TTK — 110 ClinVar variants
All ClinVar germline TTK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 99 flagged for review →
3 Benign · 9 Likely benign · 98 Uncertain significance
Full TTK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 99
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TTK p.Ala110Pro Uncertain significance Single submitter
- TTK p.Ala251Gly Uncertain significance Single submitter
- TTK p.Ala401Pro Uncertain significance Single submitter
- TTK p.Ala402Val Uncertain significance Single submitter
- TTK p.Ala787Gly Uncertain significance Single submitter
- TTK p.Arg256Pro Uncertain significance Single submitter
- TTK p.Arg414Gly Uncertain significance Single submitter
- TTK p.Arg90His Uncertain significance Single submitter
- TTK p.Asn319Ser Uncertain significance Single submitter
- TTK p.Asp101Glu Uncertain significance Single submitter
- TTK p.Asp126Gly Uncertain significance Single submitter
- TTK p.Asp285Val Uncertain significance Single submitter
- TTK p.Asp681Glu Uncertain significance Single submitter
- TTK p.Cys490Gly Uncertain significance Single submitter
- TTK p.Gln212Pro Uncertain significance Single submitter
- TTK p.Gln249Pro Uncertain significance Single submitter
- TTK p.Gln408His Uncertain significance Single submitter
- TTK p.Gln480Pro Uncertain significance Single submitter
- TTK p.Gln579Arg Uncertain significance Single submitter
- TTK p.Gln596His Uncertain significance Single submitter
- TTK p.Glu10Gln Uncertain significance Single submitter
- TTK p.Glu252Gly Uncertain significance Single submitter
- TTK p.Glu761Gly Uncertain significance Single submitter
- TTK p.Gly535Cys Uncertain significance Single submitter
- TTK p.Gly642Asp Uncertain significance Single submitter
- TTK p.Gly705Glu Uncertain significance Single submitter
- TTK p.Gly814Ala Uncertain significance Single submitter
- TTK p.Gly814Ser Uncertain significance Single submitter
- TTK p.Gly818Asp Uncertain significance Single submitter
- TTK p.Gly839Ser Uncertain significance Single submitter
- TTK p.His146Arg Uncertain significance Single submitter
- TTK p.His581Tyr Uncertain significance Single submitter
- TTK p.His842Arg Uncertain significance Single submitter
- TTK p.Ile253Thr Uncertain significance Single submitter
- TTK p.Ile586Val Uncertain significance Single submitter
- TTK p.Ile638Thr Uncertain significance Single submitter
- TTK p.Ile95Val Uncertain significance Single submitter
- TTK p.Leu219His Uncertain significance Single submitter
- TTK p.Leu588His Uncertain significance Single submitter
- TTK p.Lys102Glu Uncertain significance Single submitter
- TTK p.Lys201Arg Uncertain significance Single submitter
- TTK p.Lys40Arg Uncertain significance Single submitter
- TTK p.Lys415Glu Uncertain significance Single submitter
- TTK p.Lys731Arg Uncertain significance Single submitter
- TTK p.Lys856Arg Uncertain significance Single submitter
- TTK p.Met297Leu Uncertain significance Single submitter
- TTK p.Met463Val Uncertain significance Single submitter
- TTK p.Met57Val Uncertain significance Single submitter
- TTK p.Phe109Ile Uncertain significance Single submitter
- TTK p.Phe109Leu Uncertain significance Single submitter
- TTK p.Phe109Ser Uncertain significance Single submitter
