UBE2L6 — 25 ClinVar variants
All ClinVar germline UBE2L6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
2 Likely benign · 23 Uncertain significance
Full UBE2L6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UBE2L6 p.Ala107Thr Uncertain significance Single submitter
- UBE2L6 p.Asn109His Uncertain significance Single submitter
- UBE2L6 p.Asn31Ser Uncertain significance Single submitter
- UBE2L6 p.Asn52Lys Uncertain significance Single submitter
- UBE2L6 p.Asp13Asn Uncertain significance Single submitter
- UBE2L6 p.His36Gln Uncertain significance Single submitter
- UBE2L6 p.Ile55Asn Uncertain significance Single submitter
- UBE2L6 p.Ile89Val Uncertain significance Single submitter
- UBE2L6 p.Leu108Val Uncertain significance Single submitter
- UBE2L6 p.Leu87Met Uncertain significance Single submitter
- UBE2L6 p.Pro59Leu Uncertain significance Single submitter
- UBE2L6 p.Ser91Asn Uncertain significance Single submitter
- UBE2L6 p.Tyr61Cys Uncertain significance Single submitter
- UBE2L6 p.Val32Ile Uncertain significance Single submitter
- UBE2L6 p.Val79Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- UBE2L6 p.Arg122Gln Uncertain significance Single submitter
- UBE2L6 p.Arg122Trp Uncertain significance Single submitter
- UBE2L6 p.Asp80Glu Uncertain significance Single submitter
- UBE2L6 p.Glu81Lys Uncertain significance Single submitter
- UBE2L6 p.Lys100Asn Uncertain significance Single submitter
- UBE2L6 p.Phe51Leu Uncertain significance Single submitter
- UBE2L6 p.Pro115Leu Uncertain significance Single submitter
All UBE2L6 variants
Likely benign 2
- p.Asn109Ser Single submitter
- p.Lys17Glu Single submitter
Uncertain significance 23
- p.Ala107Thr Single submitter ⚠
- p.Arg122Gln Single submitter ⚠
- p.Arg122Trp Single submitter ⚠
- p.Asn109His Single submitter ⚠
- p.Asn31Ser Single submitter ⚠
- p.Asn52Lys Single submitter ⚠
- p.Asp13Asn Single submitter ⚠
- p.Asp80Glu Single submitter ⚠
- p.Glu81Lys Single submitter ⚠
- p.His36Gln Single submitter ⚠
- p.Ile55Asn Single submitter ⚠
- p.Ile89Val Single submitter ⚠
- p.Leu108Val Single submitter ⚠
- p.Leu87Met Single submitter ⚠
- p.Lys100Asn Single submitter ⚠
- p.Lys9Thr Single submitter
- p.Phe51Leu Single submitter ⚠
- p.Pro115Leu Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Ser91Asn Single submitter ⚠
- p.Tyr61Cys Single submitter ⚠
- p.Val32Ile Single submitter ⚠
- p.Val79Met Single submitter ⚠