UCK2 — 18 ClinVar variants
All ClinVar germline UCK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 15 flagged for review →
1 Likely benign · 17 Uncertain significance
Full UCK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 15
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UCK2 p.Ala253Thr Uncertain significance Single submitter
- UCK2 p.Asn243Asp Uncertain significance Single submitter
- UCK2 p.Gln7His Uncertain significance Single submitter
- UCK2 p.Gly175Arg Uncertain significance Single submitter
- UCK2 p.Ile218Val Uncertain significance Single submitter
- UCK2 p.Pro260Leu Uncertain significance Single submitter
- UCK2 p.Ser5Gly Uncertain significance Single submitter
- UCK2 p.Ser70Leu Uncertain significance Single submitter
- UCK2 p.Thr69Ser Uncertain significance Single submitter
- UCK2 p.Tyr65Cys Uncertain significance Single submitter
- UCK2 p.Val111Met Uncertain significance Single submitter
- UCK2 p.Val145Leu Uncertain significance Single submitter
- UCK2 p.Val41Met Uncertain significance Single submitter
Predictors split 2
The independent predictors disagree with each other — read with care.
All UCK2 variants
Likely benign 1
- p.Arg52His Single submitter
Uncertain significance 17
- p.Ala253Thr Single submitter ⚠
- p.Asn243Asp Single submitter ⚠
- p.Gln7His Single submitter ⚠
- p.Glu173Lys Single submitter
- p.Gly175Arg Single submitter ⚠
- p.Ile109Met Single submitter
- p.Ile218Val Single submitter ⚠
- p.Phe81Leu Single submitter ⚠
- p.Pro260Leu Single submitter ⚠
- p.Ser116Phe Single submitter ⚠
- p.Ser5Gly Single submitter ⚠
- p.Ser70Leu Single submitter ⚠
- p.Thr69Ser Single submitter ⚠
- p.Tyr65Cys Single submitter ⚠
- p.Val111Met Single submitter ⚠
- p.Val145Leu Single submitter ⚠
- p.Val41Met Single submitter ⚠