UBE2N — 7 ClinVar variants
All ClinVar germline UBE2N variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 7 flagged for review →
7 Uncertain significance
Full UBE2N gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 7
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 6
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UBE2N p.Asn116Ser Uncertain significance Single submitter
- UBE2N p.Asn123Ser Uncertain significance Single submitter
- UBE2N p.Ile108Met Uncertain significance Single submitter
- UBE2N p.Lys130Glu Uncertain significance Single submitter
- UBE2N p.Pro21Thr Uncertain significance Single submitter
- UBE2N p.Ser113Gly Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All UBE2N variants
Uncertain significance 7
- p.Asn116Ser Single submitter ⚠
- p.Asn123Ser Single submitter ⚠
- p.Ile108Met Single submitter ⚠
- p.Lys130Glu Single submitter ⚠
- p.Pro21Thr Single submitter ⚠
- p.Ser113Gly Single submitter ⚠
- p.Thr103Ala Single submitter ⚠