TTC14 — 105 ClinVar variants
All ClinVar germline TTC14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 90 flagged for review →
3 Benign · 9 Likely benign · 93 Uncertain significance
Full TTC14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 90
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 80
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TTC14 p.Ala157Thr Uncertain significance Single submitter
- TTC14 p.Ala163Val Uncertain significance Single submitter
- TTC14 p.Ala304Ser Uncertain significance Single submitter
- TTC14 p.Ala408Gly Uncertain significance Single submitter
- TTC14 p.Ala731Thr Uncertain significance Single submitter
- TTC14 p.Arg121Gln Uncertain significance Single submitter
- TTC14 p.Arg190Gln Uncertain significance Single submitter
- TTC14 p.Arg473Lys Uncertain significance Single submitter
- TTC14 p.Arg501Ser Uncertain significance Single submitter
- TTC14 p.Arg509His Uncertain significance Single submitter
- TTC14 p.Arg514Cys Uncertain significance Single submitter
- TTC14 p.Arg522Met Uncertain significance Single submitter
- TTC14 p.Arg621Lys Uncertain significance Single submitter
- TTC14 p.Asn28Ser Uncertain significance Single submitter
- TTC14 p.Asn508Ser Uncertain significance Single submitter
- TTC14 p.Asn531Lys Uncertain significance Single submitter
- TTC14 p.Asn542Asp Uncertain significance Single submitter
- TTC14 p.Asn602Lys Uncertain significance Single submitter
- TTC14 p.Asn61Asp Uncertain significance Single submitter
- TTC14 p.Asn717Ser Uncertain significance Single submitter
- TTC14 p.Asp293Tyr Uncertain significance Single submitter
- TTC14 p.Asp417Val Uncertain significance Single submitter
- TTC14 p.Asp562Asn Uncertain significance Single submitter
- TTC14 p.Asp596Glu Uncertain significance Single submitter
- TTC14 p.Cys12Trp Uncertain significance Single submitter
- TTC14 p.Gln709Lys Uncertain significance Single submitter
- TTC14 p.Glu238Ala Uncertain significance Single submitter
- TTC14 p.Glu264Gln Uncertain significance Single submitter
- TTC14 p.Glu662Asp Uncertain significance Single submitter
- TTC14 p.Glu713Lys Uncertain significance Single submitter
- TTC14 p.Glu739Gln Uncertain significance Single submitter
- TTC14 p.Glu763Gly Uncertain significance Single submitter
- TTC14 p.Gly559Arg Uncertain significance Single submitter
- TTC14 p.His505Arg Uncertain significance Single submitter
- TTC14 p.His505Asp Uncertain significance Single submitter
- TTC14 p.His550Arg Uncertain significance Single submitter
- TTC14 p.Ile128Thr Uncertain significance Single submitter
- TTC14 p.Ile136Val Uncertain significance Single submitter
- TTC14 p.Ile161Val Uncertain significance Single submitter
- TTC14 p.Ile272Val Uncertain significance Single submitter
- TTC14 p.Ile313Met Uncertain significance Single submitter
- TTC14 p.Ile528Met Uncertain significance Single submitter
- TTC14 p.Ile90Leu Uncertain significance Single submitter
- TTC14 p.Leu579Val Uncertain significance Single submitter
- TTC14 p.Lys338Arg Uncertain significance Single submitter
- TTC14 p.Lys447Thr Uncertain significance Single submitter
- TTC14 p.Lys574Arg Uncertain significance Single submitter
