TXK — 69 ClinVar variants
All ClinVar germline TXK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
69 Uncertain significance
Full TXK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TXK p.Ala172Ser Uncertain significance Single submitter
- TXK p.Ala192Val Uncertain significance Single submitter
- TXK p.Ala519Thr Uncertain significance Single submitter
- TXK p.Arg394Gly Uncertain significance Single submitter
- TXK p.Arg518Trp Uncertain significance Single submitter
- TXK p.Cys333Arg Uncertain significance Single submitter
- TXK p.Cys396Tyr Uncertain significance Single submitter
- TXK p.Gln10Arg Uncertain significance Single submitter
- TXK p.Gln29Glu Uncertain significance Single submitter
- TXK p.Glu309Asp Uncertain significance Single submitter
- TXK p.Gly247Glu Uncertain significance Single submitter
- TXK p.Gly280Asp Uncertain significance Single submitter
- TXK p.Gly280Cys Uncertain significance Single submitter
- TXK p.His293Tyr Uncertain significance Single submitter
- TXK p.His388Gln Uncertain significance Single submitter
- TXK p.His504Gln Uncertain significance Single submitter
- TXK p.Ile403Val Uncertain significance Single submitter
- TXK p.Ile479Val Uncertain significance Single submitter
- TXK p.Lys320Arg Uncertain significance Single submitter
- TXK p.Lys320Gln Uncertain significance Single submitter
- TXK p.Lys364Glu Uncertain significance Single submitter
- TXK p.Lys431Asn Uncertain significance Single submitter
- TXK p.Met239Val Uncertain significance Single submitter
- TXK p.Met493Val Uncertain significance Single submitter
- TXK p.Phe13Ser Uncertain significance Single submitter
- TXK p.Phe483Leu Uncertain significance Single submitter
- TXK p.Ser11Leu Uncertain significance Single submitter
- TXK p.Ser399Gly Uncertain significance Single submitter
- TXK p.Ser399Ile Uncertain significance Single submitter
- TXK p.Thr8Ile Uncertain significance Single submitter
- TXK p.Val415Ile Uncertain significance Single submitter
- TXK p.Val454Asp Uncertain significance Single submitter
- TXK p.Val476Met Uncertain significance Single submitter
- TXK p.Val520Asp Uncertain significance Single submitter
Predictors split 35
The independent predictors disagree with each other — read with care.
- TXK p.Ala160Val Uncertain significance Single submitter
- TXK p.Ala491Thr Uncertain significance Single submitter
- TXK p.Ala514Val Uncertain significance Single submitter
- TXK p.Ala524Glu Uncertain significance Single submitter
- TXK p.Arg241His Uncertain significance Single submitter
- TXK p.Arg291Trp Uncertain significance Single submitter
- TXK p.Arg487Leu Uncertain significance Single submitter
- TXK p.Asn302Ser Uncertain significance Single submitter
- TXK p.Asn472Asp Uncertain significance Single submitter
- TXK p.Asn472His Uncertain significance Single submitter
- TXK p.Asp310Val Uncertain significance Single submitter
- TXK p.Cys17Arg Uncertain significance Single submitter
- TXK p.Cys19Tyr Uncertain significance Single submitter
- TXK p.Glu265Lys Uncertain significance Single submitter
- TXK p.Glu313Asp Uncertain significance Single submitter
- TXK p.Glu505Val Uncertain significance Single submitter
- TXK p.Glu515Lys Uncertain significance Single submitter
- TXK p.Gly182Arg Uncertain significance Single submitter
