Sugi Variant

Sugi Variant/UCP3

UCP3 — 204 ClinVar variants

All ClinVar germline UCP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →

3 Conflicting · 12 Benign · 4 Benign/Likely benign · 57 Likely benign · 128 Uncertain significance

Full UCP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 113

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 93

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 19

The independent predictors disagree with each other — read with care.

All UCP3 variants

Conflicting classifications of pathogenicity 3

Benign 12

Benign/Likely benign 4

Likely benign 57

Uncertain significance 128