
- TSSK1B p.Glu100Lys Uncertain significance Single submitter
- TSSK1B p.Glu265Lys Uncertain significance Single submitter
- TSSK1B p.Glu329Asp Uncertain significance Single submitter
- TSSK1B p.Glu329Lys Uncertain significance Single submitter
- TSSK1B p.Gly288Arg Uncertain significance Single submitter
- TSSK1B p.Gly330Val Uncertain significance Single submitter
- TSSK1B p.His251Asn Uncertain significance Single submitter
- TSSK1B p.Ile150Val Uncertain significance Single submitter
- TSSK1B p.Ile208Leu Uncertain significance Single submitter
- TSSK1B p.Ile227Val Uncertain significance Single submitter
- TSSK1B p.Ile40Leu Uncertain significance Single submitter
- TSSK1B p.Leu297Phe Uncertain significance Single submitter
- TSSK1B p.Leu67Val Uncertain significance Single submitter
- TSSK1B p.Lys146Asn Uncertain significance Single submitter
- TSSK1B p.Lys311Glu Uncertain significance Single submitter
- TSSK1B p.Met351Val Uncertain significance Single submitter
- TSSK1B p.Met66Val Uncertain significance Single submitter
- TSSK1B p.Pro357Arg Uncertain significance Single submitter
- TSSK1B p.Pro357Ser Uncertain significance Single submitter
- TSSK1B p.Pro358Ser Uncertain significance Single submitter
- TSSK1B p.Ser201Arg Uncertain significance Single submitter
- TSSK1B p.Ser291Cys Uncertain significance Single submitter
- TSSK1B p.Ser339Leu Uncertain significance Single submitter
- TSSK1B p.Ser346Arg Uncertain significance Single submitter
- TSSK1B p.Thr299Asn Uncertain significance Single submitter
- TSSK1B p.Thr310Ala Uncertain significance Single submitter
- TSSK1B p.Thr364Met Uncertain significance Single submitter
- TSSK1B p.Trp200Cys Uncertain significance Single submitter
- TSSK1B p.Val133Ile Uncertain significance Single submitter
- TSSK1B p.Val196Met Uncertain significance Single submitter
- TSSK1B p.Val233Ile Uncertain significance Single submitter
- TSSK1B p.Val257Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- TSSK1B p.Ala93Thr Uncertain significance Single submitter
- TSSK1B p.Arg105Trp Uncertain significance Single submitter
- TSSK1B p.Arg114Leu Uncertain significance Single submitter
- TSSK1B p.Arg163Gln Uncertain significance Single submitter
- TSSK1B p.Arg33Cys Uncertain significance Single submitter
- TSSK1B p.Arg59Trp Uncertain significance Single submitter
- TSSK1B p.Asp164Tyr Uncertain significance Single submitter
- TSSK1B p.Asp2Tyr Uncertain significance Single submitter
- TSSK1B p.Gly167Asp Uncertain significance Single submitter
- TSSK1B p.Leu7Phe Uncertain significance Single submitter
- TSSK1B p.Met209Val Uncertain significance Single submitter
- TSSK1B p.Pro194Arg Uncertain significance Single submitter
- TSSK1B p.Pro58Ser Uncertain significance Single submitter
- TSSK1B p.Ser156Arg Uncertain significance Single submitter
- TSSK1B p.Thr242Ile Uncertain significance Single submitter
All TSSK1B variants
Likely benign 2
- p.Ala180= Single submitter
- p.Arg277Trp Single submitter
Uncertain significance 69
- p.Ala182Val Single submitter ⚠
- p.Ala309Thr Single submitter ⚠
- p.Ala309Val Single submitter ⚠
- p.Ala4Thr Single submitter ⚠
- p.Ala93Thr Single submitter ⚠
- p.Arg105Trp Single submitter ⚠
- p.Arg114Leu Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg168Gln Single submitter ⚠
- p.Arg259Leu Single submitter ⚠
- p.Arg277Gln Single submitter ⚠
- p.Arg292Gln Single submitter ⚠
- p.Arg292Trp Single submitter ⚠
- p.Arg33Cys Single submitter ⚠
- p.Arg33His Single submitter ⚠
- p.Arg365Gln Single submitter ⚠
- p.Arg59Trp Single submitter ⚠
- p.Arg9Gln Single submitter ⚠
- p.Asp164Tyr Single submitter ⚠
- p.Asp198Asn Single submitter ⚠
- p.Asp217Asn Single submitter ⚠
- p.Asp247Asn Single submitter ⚠
- p.Asp2Tyr Single submitter ⚠
- p.Cys70Tyr Single submitter ⚠
- p.Gln193Arg Single submitter ⚠
- p.Gln254Leu Single submitter ⚠
- p.Gln334Lys Single submitter ⚠
- p.Gln338Glu Single submitter ⚠
- p.Gln95Glu Single submitter ⚠
- p.Glu100Lys Single submitter ⚠
- p.Glu265Lys Single submitter ⚠
- p.Glu329Asp Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu91Gln Single submitter
- p.Gly167Asp Single submitter ⚠
- p.Gly288Arg Single submitter ⚠
- p.Gly330Val Single submitter ⚠
- p.His251Asn Single submitter ⚠
- p.Ile150Val Single submitter ⚠
- p.Ile208Leu Single submitter ⚠
- p.Ile227Val Single submitter ⚠
- p.Ile40Leu Single submitter ⚠
- p.Leu297Phe Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Leu7Phe Single submitter ⚠
- p.Lys146Asn Single submitter ⚠
- p.Lys311Glu Single submitter ⚠
- p.Met209Val Single submitter ⚠
- p.Met351Val Single submitter ⚠
- p.Met66Val Single submitter ⚠
- p.Pro194Arg Single submitter ⚠
- p.Pro357Arg Single submitter ⚠
- p.Pro357Ser Single submitter ⚠
- p.Pro358Ser Single submitter ⚠
- p.Pro58Ser Single submitter ⚠
- p.Ser156Arg Single submitter ⚠
- p.Ser201Arg Single submitter ⚠
- p.Ser291Cys Single submitter ⚠
- p.Ser339Leu Single submitter ⚠
- p.Ser346Arg Single submitter ⚠
- p.Thr242Ile Single submitter ⚠
- p.Thr299Asn Single submitter ⚠
- p.Thr310Ala Single submitter ⚠
- p.Thr364Met Single submitter ⚠
- p.Trp200Cys Single submitter ⚠
- p.Val133Ile Single submitter ⚠
- p.Val196Met Single submitter ⚠
- p.Val233Ile Single submitter ⚠
- p.Val257Ile Single submitter ⚠