- TXK p.Gly250Cys Uncertain significance Single submitter
- TXK p.Gly385Asp Uncertain significance Single submitter
- TXK p.His152Arg Uncertain significance Single submitter
- TXK p.His152Tyr Uncertain significance Single submitter
- TXK p.Ile406Leu Uncertain significance Single submitter
- TXK p.Leu287Val Uncertain significance Single submitter
- TXK p.Leu368Gln Uncertain significance Single submitter
- TXK p.Lys427Arg Uncertain significance Single submitter
- TXK p.Phe440Ser Uncertain significance Single submitter
- TXK p.Pro507Thr Uncertain significance Single submitter
- TXK p.Ser279Asn Uncertain significance Single submitter
- TXK p.Ser400Leu Uncertain significance Single submitter
- TXK p.Ser422Gly Uncertain significance Single submitter
- TXK p.Tyr148His Uncertain significance Single submitter
- TXK p.Tyr354Ser Uncertain significance Single submitter
- TXK p.Tyr386Cys Uncertain significance Single submitter
- TXK p.Val188Ile Uncertain significance Single submitter
All TXK variants
Uncertain significance 69
- p.Ala160Val Single submitter ⚠
- p.Ala172Ser Single submitter ⚠
- p.Ala192Val Single submitter ⚠
- p.Ala491Thr Single submitter ⚠
- p.Ala514Val Single submitter ⚠
- p.Ala519Thr Single submitter ⚠
- p.Ala524Glu Single submitter ⚠
- p.Arg241His Single submitter ⚠
- p.Arg291Trp Single submitter ⚠
- p.Arg394Gly Single submitter ⚠
- p.Arg487Leu Single submitter ⚠
- p.Arg518Trp Single submitter ⚠
- p.Asn302Ser Single submitter ⚠
- p.Asn472Asp Single submitter ⚠
- p.Asn472His Single submitter ⚠
- p.Asp310Val Single submitter ⚠
- p.Cys17Arg Single submitter ⚠
- p.Cys19Tyr Single submitter ⚠
- p.Cys333Arg Single submitter ⚠
- p.Cys396Tyr Single submitter ⚠
- p.Gln10Arg Single submitter ⚠
- p.Gln29Glu Single submitter ⚠
- p.Glu265Lys Single submitter ⚠
- p.Glu309Asp Single submitter ⚠
- p.Glu313Asp Single submitter ⚠
- p.Glu505Val Single submitter ⚠
- p.Glu515Lys Single submitter ⚠
- p.Gly182Arg Single submitter ⚠
- p.Gly247Glu Single submitter ⚠
- p.Gly250Cys Single submitter ⚠
- p.Gly280Asp Single submitter ⚠
- p.Gly280Cys Single submitter ⚠
- p.Gly385Asp Single submitter ⚠
- p.His152Arg Single submitter ⚠
- p.His152Tyr Single submitter ⚠
- p.His293Tyr Single submitter ⚠
- p.His388Gln Single submitter ⚠
- p.His504Gln Single submitter ⚠
- p.Ile403Val Single submitter ⚠
- p.Ile406Leu Single submitter ⚠
- p.Ile479Val Single submitter ⚠
- p.Leu287Val Single submitter ⚠
- p.Leu368Gln Single submitter ⚠
- p.Lys320Arg Single submitter ⚠
- p.Lys320Gln Single submitter ⚠
- p.Lys364Glu Single submitter ⚠
- p.Lys427Arg Single submitter ⚠
- p.Lys431Asn Single submitter ⚠
- p.Met239Val Single submitter ⚠
- p.Met493Val Single submitter ⚠
- p.Phe13Ser Single submitter ⚠
- p.Phe440Ser Single submitter ⚠
- p.Phe483Leu Single submitter ⚠
- p.Pro507Thr Single submitter ⚠
- p.Ser11Leu Single submitter ⚠
- p.Ser279Asn Single submitter ⚠
- p.Ser399Gly Single submitter ⚠
- p.Ser399Ile Single submitter ⚠
- p.Ser400Leu Single submitter ⚠
- p.Ser422Gly Single submitter ⚠
- p.Thr8Ile Single submitter ⚠
- p.Tyr148His Single submitter ⚠
- p.Tyr354Ser Single submitter ⚠
- p.Tyr386Cys Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val415Ile Single submitter ⚠
- p.Val454Asp Single submitter ⚠
- p.Val476Met Single submitter ⚠
- p.Val520Asp Single submitter ⚠