TUBGCP3 — 106 ClinVar variants
All ClinVar germline TUBGCP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
1 Benign · 8 Likely benign · 97 Uncertain significance
Full TUBGCP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TUBGCP3 p.Ala134Thr Uncertain significance Single submitter
- TUBGCP3 p.Ala176Val Uncertain significance Single submitter
- TUBGCP3 p.Ala399Val Uncertain significance Single submitter
- TUBGCP3 p.Arg105His Uncertain significance Single submitter
- TUBGCP3 p.Arg106Gly Uncertain significance Single submitter
- TUBGCP3 p.Arg146Trp Uncertain significance Single submitter
- TUBGCP3 p.Arg202Gln Uncertain significance Single submitter
- TUBGCP3 p.Arg228Cys Uncertain significance Single submitter
- TUBGCP3 p.Arg228His Uncertain significance Single submitter
- TUBGCP3 p.Arg337Gln Uncertain significance Single submitter
- TUBGCP3 p.Arg365Gln Uncertain significance Single submitter
- TUBGCP3 p.Arg366His Uncertain significance Single submitter
- TUBGCP3 p.Arg66Gln Uncertain significance Single submitter
- TUBGCP3 p.Arg794Gly Uncertain significance Single submitter
- TUBGCP3 p.Arg848Leu Uncertain significance Single submitter
- TUBGCP3 p.Arg874Gln Uncertain significance Single submitter
- TUBGCP3 p.Arg894Cys Uncertain significance Single submitter
- TUBGCP3 p.Arg902Trp Uncertain significance Single submitter
- TUBGCP3 p.Arg903Cys Uncertain significance Single submitter
- TUBGCP3 p.Arg903Pro Uncertain significance Single submitter
- TUBGCP3 p.Asn229Asp Uncertain significance Single submitter
- TUBGCP3 p.Asn355Ser Uncertain significance Single submitter
- TUBGCP3 p.Asn550Ser Uncertain significance Single submitter
- TUBGCP3 p.Asp125Asn Uncertain significance Single submitter
- TUBGCP3 p.Asp193Gly Uncertain significance Single submitter
- TUBGCP3 p.Asp27Ala Uncertain significance Single submitter
- TUBGCP3 p.Asp478Gly Uncertain significance Single submitter
- TUBGCP3 p.Asp521Gly Uncertain significance Single submitter
- TUBGCP3 p.Asp525Glu Uncertain significance Single submitter
- TUBGCP3 p.Asp756Gly Uncertain significance Single submitter
- TUBGCP3 p.Gln149Arg Uncertain significance Single submitter
- TUBGCP3 p.Gln178Leu Uncertain significance Single submitter
- TUBGCP3 p.Gln703Arg Uncertain significance Single submitter
- TUBGCP3 p.Gln805His Uncertain significance Single submitter
- TUBGCP3 p.Gln84Leu Uncertain significance Single submitter
- TUBGCP3 p.Glu61Gly Uncertain significance Single submitter
- TUBGCP3 p.Gly155Ser Uncertain significance Single submitter
- TUBGCP3 p.Gly353Cys Uncertain significance Single submitter
- TUBGCP3 p.Gly353Val Uncertain significance Single submitter
- TUBGCP3 p.His746Asp Uncertain significance Single submitter
- TUBGCP3 p.Ile266Val Uncertain significance Single submitter
- TUBGCP3 p.Ile63Thr Uncertain significance Single submitter
- TUBGCP3 p.Ile648Thr Uncertain significance Single submitter
- TUBGCP3 p.Ile680Val Uncertain significance Single submitter
- TUBGCP3 p.Ile782Ser Uncertain significance Single submitter
- TUBGCP3 p.Ile93Val Uncertain significance Single submitter
- TUBGCP3 p.Leu181Phe Uncertain significance Single submitter