- TTC14 p.Lys574Glu Uncertain significance Single submitter
- TTC14 p.Lys735Arg Uncertain significance Single submitter
- TTC14 p.Met113Val Uncertain significance Single submitter
- TTC14 p.Met153Lys Uncertain significance Single submitter
- TTC14 p.Met153Val Uncertain significance Single submitter
- TTC14 p.Met251Ile Uncertain significance Single submitter
- TTC14 p.Met327Lys Uncertain significance Single submitter
- TTC14 p.Pro50Leu Uncertain significance Single submitter
- TTC14 p.Pro587Ser Uncertain significance Single submitter
- TTC14 p.Pro616Ala Uncertain significance Single submitter
- TTC14 p.Pro672Ser Uncertain significance Single submitter
- TTC14 p.Pro85Leu Uncertain significance Single submitter
- TTC14 p.Ser236Asn Uncertain significance Single submitter
- TTC14 p.Ser236Thr Uncertain significance Single submitter
- TTC14 p.Ser243Tyr Uncertain significance Single submitter
- TTC14 p.Ser477Thr Uncertain significance Single submitter
- TTC14 p.Ser524Tyr Uncertain significance Single submitter
- TTC14 p.Ser603Thr Uncertain significance Single submitter
- TTC14 p.Ser610Gly Uncertain significance Single submitter
- TTC14 p.Ser630Ala Uncertain significance Single submitter
- TTC14 p.Ser669Pro Uncertain significance Single submitter
- TTC14 p.Ser79Pro Uncertain significance Single submitter
- TTC14 p.Ser94Gly Uncertain significance Single submitter
- TTC14 p.Thr707Ile Uncertain significance Single submitter
- TTC14 p.Tyr601Cys Uncertain significance Single submitter
- TTC14 p.Tyr604Asn Uncertain significance Single submitter
- TTC14 p.Tyr604Ser Uncertain significance Single submitter
- TTC14 p.Tyr617Cys Uncertain significance Single submitter
- TTC14 p.Tyr685His Uncertain significance Single submitter
- TTC14 p.Tyr688Cys Uncertain significance Single submitter
- TTC14 p.Tyr98Cys Uncertain significance Single submitter
- TTC14 p.Val341Met Uncertain significance Single submitter
- TTC14 p.Val726Ala Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TTC14 p.Ala455Thr Uncertain significance Single submitter
- TTC14 p.Leu148Ser Uncertain significance Single submitter
- TTC14 p.Met281Thr Uncertain significance Single submitter
- TTC14 p.Pro260Ala Uncertain significance Single submitter
- TTC14 p.Ser211Phe Uncertain significance Single submitter
- TTC14 p.Ser305Pro Uncertain significance Single submitter
- TTC14 p.Ser480Asn Uncertain significance Single submitter
- TTC14 p.Ser492Leu Uncertain significance Single submitter
- TTC14 p.Ser69Phe Uncertain significance Single submitter
- TTC14 p.Ser9Leu Uncertain significance Single submitter
All TTC14 variants
Benign 3
- c.287-3dup No assertion criteria TTC14-related disorder
- p.Ala352= No assertion criteria TTC14-related disorder
- p.Ser296= No assertion criteria TTC14-related disorder
Likely benign 9
- p.Ala689Thr Single submitter
- p.Glu268Gly Single submitter
- p.Ile528Val Single submitter
- p.Ile651Thr Single submitter
- p.Asn602= No assertion criteria TTC14-related disorder
- p.His505Tyr No assertion criteria TTC14-related disorder
- p.Ile313= No assertion criteria TTC14-related disorder
- p.Leu381= No assertion criteria TTC14-related disorder
