UBLCP1 — 32 ClinVar variants
All ClinVar germline UBLCP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
32 Uncertain significance
Full UBLCP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UBLCP1 p.Ala203Glu Uncertain significance Single submitter
- UBLCP1 p.Ala203Thr Uncertain significance Single submitter
- UBLCP1 p.Ala274Val Uncertain significance Single submitter
- UBLCP1 p.Arg134Met Uncertain significance Single submitter
- UBLCP1 p.Arg134Ser Uncertain significance Single submitter
- UBLCP1 p.Arg223Gly Uncertain significance Single submitter
- UBLCP1 p.Arg223Lys Uncertain significance Single submitter
- UBLCP1 p.Asn186Thr Uncertain significance Single submitter
- UBLCP1 p.Asp178Asn Uncertain significance Single submitter
- UBLCP1 p.Asp93Gly Uncertain significance Single submitter
- UBLCP1 p.Glu124Gln Uncertain significance Single submitter
- UBLCP1 p.Glu293Asp Uncertain significance Single submitter
- UBLCP1 p.Gly317Val Uncertain significance Single submitter
- UBLCP1 p.His305Tyr Uncertain significance Single submitter
- UBLCP1 p.Ile235Val Uncertain significance Single submitter
- UBLCP1 p.Ile249Val Uncertain significance Single submitter
- UBLCP1 p.Lys314Arg Uncertain significance Single submitter
- UBLCP1 p.Lys33Arg Uncertain significance Single submitter
- UBLCP1 p.Lys65Ile Uncertain significance Single submitter
- UBLCP1 p.Pro164Thr Uncertain significance Single submitter
- UBLCP1 p.Trp182Leu Uncertain significance Single submitter
- UBLCP1 p.Val106Phe Uncertain significance Single submitter
- UBLCP1 p.Val50Leu Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All UBLCP1 variants
Uncertain significance 32
- c.685-1G>C Single submitter
- c.929+1G>C Single submitter
- p.Ala173Val Single submitter
- p.Ala203Glu Single submitter ⚠
- p.Ala203Thr Single submitter ⚠
- p.Ala274Val Single submitter ⚠
- p.Arg134Met Single submitter ⚠
- p.Arg134Ser Single submitter ⚠
- p.Arg223Gly Single submitter ⚠
- p.Arg223Lys Single submitter ⚠
- p.Arg78His Single submitter ⚠
- p.Asn186Thr Single submitter ⚠
- p.Asp178Asn Single submitter ⚠
- p.Asp93Gly Single submitter ⚠
- p.Cys154Tyr Single submitter ⚠
- p.Glu124Gln Single submitter ⚠
- p.Glu293Asp Single submitter ⚠
- p.Gly198Glu Single submitter ⚠
- p.Gly317Val Single submitter ⚠
- p.His305Tyr Single submitter ⚠
- p.Ile101Thr Single submitter
- p.Ile235Val Single submitter ⚠
- p.Ile249Val Single submitter ⚠
- p.Ile72Met Single submitter ⚠
- p.Leu48Phe Single submitter ⚠
- p.Lys314Arg Single submitter ⚠
- p.Lys33Arg Single submitter ⚠
- p.Lys65Ile Single submitter ⚠
- p.Pro164Thr Single submitter ⚠
- p.Trp182Leu Single submitter ⚠
- p.Val106Phe Single submitter ⚠
- p.Val50Leu Single submitter ⚠