UBE2E1 — 8 ClinVar variants
All ClinVar germline UBE2E1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 6 flagged for review →
1 Benign · 1 Benign/Likely benign · 6 Uncertain significance
Full UBE2E1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 6
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 4
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 2
The independent predictors disagree with each other — read with care.
All UBE2E1 variants
Benign 1
- p.Asn138= Multiple submitters
Benign/Likely benign 1
- p.Gly73= Multiple submitters
Uncertain significance 6
- p.Lys32Arg Single submitter ⚠
- p.Lys32Asn Single submitter ⚠
- p.Pro104Thr Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr28Asn Single submitter ⚠
- p.Tyr173Cys Single submitter ⚠