UBE2G2 — 19 ClinVar variants
All ClinVar germline UBE2G2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
19 Uncertain significance
Full UBE2G2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UBE2G2 p.Ala107Val Uncertain significance Single submitter
- UBE2G2 p.Arg148Gln Uncertain significance Single submitter
- UBE2G2 p.Asn131Ser Uncertain significance Single submitter
- UBE2G2 p.Asp146Asn Uncertain significance Single submitter
- UBE2G2 p.Asp85Val Uncertain significance Single submitter
- UBE2G2 p.Asp98Asn Uncertain significance Single submitter
- UBE2G2 p.Glu149Gly Uncertain significance Single submitter
- UBE2G2 p.Ile154Leu Uncertain significance Single submitter
- UBE2G2 p.Ile154Val Uncertain significance Single submitter
- UBE2G2 p.Leu62Val Uncertain significance Single submitter
- UBE2G2 p.Lys7Glu Uncertain significance Single submitter
- UBE2G2 p.Pro20Thr Uncertain significance Single submitter
- UBE2G2 p.Ser91Tyr Uncertain significance Single submitter
- UBE2G2 p.Val116Met Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All UBE2G2 variants
Uncertain significance 19
- p.Ala107Val Single submitter ⚠
- p.Ala39Thr Single submitter ⚠
- p.Ala95Val Single submitter
- p.Arg148Gln Single submitter ⚠
- p.Asn131Ser Single submitter ⚠
- p.Asp146Asn Single submitter ⚠
- p.Asp85Val Single submitter ⚠
- p.Asp98Asn Single submitter ⚠
- p.Glu149Gly Single submitter ⚠
- p.Ile154Leu Single submitter ⚠
- p.Ile154Val Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Lys7Glu Single submitter ⚠
- p.Pro20Ala Single submitter ⚠
- p.Pro20Thr Single submitter ⚠
- p.Ser91Tyr Single submitter ⚠
- p.Thr74Pro Single submitter ⚠
- p.Trp110Ter Single submitter
- p.Val116Met Single submitter ⚠