UBE2M — 10 ClinVar variants
All ClinVar germline UBE2M variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 10 flagged for review →
10 Uncertain significance
Full UBE2M gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 10
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 9
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UBE2M p.Ala149Val Uncertain significance Single submitter
- UBE2M p.Arg166His Uncertain significance Single submitter
- UBE2M p.Gln165His Uncertain significance Single submitter
- UBE2M p.Ile128Val Uncertain significance Single submitter
- UBE2M p.Ile173Val Uncertain significance Single submitter
- UBE2M p.Lys11Gln Uncertain significance Single submitter
- UBE2M p.Pro54Thr Uncertain significance Single submitter
- UBE2M p.Ser73Asn Uncertain significance Single submitter
- UBE2M p.Ser79Thr Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All UBE2M variants
Uncertain significance 10
- p.Ala149Val Single submitter ⚠
- p.Arg166His Single submitter ⚠
- p.Gln165His Single submitter ⚠
- p.Ile128Val Single submitter ⚠
- p.Ile173Val Single submitter ⚠
- p.Lys11Gln Single submitter ⚠
- p.Lys12Glu Single submitter ⚠
- p.Pro54Thr Single submitter ⚠
- p.Ser73Asn Single submitter ⚠
- p.Ser79Thr Single submitter ⚠