- TTK p.Pro176Ala Uncertain significance Single submitter
- TTK p.Pro78Leu Uncertain significance Single submitter
- TTK p.Ser108Arg Uncertain significance Single submitter
- TTK p.Ser228Asn Uncertain significance Single submitter
- TTK p.Ser455Asn Uncertain significance Single submitter
- TTK p.Ser611Asn Uncertain significance Single submitter
- TTK p.Ser712Ile Uncertain significance Single submitter
- TTK p.Ser7Asn Uncertain significance Single submitter
- TTK p.Thr236Ala Uncertain significance Single submitter
- TTK p.Thr288Ile Uncertain significance Single submitter
- TTK p.Thr288Ser Uncertain significance Single submitter
- TTK p.Thr351Ala Uncertain significance Single submitter
- TTK p.Thr360Arg Uncertain significance Single submitter
- TTK p.Thr46Ala Uncertain significance Single submitter
- TTK p.Tyr242Cys Uncertain significance Single submitter
- TTK p.Tyr485His Uncertain significance Single submitter
- TTK p.Tyr554His Uncertain significance Single submitter
- TTK p.Tyr833Cys Uncertain significance Single submitter
- TTK p.Tyr836Cys Uncertain significance Single submitter
- TTK p.Val293Ile Uncertain significance Single submitter
- TTK p.Val330Leu Uncertain significance Single submitter
- TTK p.Val416Leu Uncertain significance Single submitter
- TTK p.Val77Phe Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- TTK p.Arg129Cys Uncertain significance Single submitter
- TTK p.Arg569Gln Uncertain significance Single submitter
- TTK p.Asn158Asp Uncertain significance Single submitter
- TTK p.Asn556Ser Uncertain significance Single submitter
- TTK p.Asn576His Uncertain significance Single submitter
- TTK p.Gln113Glu Uncertain significance Single submitter
- TTK p.Gln167His Likely benign Single submitter
- TTK p.Glu107Lys Uncertain significance Single submitter
- TTK p.Gly730Arg Uncertain significance Single submitter
- TTK p.Ile527Leu Uncertain significance Single submitter
- TTK p.Ile531Leu Uncertain significance Single submitter
- TTK p.Ile619Thr Uncertain significance Single submitter
- TTK p.Leu166Ile Uncertain significance Single submitter
- TTK p.Leu609Phe Uncertain significance Single submitter
- TTK p.Leu70Phe Uncertain significance Single submitter
- TTK p.Pro410Leu Uncertain significance Single submitter
- TTK p.Pro469Leu Uncertain significance Single submitter
- TTK p.Pro757Ser Uncertain significance Single submitter
- TTK p.Ser148Cys Uncertain significance Single submitter
- TTK p.Ser321Ala Uncertain significance Single submitter
- TTK p.Ser442Cys Uncertain significance Single submitter
- TTK p.Ser715Asn Uncertain significance Single submitter
- TTK p.Ser841Arg Uncertain significance Single submitter
- TTK p.Thr453Ile Uncertain significance Single submitter
- TTK p.Tyr726Cys Uncertain significance Single submitter
All TTK variants
Benign 3
- c.2392+9T>A Single submitter
- p.Asn823His Single submitter
- p.Pro410= Single submitter
Likely benign 9
- p.Thr423= Multiple submitters
- p.Ala205= Single submitter
- p.Gln167His Single submitter ⚠
- p.Glu851Gly Single submitter
- p.Gly217Ser Single submitter
- p.Ile439Met Single submitter
- p.Ile450Val Single submitter
- p.Tyr255His Single submitter
- p.Val508Ile Single submitter
Uncertain significance 98
