TUBA3C — 59 ClinVar variants
All ClinVar germline TUBA3C variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
2 Likely benign · 57 Uncertain significance
Full TUBA3C gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TUBA3C p.Ala150Thr Uncertain significance Single submitter
- TUBA3C p.Ala403Thr Uncertain significance Single submitter
- TUBA3C p.Ala442Gly Uncertain significance Single submitter
- TUBA3C p.Arg121Trp Uncertain significance Single submitter
- TUBA3C p.Arg123Gly Uncertain significance Single submitter
- TUBA3C p.Arg215Cys Uncertain significance Single submitter
- TUBA3C p.Arg2His Uncertain significance Single submitter
- TUBA3C p.Arg308His Uncertain significance Single submitter
- TUBA3C p.Arg339His Uncertain significance Single submitter
- TUBA3C p.Arg339Pro Uncertain significance Single submitter
- TUBA3C p.Arg373Gln Uncertain significance Single submitter
- TUBA3C p.Arg373Trp Uncertain significance Single submitter
- TUBA3C p.Arg422Leu Uncertain significance Single submitter
- TUBA3C p.Asn50Ser Uncertain significance Single submitter
- TUBA3C p.Asp431Ala Uncertain significance Single submitter
- TUBA3C p.Cys20Tyr Uncertain significance Single submitter
- TUBA3C p.Cys315Ser Uncertain significance Single submitter
- TUBA3C p.Gln372Arg Uncertain significance Single submitter
- TUBA3C p.Glu279Lys Uncertain significance Single submitter
- TUBA3C p.Gly106Cys Uncertain significance Single submitter
- TUBA3C p.Gly17Asp Uncertain significance Single submitter
- TUBA3C p.Gly17Ser Uncertain significance Single submitter
- TUBA3C p.Gly59Arg Uncertain significance Single submitter
- TUBA3C p.Ile332Thr Uncertain significance Single submitter
- TUBA3C p.Ile42Thr Uncertain significance Single submitter
- TUBA3C p.Leu397Phe Uncertain significance Single submitter
- TUBA3C p.Lys394Gln Uncertain significance Single submitter
- TUBA3C p.Thr239Met Uncertain significance Single submitter
- TUBA3C p.Thr361Lys Uncertain significance Single submitter
- TUBA3C p.Thr382Met Uncertain significance Single submitter
- TUBA3C p.Thr51Met Uncertain significance Single submitter
- TUBA3C p.Tyr185Cys Uncertain significance Single submitter
- TUBA3C p.Tyr408Cys Uncertain significance Single submitter
- TUBA3C p.Val177Ile Uncertain significance Single submitter
- TUBA3C p.Val288Met Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- TUBA3C p.Ala126Val Uncertain significance Single submitter
- TUBA3C p.Ala330Val Uncertain significance Single submitter
- TUBA3C p.Arg214Gln Uncertain significance Single submitter
- TUBA3C p.Arg243Gln Uncertain significance Single submitter
- TUBA3C p.Glu443Gln Uncertain significance Single submitter
- TUBA3C p.Glu446Val Uncertain significance Single submitter
- TUBA3C p.Ile276Val Uncertain significance Single submitter
- TUBA3C p.Ile335Val Uncertain significance Single submitter
- TUBA3C p.Leu86Ile Uncertain significance Single submitter
- TUBA3C p.Lys124Arg Uncertain significance Single submitter
- TUBA3C p.Ser38Asn Uncertain significance Single submitter
- TUBA3C p.Thr130Ala Uncertain significance Single submitter
- TUBA3C p.Thr130Met Uncertain significance Single submitter
- TUBA3C p.Thr73Ala Uncertain significance Single submitter
All TUBA3C variants
Uncertain significance 57
- p.Ala126Val Single submitter ⚠
- p.Ala150Thr Single submitter ⚠
- p.Ala330Val Single submitter ⚠
- p.Ala403Thr Single submitter ⚠
- p.Ala442Gly Single submitter ⚠
- p.Arg121Gln Single submitter
- p.Arg121Trp Single submitter ⚠
- p.Arg123Gly Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg215Cys Single submitter ⚠
- p.Arg221His Single submitter
- p.Arg243Gln Single submitter ⚠
- p.Arg2His Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg339His Single submitter ⚠
- p.Arg339Pro Single submitter ⚠
- p.Arg373Gln Single submitter ⚠
- p.Arg373Trp Single submitter ⚠
- p.Arg422Leu Single submitter ⚠
- p.Asn50Ser Single submitter ⚠
- p.Asp431Ala Single submitter ⚠
- p.Cys20Tyr Single submitter ⚠
- p.Cys315Ser Single submitter ⚠
- p.Gln372Arg Single submitter ⚠
- p.Glu220Gly Single submitter
- p.Glu279Lys Single submitter ⚠
- p.Glu443Gln Single submitter ⚠
- p.Glu446Val Single submitter ⚠
- p.Gly106Cys Single submitter ⚠
- p.Gly17Asp Single submitter ⚠
- p.Gly17Ser Single submitter ⚠
- p.Gly59Arg Single submitter ⚠
- p.His309Gln Single submitter
- p.Ile276Val Single submitter ⚠
- p.Ile30Val Single submitter
- p.Ile332Thr Single submitter ⚠
- p.Ile335Val Single submitter ⚠
- p.Ile42Thr Single submitter ⚠
- p.Leu132Val Single submitter
- p.Leu397Phe Single submitter ⚠
- p.Leu86Ile Single submitter ⚠
- p.Lys124Arg Single submitter ⚠
- p.Lys394Gln Single submitter ⚠
- p.Ser38Asn Single submitter ⚠
- p.Thr130Ala Single submitter ⚠
- p.Thr130Met Single submitter ⚠
- p.Thr239Met Single submitter ⚠
- p.Thr361Lys Single submitter ⚠
- p.Thr361Met Single submitter
- p.Thr382Met Single submitter ⚠
- p.Thr51Met Single submitter ⚠
- p.Thr73Ala Single submitter ⚠
- p.Tyr185Cys Single submitter ⚠
- p.Tyr408Cys Single submitter ⚠
- p.Val177Ile Single submitter ⚠
- p.Val288Met Single submitter ⚠
- p.Val9Met Single submitter