UBE2B — 4 ClinVar variants
All ClinVar germline UBE2B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
1 Likely benign · 3 Uncertain significance
Full UBE2B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All UBE2B variants
Likely benign 1
- c.331-9TCC[3] No assertion criteria UBE2B-related disorder
Uncertain significance 3
- p.Ala143Ser Single submitter ⚠
- p.Asn150Ser Single submitter ⚠
- p.Ile105Val Single submitter ⚠