Sugi Variant

Sugi Variant/UBR4

UBR4 — 608 ClinVar variants

All ClinVar germline UBR4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 286 flagged for review →

2 Likely pathogenic · 2 Conflicting · 49 Benign · 8 Benign/Likely benign · 84 Likely benign · 463 Uncertain significance

Full UBR4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 286

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 247

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 247

Predictors split 37

The independent predictors disagree with each other — read with care.

All UBR4 variants

Likely pathogenic 2

Conflicting classifications of pathogenicity 2

Benign 49

Benign/Likely benign 8

Likely benign 84

Uncertain significance 463

Showing the top 300 by review status; the full set is in the sitemap.