U2SURP — 62 ClinVar variants
All ClinVar germline U2SURP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
1 Benign · 61 Uncertain significance
Full U2SURP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- U2SURP p.Ala165Thr Uncertain significance Single submitter
- U2SURP p.Ala247Thr Uncertain significance Single submitter
- U2SURP p.Arg44Trp Uncertain significance Single submitter
- U2SURP p.Arg46Gln Uncertain significance Single submitter
- U2SURP p.Arg490Trp Uncertain significance Single submitter
- U2SURP p.Arg495Pro Uncertain significance Single submitter
- U2SURP p.Arg61Cys Uncertain significance Single submitter
- U2SURP p.Arg968Lys Uncertain significance Single submitter
- U2SURP p.Arg999Gln Uncertain significance Single submitter
- U2SURP p.Asn680Thr Uncertain significance Single submitter
- U2SURP p.Asn79Ser Uncertain significance Single submitter
- U2SURP p.Asp166Glu Uncertain significance Single submitter
- U2SURP p.Asp689Asn Uncertain significance Single submitter
- U2SURP p.Gln10Glu Uncertain significance Single submitter
- U2SURP p.Gln173His Uncertain significance Single submitter
- U2SURP p.Gln235Glu Uncertain significance Single submitter
- U2SURP p.Glu492Asp Uncertain significance Single submitter
- U2SURP p.Glu766Lys Uncertain significance Single submitter
- U2SURP p.Glu792Gln Uncertain significance Single submitter
- U2SURP p.Gly8Val Uncertain significance Single submitter
- U2SURP p.His30Arg Uncertain significance Single submitter
- U2SURP p.His53Tyr Uncertain significance Single submitter
- U2SURP p.Ile753Val Uncertain significance Single submitter
- U2SURP p.Lys336Arg Uncertain significance Single submitter
- U2SURP p.Lys535Gln Uncertain significance Single submitter
- U2SURP p.Lys99Arg Uncertain significance Single submitter
- U2SURP p.Met342Ile Uncertain significance Single submitter
- U2SURP p.Met342Leu Uncertain significance Single submitter
- U2SURP p.Met825Ile Uncertain significance Single submitter
- U2SURP p.Pro248Thr Uncertain significance Single submitter
- U2SURP p.Pro263Ser Uncertain significance Single submitter
- U2SURP p.Pro36Leu Uncertain significance Single submitter
- U2SURP p.Pro400Leu Uncertain significance Single submitter
- U2SURP p.Pro6Ser Uncertain significance Single submitter
- U2SURP p.Pro720Arg Uncertain significance Single submitter
- U2SURP p.Pro867Leu Uncertain significance Single submitter
- U2SURP p.Pro867Thr Uncertain significance Single submitter
- U2SURP p.Pro933Ala Uncertain significance Single submitter
- U2SURP p.Ser14Thr Uncertain significance Single submitter
- U2SURP p.Ser39Asn Uncertain significance Single submitter
- U2SURP p.Ser800Asn Uncertain significance Single submitter
- U2SURP p.Ser834Pro Uncertain significance Single submitter
- U2SURP p.Thr719Ile Uncertain significance Single submitter
- U2SURP p.Tyr478Cys Uncertain significance Single submitter
- U2SURP p.Tyr603His Uncertain significance Single submitter
- U2SURP p.Val21Ile Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- U2SURP p.Ala656Val Uncertain significance Single submitter
- U2SURP p.Arg1001Ser Uncertain significance Single submitter
- U2SURP p.Arg490Gln Uncertain significance Single submitter
- U2SURP p.Arg956His Uncertain significance Single submitter
- U2SURP p.Arg999Leu Uncertain significance Single submitter
- U2SURP p.Asn631Ser Uncertain significance Single submitter
- U2SURP p.Asp484Glu Uncertain significance Single submitter
- U2SURP p.Glu896Gly Uncertain significance Single submitter
- U2SURP p.Lys865Glu Uncertain significance Single submitter
- U2SURP p.Ser127Arg Uncertain significance Single submitter
- U2SURP p.Ser202Gly Uncertain significance Single submitter
- U2SURP p.Ser485Cys Uncertain significance Single submitter
- U2SURP p.Ser837Arg Uncertain significance Single submitter
- U2SURP p.Thr491Met Uncertain significance Single submitter
All U2SURP variants
Benign 1
- p.Ser606= Multiple submitters
Uncertain significance 61
- p.Ala165Thr Single submitter ⚠
- p.Ala247Thr Single submitter ⚠
- p.Ala656Val Single submitter ⚠
- p.Arg1001Ser Single submitter ⚠
- p.Arg44Trp Single submitter ⚠
- p.Arg46Gln Single submitter ⚠
- p.Arg490Gln Single submitter ⚠
- p.Arg490Trp Single submitter ⚠
- p.Arg495Pro Single submitter ⚠
- p.Arg61Cys Single submitter ⚠
- p.Arg956His Single submitter ⚠
- p.Arg968Lys Single submitter ⚠
- p.Arg999Gln Single submitter ⚠
- p.Arg999Leu Single submitter ⚠
- p.Asn631Ser Single submitter ⚠
- p.Asn680Thr Single submitter ⚠
- p.Asn79Ser Single submitter ⚠
- p.Asp166Glu Single submitter ⚠
- p.Asp484Glu Single submitter ⚠
- p.Asp689Asn Single submitter ⚠
- p.Gln10Glu Single submitter ⚠
- p.Gln173His Single submitter ⚠
- p.Gln235Glu Single submitter ⚠
- p.Glu492Asp Single submitter ⚠
- p.Glu766Lys Single submitter ⚠
- p.Glu792Gln Single submitter ⚠
- p.Glu896Gly Single submitter ⚠
- p.Gly8Val Single submitter ⚠
- p.His30Arg Single submitter ⚠
- p.His53Tyr Single submitter ⚠
- p.Ile753Val Single submitter ⚠
- p.Lys336Arg Single submitter ⚠
- p.Lys535Gln Single submitter ⚠
- p.Lys865Glu Single submitter ⚠
- p.Lys99Arg Single submitter ⚠
- p.Met342Ile Single submitter ⚠
- p.Met342Leu Single submitter ⚠
- p.Met825Ile Single submitter ⚠
- p.Pro248Thr Single submitter ⚠
- p.Pro263Ser Single submitter ⚠
- p.Pro36Leu Single submitter ⚠
- p.Pro400Leu Single submitter ⚠
- p.Pro6Ser Single submitter ⚠
- p.Pro720Arg Single submitter ⚠
- p.Pro867Leu Single submitter ⚠
- p.Pro867Thr Single submitter ⚠
- p.Pro933Ala Single submitter ⚠
- p.Ser127Arg Single submitter ⚠
- p.Ser14Thr Single submitter ⚠
- p.Ser202Gly Single submitter ⚠
- p.Ser39Asn Single submitter ⚠
- p.Ser485Cys Single submitter ⚠
- p.Ser800Asn Single submitter ⚠
- p.Ser834Pro Single submitter ⚠
- p.Ser837Arg Single submitter ⚠
- p.Thr150_Asp151insTer Single submitter
- p.Thr491Met Single submitter ⚠
- p.Thr719Ile Single submitter ⚠
- p.Tyr478Cys Single submitter ⚠
- p.Tyr603His Single submitter ⚠
- p.Val21Ile Single submitter ⚠