- p.Ala110Pro Single submitter ⚠
- p.Ala251Gly Single submitter ⚠
- p.Ala401Pro Single submitter ⚠
- p.Ala402Val Single submitter ⚠
- p.Ala787Gly Single submitter ⚠
- p.Arg129Cys Single submitter ⚠
- p.Arg256Pro Single submitter ⚠
- p.Arg414Gly Single submitter ⚠
- p.Arg569Gln Single submitter ⚠
- p.Arg90His Single submitter ⚠
- p.Asn158Asp Single submitter ⚠
- p.Asn319Ser Single submitter ⚠
- p.Asn556Ser Single submitter ⚠
- p.Asn576His Single submitter ⚠
- p.Asp101Glu Single submitter ⚠
- p.Asp126Gly Single submitter ⚠
- p.Asp285Val Single submitter ⚠
- p.Asp681Glu Single submitter ⚠
- p.Cys490Gly Single submitter ⚠
- p.Gln113Glu Single submitter ⚠
- p.Gln212Pro Single submitter ⚠
- p.Gln249Pro Single submitter ⚠
- p.Gln408His Single submitter ⚠
- p.Gln480Pro Single submitter ⚠
- p.Gln579Arg Single submitter ⚠
- p.Gln596His Single submitter ⚠
- p.Glu107Lys Single submitter ⚠
- p.Glu10Gln Single submitter ⚠
- p.Glu252Gly Single submitter ⚠
- p.Glu761Gly Single submitter ⚠
- p.Gly535Cys Single submitter ⚠
- p.Gly642Asp Single submitter ⚠
- p.Gly705Glu Single submitter ⚠
- p.Gly730Arg Single submitter ⚠
- p.Gly814Ala Single submitter ⚠
- p.Gly814Ser Single submitter ⚠
- p.Gly818Asp Single submitter ⚠
- p.Gly839Ser Single submitter ⚠
- p.His146Arg Single submitter ⚠
- p.His581Tyr Single submitter ⚠
- p.His842Arg Single submitter ⚠
- p.Ile253Thr Single submitter ⚠
- p.Ile527Leu Single submitter ⚠
- p.Ile531Leu Single submitter ⚠
- p.Ile586Val Single submitter ⚠
- p.Ile619Thr Single submitter ⚠
- p.Ile638Thr Single submitter ⚠
- p.Ile95Val Single submitter ⚠
- p.Leu166Ile Single submitter ⚠
- p.Leu219His Single submitter ⚠
- p.Leu588His Single submitter ⚠
- p.Leu609Phe Single submitter ⚠
- p.Leu70Phe Single submitter ⚠
- p.Lys102Glu Single submitter ⚠
- p.Lys201Arg Single submitter ⚠
- p.Lys40Arg Single submitter ⚠
- p.Lys415Glu Single submitter ⚠
- p.Lys731Arg Single submitter ⚠
- p.Lys856Arg Single submitter ⚠
- p.Met297Leu Single submitter ⚠
- p.Met463Val Single submitter ⚠
- p.Met57Val Single submitter ⚠
- p.Phe109Ile Single submitter ⚠
- p.Phe109Leu Single submitter ⚠
- p.Phe109Ser Single submitter ⚠
- p.Pro176Ala Single submitter ⚠
- p.Pro410Leu Single submitter ⚠
- p.Pro469Leu Single submitter ⚠
- p.Pro757Ser Single submitter ⚠
- p.Pro78Leu Single submitter ⚠
- p.Ser108Arg Single submitter ⚠
- p.Ser148Cys Single submitter ⚠
- p.Ser228Asn Single submitter ⚠
- p.Ser321Ala Single submitter ⚠
- p.Ser442Cys Single submitter ⚠
- p.Ser455Asn Single submitter ⚠
- p.Ser611Asn Single submitter ⚠
- p.Ser712Ile Single submitter ⚠
- p.Ser715Asn Single submitter ⚠
- p.Ser7Asn Single submitter ⚠
- p.Ser841Arg Single submitter ⚠
- p.Thr236Ala Single submitter ⚠
- p.Thr288Ile Single submitter ⚠
- p.Thr288Ser Single submitter ⚠
- p.Thr351Ala Single submitter ⚠
- p.Thr360Arg Single submitter ⚠
- p.Thr453Ile Single submitter ⚠
- p.Thr46Ala Single submitter ⚠
- p.Tyr242Cys Single submitter ⚠
- p.Tyr485His Single submitter ⚠
- p.Tyr554His Single submitter ⚠
- p.Tyr726Cys Single submitter ⚠
- p.Tyr833Cys Single submitter ⚠
- p.Tyr836Cys Single submitter ⚠
- p.Val293Ile Single submitter ⚠
- p.Val330Leu Single submitter ⚠
- p.Val416Leu Single submitter ⚠
- p.Val77Phe Single submitter ⚠