- TUBGCP3 p.Leu368Met Uncertain significance Single submitter
- TUBGCP3 p.Leu626Pro Uncertain significance Single submitter
- TUBGCP3 p.Lys276Arg Uncertain significance Single submitter
- TUBGCP3 p.Lys533Asn Uncertain significance Single submitter
- TUBGCP3 p.Lys809Gln Uncertain significance Single submitter
- TUBGCP3 p.Met506Thr Uncertain significance Single submitter
- TUBGCP3 p.Pro136Ser Uncertain significance Single submitter
- TUBGCP3 p.Ser361Asn Uncertain significance Single submitter
- TUBGCP3 p.Ser428Arg Uncertain significance Single submitter
- TUBGCP3 p.Ser845Pro Uncertain significance Single submitter
- TUBGCP3 p.Ser904Ile Uncertain significance Single submitter
- TUBGCP3 p.Ser99Asn Uncertain significance Single submitter
- TUBGCP3 p.Thr206Ile Uncertain significance Single submitter
- TUBGCP3 p.Thr208Ile Uncertain significance Single submitter
- TUBGCP3 p.Thr217Ala Uncertain significance Single submitter
- TUBGCP3 p.Thr239Met Uncertain significance Single submitter
- TUBGCP3 p.Thr271Ser Uncertain significance Single submitter
- TUBGCP3 p.Thr453Ala Uncertain significance Single submitter
- TUBGCP3 p.Thr678Ala Uncertain significance Single submitter
- TUBGCP3 p.Thr822Lys Uncertain significance Single submitter
- TUBGCP3 p.Thr822Met Uncertain significance Single submitter
- TUBGCP3 p.Trp433Arg Uncertain significance Single submitter
- TUBGCP3 p.Tyr133His Uncertain significance Single submitter
- TUBGCP3 p.Tyr372Cys Uncertain significance Single submitter
- TUBGCP3 p.Val257Ile Uncertain significance Single submitter
- TUBGCP3 p.Val320Ile Uncertain significance Single submitter
- TUBGCP3 p.Val47Ile Uncertain significance Single submitter
- TUBGCP3 p.Val637Phe Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- TUBGCP3 p.Ala204Thr Uncertain significance Single submitter
- TUBGCP3 p.Arg315Cys Uncertain significance Single submitter
- TUBGCP3 p.Arg315Ser Uncertain significance Single submitter
- TUBGCP3 p.Arg377Gln Uncertain significance Single submitter
- TUBGCP3 p.Arg432His Uncertain significance Single submitter
- TUBGCP3 p.Arg587Cys Uncertain significance Single submitter
- TUBGCP3 p.Arg761Cys Uncertain significance Single submitter
- TUBGCP3 p.Arg813Gly Uncertain significance Single submitter
- TUBGCP3 p.Cys656Arg Uncertain significance Single submitter
- TUBGCP3 p.Gln479Arg Uncertain significance Single submitter
- TUBGCP3 p.Gly263Ser Uncertain significance Single submitter
- TUBGCP3 p.Gly390Glu Uncertain significance Single submitter
- TUBGCP3 p.His751Gln Uncertain significance Single submitter
- TUBGCP3 p.Ile261Val Uncertain significance Single submitter
- TUBGCP3 p.Ser760Pro Uncertain significance Single submitter
- TUBGCP3 p.Thr129Asn Uncertain significance Single submitter
- TUBGCP3 p.Tyr335His Uncertain significance Single submitter
All TUBGCP3 variants
Benign 1
- c.1168+37CGCGCGACTTTCCCA[2] Single submitter
Likely benign 8
- c.1168+20C>T Single submitter
- c.1168+73_1168+102del Single submitter
- p.Asp645= Single submitter
- p.Gly183= Single submitter
- p.Ile706Val Single submitter
- p.Leu640= Single submitter
- p.Ser142Asn Single submitter
- p.Ser766Gly Single submitter
Uncertain significance 97
