TUBAL3 — 88 ClinVar variants
All ClinVar germline TUBAL3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 70 flagged for review →
3 Benign · 9 Likely benign · 76 Uncertain significance
Full TUBAL3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 70
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TUBAL3 p.Ala111Thr Uncertain significance Single submitter
- TUBAL3 p.Ala280Thr Uncertain significance Single submitter
- TUBAL3 p.Ala340Thr Uncertain significance Single submitter
- TUBAL3 p.Ala340Val Uncertain significance Single submitter
- TUBAL3 p.Ala407Ser Uncertain significance Single submitter
- TUBAL3 p.Ala407Thr Uncertain significance Single submitter
- TUBAL3 p.Ala428Thr Uncertain significance Single submitter
- TUBAL3 p.Ala428Val Uncertain significance Single submitter
- TUBAL3 p.Arg146Gln Uncertain significance Single submitter
- TUBAL3 p.Arg170Ser Uncertain significance Single submitter
- TUBAL3 p.Arg271Ile Uncertain significance Single submitter
- TUBAL3 p.Arg315Gln Uncertain significance Single submitter
- TUBAL3 p.Arg91Cys Uncertain significance Single submitter
- TUBAL3 p.Cys302Trp Uncertain significance Single submitter
- TUBAL3 p.Gln11Pro Uncertain significance Single submitter
- TUBAL3 p.Gln292His Uncertain significance Single submitter
- TUBAL3 p.Glu167Gly Uncertain significance Single submitter
- TUBAL3 p.Glu190Gly Uncertain significance Single submitter
- TUBAL3 p.Glu203Lys Uncertain significance Single submitter
- TUBAL3 p.Glu227Ala Uncertain significance Single submitter
- TUBAL3 p.Glu440Lys Uncertain significance Single submitter
- TUBAL3 p.Glu440Val Uncertain significance Single submitter
- TUBAL3 p.Glu441Gln Uncertain significance Single submitter
- TUBAL3 p.Glu50Lys Uncertain significance Single submitter
- TUBAL3 p.Gly10Ser Uncertain significance Single submitter
- TUBAL3 p.Gly225Ser Uncertain significance Single submitter
- TUBAL3 p.Gly419Val Uncertain significance Single submitter
- TUBAL3 p.His28Tyr Uncertain significance Single submitter
- TUBAL3 p.His346Tyr Uncertain significance Single submitter
- TUBAL3 p.His413Arg Uncertain significance Single submitter
- TUBAL3 p.His90Gln Uncertain significance Single submitter
- TUBAL3 p.Ile16Asn Uncertain significance Single submitter
- TUBAL3 p.Ile282Val Uncertain significance Single submitter
- TUBAL3 p.Ile30Val Uncertain significance Single submitter
- TUBAL3 p.Ile9Val Uncertain significance Single submitter
- TUBAL3 p.Lys359Thr Uncertain significance Single submitter
- TUBAL3 p.Met420Ile Uncertain significance Single submitter
- TUBAL3 p.Phe251Leu Uncertain significance Single submitter
- TUBAL3 p.Phe425Tyr Uncertain significance Single submitter
- TUBAL3 p.Phe446Tyr Uncertain significance Single submitter
- TUBAL3 p.Pro268Thr Uncertain significance Single submitter
- TUBAL3 p.Ser296Leu Uncertain significance Single submitter
- TUBAL3 p.Ser344Leu Uncertain significance Single submitter
- TUBAL3 p.Thr172Ile Uncertain significance Single submitter
- TUBAL3 p.Thr172Ser Uncertain significance Single submitter
- TUBAL3 p.Thr198Ser Uncertain significance Single submitter
- TUBAL3 p.Thr299Asn Uncertain significance Single submitter
- TUBAL3 p.Thr389Met Uncertain significance Single submitter
- TUBAL3 p.Thr52Ile Uncertain significance Single submitter
- TUBAL3 p.Thr58Asn Uncertain significance Single submitter
- TUBAL3 p.Tyr192Cys Uncertain significance Single submitter
- TUBAL3 p.Val216Leu Uncertain significance Single submitter
- TUBAL3 p.Val267Ala Uncertain significance Single submitter
- TUBAL3 p.Val295Glu Uncertain significance Single submitter
- TUBAL3 p.Val351Ile Uncertain significance Single submitter
- TUBAL3 p.Val35Ile Uncertain significance Single submitter
- TUBAL3 p.Val369Met Uncertain significance Single submitter
