Sugi Variant

Sugi Variant/TTLL5

TTLL5 — 1184 ClinVar variants

All ClinVar germline TTLL5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 572 flagged for review →

56 Pathogenic · 17 Pathogenic/Likely pathogenic · 30 Likely pathogenic · 33 Conflicting · 32 Benign · 23 Benign/Likely benign · 388 Likely benign · 605 Uncertain significance

Full TTLL5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 572

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 20

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 446

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 446

Predictors split 106

The independent predictors disagree with each other — read with care.

All TTLL5 variants

Pathogenic 56

Pathogenic/Likely pathogenic 17

Likely pathogenic 30

Conflicting classifications of pathogenicity 33

Benign 32

Benign/Likely benign 23

Likely benign 388

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 605

Showing the top 300 by review status; the full set is in the sitemap.