- p.Ser678= No assertion criteria TTC14-related disorder
Uncertain significance 93
- p.Ala157Thr Single submitter ⚠
- p.Ala163Val Single submitter ⚠
- p.Ala304Ser Single submitter ⚠
- p.Ala408Gly Single submitter ⚠
- p.Ala455Thr Single submitter ⚠
- p.Ala731Thr Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg190Gln Single submitter ⚠
- p.Arg473Lys Single submitter ⚠
- p.Arg501Ser Single submitter ⚠
- p.Arg509His Single submitter ⚠
- p.Arg514Cys Single submitter ⚠
- p.Arg522Met Single submitter ⚠
- p.Arg621Lys Single submitter ⚠
- p.Asn28Ser Single submitter ⚠
- p.Asn508Ser Single submitter ⚠
- p.Asn531Lys Single submitter ⚠
- p.Asn542Asp Single submitter ⚠
- p.Asn602Lys Single submitter ⚠
- p.Asn61Asp Single submitter ⚠
- p.Asn717Ser Single submitter ⚠
- p.Asp293Tyr Single submitter ⚠
- p.Asp417Val Single submitter ⚠
- p.Asp562Asn Single submitter ⚠
- p.Asp596Glu Single submitter ⚠
- p.Cys12Trp Single submitter ⚠
- p.Gln709Lys Single submitter ⚠
- p.Glu227Gly Single submitter
- p.Glu238Ala Single submitter ⚠
- p.Glu264Gln Single submitter ⚠
- p.Glu662Asp Single submitter ⚠
- p.Glu713Lys Single submitter ⚠
- p.Glu739Gln Single submitter ⚠
- p.Glu763Gly Single submitter ⚠
- p.Gly559Arg Single submitter ⚠
- p.His505Arg Single submitter ⚠
- p.His505Asp Single submitter ⚠
- p.His550Arg Single submitter ⚠
- p.Ile128Thr Single submitter ⚠
- p.Ile136Val Single submitter ⚠
- p.Ile161Val Single submitter ⚠
- p.Ile272Val Single submitter ⚠
- p.Ile313Met Single submitter ⚠
- p.Ile528Met Single submitter ⚠
- p.Ile90Leu Single submitter ⚠
- p.Leu148Ser Single submitter ⚠
- p.Leu579Val Single submitter ⚠
- p.Lys338Arg Single submitter ⚠
- p.Lys447Thr Single submitter ⚠
- p.Lys574Arg Single submitter ⚠
- p.Lys574Glu Single submitter ⚠
- p.Lys735Arg Single submitter ⚠
- p.Met113Val Single submitter ⚠
- p.Met153Lys Single submitter ⚠
- p.Met153Val Single submitter ⚠
- p.Met251Ile Single submitter ⚠
- p.Met281Thr Single submitter ⚠
- p.Met327Lys Single submitter ⚠
- p.Phe294Cys Single submitter
- p.Pro260Ala Single submitter ⚠
- p.Pro50Leu Single submitter ⚠
- p.Pro587Ser Single submitter ⚠
- p.Pro616Ala Single submitter ⚠
- p.Pro672Ser Single submitter ⚠
- p.Pro85Leu Single submitter ⚠
- p.Ser211Phe Single submitter ⚠
- p.Ser236Asn Single submitter ⚠
- p.Ser236Thr Single submitter ⚠
- p.Ser243Tyr Single submitter ⚠
- p.Ser305Pro Single submitter ⚠
- p.Ser477Thr Single submitter ⚠
- p.Ser480Asn Single submitter ⚠
- p.Ser492Leu Single submitter ⚠
- p.Ser524Tyr Single submitter ⚠
- p.Ser603Thr Single submitter ⚠
- p.Ser610Gly Single submitter ⚠
- p.Ser630Ala Single submitter ⚠
- p.Ser669Pro Single submitter ⚠
- p.Ser69Phe Single submitter ⚠
- p.Ser79Pro Single submitter ⚠
- p.Ser94Gly Single submitter ⚠
- p.Ser9Leu Single submitter ⚠
- p.Thr707Ile Single submitter ⚠
- p.Tyr601Cys Single submitter ⚠
- p.Tyr604Asn Single submitter ⚠
- p.Tyr604Ser Single submitter ⚠
- p.Tyr617Cys Single submitter ⚠
- p.Tyr685His Single submitter ⚠
- p.Tyr688Cys Single submitter ⚠
- p.Tyr98Cys Single submitter ⚠
- p.Val341Met Single submitter ⚠
- p.Val386Ile Single submitter
- p.Val726Ala Single submitter ⚠