- p.Ala134Thr Single submitter ⚠
- p.Ala176Val Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala399Val Single submitter ⚠
- p.Arg105His Single submitter ⚠
- p.Arg106Gly Single submitter ⚠
- p.Arg146Trp Single submitter ⚠
- p.Arg202Gln Single submitter ⚠
- p.Arg228Cys Single submitter ⚠
- p.Arg228His Single submitter ⚠
- p.Arg315Cys Single submitter ⚠
- p.Arg315Ser Single submitter ⚠
- p.Arg337Gln Single submitter ⚠
- p.Arg365Gln Single submitter ⚠
- p.Arg366His Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg432His Single submitter ⚠
- p.Arg587Cys Single submitter ⚠
- p.Arg66Gln Single submitter ⚠
- p.Arg761Cys Single submitter ⚠
- p.Arg794Gly Single submitter ⚠
- p.Arg813Gly Single submitter ⚠
- p.Arg848Leu Single submitter ⚠
- p.Arg874Gln Single submitter ⚠
- p.Arg894Cys Single submitter ⚠
- p.Arg902Trp Single submitter ⚠
- p.Arg903Cys Single submitter ⚠
- p.Arg903Pro Single submitter ⚠
- p.Asn229Asp Single submitter ⚠
- p.Asn355Ser Single submitter ⚠
- p.Asn550Ser Single submitter ⚠
- p.Asp125Asn Single submitter ⚠
- p.Asp193Gly Single submitter ⚠
- p.Asp27Ala Single submitter ⚠
- p.Asp478Gly Single submitter ⚠
- p.Asp521Gly Single submitter ⚠
- p.Asp525Glu Single submitter ⚠
- p.Asp756Gly Single submitter ⚠
- p.Cys656Arg Single submitter ⚠
- p.Gln149Arg Single submitter ⚠
- p.Gln178Leu Single submitter ⚠
- p.Gln479Arg Single submitter ⚠
- p.Gln703Arg Single submitter ⚠
- p.Gln805His Single submitter ⚠
- p.Gln84Leu Single submitter ⚠
- p.Glu61Gly Single submitter ⚠
- p.Gly155Ser Single submitter ⚠
- p.Gly263Ser Single submitter ⚠
- p.Gly353Cys Single submitter ⚠
- p.Gly353Val Single submitter ⚠
- p.Gly390Glu Single submitter ⚠
- p.His424Pro Single submitter
- p.His444Leu Single submitter
- p.His746Asp Single submitter ⚠
- p.His751Gln Single submitter ⚠
- p.Ile261Val Single submitter ⚠
- p.Ile266Val Single submitter ⚠
- p.Ile63Thr Single submitter ⚠
- p.Ile648Thr Single submitter ⚠
- p.Ile680Val Single submitter ⚠
- p.Ile782Ser Single submitter ⚠
- p.Ile93Val Single submitter ⚠
- p.Leu181Phe Single submitter ⚠
- p.Leu368Met Single submitter ⚠
- p.Leu626Pro Single submitter ⚠
- p.Lys276Arg Single submitter ⚠
- p.Lys533Asn Single submitter ⚠
- p.Lys809Gln Single submitter ⚠
- p.Met506Thr Single submitter ⚠
- p.Pro136Ser Single submitter ⚠
- p.Pro409Leu Single submitter
- p.Pro409Ser Single submitter
- p.Ser361Asn Single submitter ⚠
- p.Ser428Arg Single submitter ⚠
- p.Ser760Pro Single submitter ⚠
- p.Ser845Pro Single submitter ⚠
- p.Ser904Ile Single submitter ⚠
- p.Ser99Asn Single submitter ⚠
- p.Thr129Asn Single submitter ⚠
- p.Thr206Ile Single submitter ⚠
- p.Thr208Ile Single submitter ⚠
- p.Thr217Ala Single submitter ⚠
- p.Thr239Met Single submitter ⚠
- p.Thr271Ser Single submitter ⚠
- p.Thr453Ala Single submitter ⚠
- p.Thr678Ala Single submitter ⚠
- p.Thr822Lys Single submitter ⚠
- p.Thr822Met Single submitter ⚠
- p.Trp433Arg Single submitter ⚠
- p.Tyr133His Single submitter ⚠
- p.Tyr335His Single submitter ⚠
- p.Tyr372Cys Single submitter ⚠
- p.Tyr675Cys Single submitter
- p.Val257Ile Single submitter ⚠
- p.Val320Ile Single submitter ⚠
- p.Val47Ile Single submitter ⚠
- p.Val637Phe Single submitter ⚠