- TUBAL3 p.Val392Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- TUBAL3 p.Ala19Thr Uncertain significance Multiple submitters
- TUBAL3 p.Ala19Val Uncertain significance Single submitter
- TUBAL3 p.Arg130Trp Uncertain significance Single submitter
- TUBAL3 p.Asp83Gly Uncertain significance Single submitter
- TUBAL3 p.His413Tyr Uncertain significance Single submitter
- TUBAL3 p.His95Tyr Uncertain significance Single submitter
- TUBAL3 p.Ile82Thr Uncertain significance Single submitter
- TUBAL3 p.Lys173Met Uncertain significance Single submitter
- TUBAL3 p.Phe156Leu Uncertain significance Single submitter
- TUBAL3 p.Pro229Ser Uncertain significance Single submitter
- TUBAL3 p.Ser294Tyr Uncertain significance Single submitter
- TUBAL3 p.Val295Met Uncertain significance Single submitter
All TUBAL3 variants
Benign 3
- p.Gln135His Multiple submitters
- p.Ile339= Multiple submitters
- p.Thr157= Multiple submitters
Likely benign 9
- p.Ala111= Single submitter
- p.Arg114His Single submitter
- p.Arg91Pro Single submitter
- p.Asp57Asn Single submitter
- p.Tyr406= Single submitter
- p.Val216Ile Single submitter
- p.Val242Ile Single submitter
- p.Val360= Single submitter
- p.Val75Met Single submitter
Uncertain significance 76
- p.Ala19Thr Multiple submitters ⚠
- p.Ala107Val Single submitter
- p.Ala111Thr Single submitter ⚠
- p.Ala133Glu Single submitter
- p.Ala19Val Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala340Thr Single submitter ⚠
- p.Ala340Val Single submitter ⚠
- p.Ala407Ser Single submitter ⚠
- p.Ala407Thr Single submitter ⚠
- p.Ala428Thr Single submitter ⚠
- p.Ala428Val Single submitter ⚠
- p.Arg130Trp Single submitter ⚠
- p.Arg146Gln Single submitter ⚠
- p.Arg170Ser Single submitter ⚠
- p.Arg271Ile Single submitter ⚠
- p.Arg315Gln Single submitter ⚠
- p.Arg91Cys Single submitter ⚠
- p.Asp83Gly Single submitter ⚠
- p.Cys302Trp Single submitter ⚠
- p.Gln11Pro Single submitter ⚠
- p.Gln292His Single submitter ⚠
- p.Glu167Gly Single submitter ⚠
- p.Glu190Gly Single submitter ⚠
- p.Glu203Lys Single submitter ⚠
- p.Glu227Ala Single submitter ⚠
- p.Glu440Lys Single submitter ⚠
- p.Glu440Val Single submitter ⚠
- p.Glu441Gln Single submitter ⚠
- p.Glu50Lys Single submitter ⚠
- p.Gly10Ser Single submitter ⚠
- p.Gly225Ser Single submitter ⚠
- p.Gly419Val Single submitter ⚠
- p.His28Tyr Single submitter ⚠
- p.His346Tyr Single submitter ⚠
- p.His413Arg Single submitter ⚠
- p.His413Tyr Single submitter ⚠
- p.His90Gln Single submitter ⚠
- p.His95Gln Single submitter
- p.His95Tyr Single submitter ⚠
- p.Ile16Asn Single submitter ⚠
- p.Ile282Val Single submitter ⚠
- p.Ile30Val Single submitter ⚠
- p.Ile82Thr Single submitter ⚠
- p.Ile85Ser Single submitter
- p.Ile9Val Single submitter ⚠
- p.Lys173Met Single submitter ⚠
- p.Lys359Thr Single submitter ⚠
- p.Met276Lys Single submitter
- p.Met420Ile Single submitter ⚠
- p.Phe156Leu Single submitter ⚠
- p.Phe251Leu Single submitter ⚠
- p.Phe425Tyr Single submitter ⚠
- p.Phe446Tyr Single submitter ⚠
- p.Pro229Ser Single submitter ⚠
- p.Pro268Thr Single submitter ⚠
- p.Ser294Tyr Single submitter ⚠
- p.Ser296Leu Single submitter ⚠
- p.Ser344Leu Single submitter ⚠
- p.Thr172Ile Single submitter ⚠
- p.Thr172Ser Single submitter ⚠
- p.Thr198Ser Single submitter ⚠
- p.Thr299Asn Single submitter ⚠
- p.Thr389Met Single submitter ⚠
- p.Thr52Ile Single submitter ⚠
- p.Thr58Asn Single submitter ⚠
- p.Tyr192Cys Single submitter ⚠
- p.Tyr24Cys Single submitter
- p.Val216Leu Single submitter ⚠
- p.Val267Ala Single submitter ⚠
- p.Val295Glu Single submitter ⚠
- p.Val295Met Single submitter ⚠
- p.Val351Ile Single submitter ⚠
- p.Val35Ile Single submitter ⚠
- p.Val369Met Single submitter ⚠
- p.Val392Leu Single submitter ⚠