UFL1 — 121 ClinVar variants
All ClinVar germline UFL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
3 Benign · 1 Likely benign · 117 Uncertain significance
Full UFL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 97
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
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UFL1 p.Pro705Arg
Uncertain significance
Multiple submitters
hereditary breast ovarian cancer syndrome
- UFL1 p.Ala124Ser Uncertain significance Single submitter
- UFL1 p.Ala299Val Uncertain significance Single submitter
- UFL1 p.Ala353Ser Uncertain significance Single submitter
- UFL1 p.Ala648Val Uncertain significance Single submitter
- UFL1 p.Arg191Cys Uncertain significance Single submitter
- UFL1 p.Arg229Cys Uncertain significance Single submitter
- UFL1 p.Arg30Leu Uncertain significance Single submitter
- UFL1 p.Arg377Cys Uncertain significance Single submitter
- UFL1 p.Arg377His Uncertain significance Single submitter
- UFL1 p.Arg433Lys Uncertain significance Single submitter
- UFL1 p.Arg533Gly Uncertain significance Single submitter
- UFL1 p.Asn226His Uncertain significance Single submitter
- UFL1 p.Asn631Asp Uncertain significance Single submitter
- UFL1 p.Asp270Glu Uncertain significance Single submitter
- UFL1 p.Asp650His Uncertain significance Single submitter
- UFL1 p.Asp723Gly Uncertain significance Single submitter
- UFL1 p.Cys300Tyr Uncertain significance Single submitter
- UFL1 p.Gln213Arg Uncertain significance Single submitter
- UFL1 p.Gln403His Uncertain significance Single submitter
- UFL1 p.Gln773His Uncertain significance Single submitter
- UFL1 p.Glu222Gly Uncertain significance Single submitter
- UFL1 p.Glu314Asp Uncertain significance Single submitter
- UFL1 p.Glu314Gly Uncertain significance Single submitter
- UFL1 p.Glu314Val Uncertain significance Single submitter
- UFL1 p.Glu336Asp Uncertain significance Single submitter
- UFL1 p.Glu46Asp Uncertain significance Single submitter
- UFL1 p.Glu515Lys Uncertain significance Single submitter
- UFL1 p.Glu618Gln Uncertain significance Single submitter
- UFL1 p.Glu636Asp Uncertain significance Single submitter
- UFL1 p.Glu636Lys Uncertain significance Single submitter
- UFL1 p.Glu647Gly Uncertain significance Single submitter
- UFL1 p.Glu69Lys Uncertain significance Single submitter
- UFL1 p.Glu6Ala Uncertain significance Single submitter
- UFL1 p.Glu7Gly Uncertain significance Single submitter
- UFL1 p.Gly135Ser Uncertain significance Single submitter
- UFL1 p.Gly228Arg Uncertain significance Single submitter
- UFL1 p.Gly320Arg Uncertain significance Single submitter
- UFL1 p.Gly452Glu Uncertain significance Single submitter
- UFL1 p.Gly532Val Uncertain significance Single submitter
- UFL1 p.Gly749Glu Uncertain significance Single submitter
- UFL1 p.His489Tyr Uncertain significance Single submitter
- UFL1 p.His49Asp Uncertain significance Single submitter
- UFL1 p.His572Tyr Uncertain significance Single submitter
- UFL1 p.His703Arg Uncertain significance Single submitter
- UFL1 p.His71Arg Uncertain significance Single submitter
- UFL1 p.His71Tyr Uncertain significance Single submitter
- UFL1 p.His725Tyr Uncertain significance Single submitter
- UFL1 p.Ile165Thr Uncertain significance Single submitter
- UFL1 p.Leu267Ile Uncertain significance Single submitter
- UFL1 p.Leu296Trp Uncertain significance Single submitter
- UFL1 p.Leu329Pro Uncertain significance Single submitter
- UFL1 p.Leu401Gln Uncertain significance Single submitter
- UFL1 p.Leu407Ser Uncertain significance Single submitter
- UFL1 p.Leu514Phe Uncertain significance Single submitter
- UFL1 p.Leu514Val Uncertain significance Single submitter
- UFL1 p.Leu51Phe Uncertain significance Single submitter
- UFL1 p.Leu672Val Uncertain significance Single submitter
- UFL1 p.Leu90Arg Uncertain significance Single submitter
- UFL1 p.Lys102Arg Uncertain significance Single submitter
- UFL1 p.Lys38Arg Uncertain significance Single submitter
- UFL1 p.Lys415Thr Uncertain significance Single submitter
- UFL1 p.Lys471Gln Uncertain significance Single submitter
- UFL1 p.Lys538Arg Uncertain significance Single submitter
- UFL1 p.Lys571Arg Uncertain significance Single submitter
- UFL1 p.Met346Ile Uncertain significance Single submitter
- UFL1 p.Met558Val Uncertain significance Single submitter
- UFL1 p.Phe261Ser Uncertain significance Single submitter
- UFL1 p.Phe497Cys Uncertain significance Single submitter
- UFL1 p.Pro149Ser Uncertain significance Single submitter
- UFL1 p.Pro392Leu Uncertain significance Single submitter
- UFL1 p.Pro752Arg Uncertain significance Single submitter
- UFL1 p.Ser28Pro Uncertain significance Single submitter
- UFL1 p.Ser319Cys Uncertain significance Single submitter
- UFL1 p.Ser475Arg Uncertain significance Single submitter
- UFL1 p.Ser591Leu Uncertain significance Single submitter
- UFL1 p.Ser629Cys Uncertain significance Single submitter
- UFL1 p.Ser700Gly Uncertain significance Single submitter
- UFL1 p.Ser743Gly Uncertain significance Single submitter
- UFL1 p.Thr138Ser Uncertain significance Single submitter
- UFL1 p.Thr145Ile Uncertain significance Single submitter
- UFL1 p.Thr179Met Uncertain significance Single submitter
- UFL1 p.Thr526Ile Uncertain significance Single submitter
- UFL1 p.Thr531Met Uncertain significance Single submitter
- UFL1 p.Thr570Ile Uncertain significance Single submitter
- UFL1 p.Thr582Pro Uncertain significance Single submitter
- UFL1 p.Thr792Met Uncertain significance Single submitter
- UFL1 p.Tyr249Cys Uncertain significance Single submitter
- UFL1 p.Tyr249Phe Uncertain significance Single submitter
- UFL1 p.Tyr283Ser Uncertain significance Single submitter
- UFL1 p.Val183Ile Uncertain significance Single submitter
- UFL1 p.Val36Ile Uncertain significance Single submitter
- UFL1 p.Val393Ala Uncertain significance Single submitter
- UFL1 p.Val410Leu Uncertain significance Single submitter
- UFL1 p.Val729Ile Uncertain significance Single submitter
- UFL1 p.Val764Ala Uncertain significance Single submitter
- UFL1 p.Val77Leu Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- UFL1 p.Ala12Gly Uncertain significance Single submitter
- UFL1 p.Arg185Gly Uncertain significance Single submitter
- UFL1 p.Arg421Gln Uncertain significance Single submitter
- UFL1 p.Arg422Thr Uncertain significance Single submitter
- UFL1 p.Arg535Cys Uncertain significance Single submitter
- UFL1 p.Arg9Thr Uncertain significance Single submitter
- UFL1 p.Gln663Arg Uncertain significance Single submitter
- UFL1 p.His627Arg Uncertain significance Single submitter
- UFL1 p.Lys788Glu Uncertain significance Single submitter
- UFL1 p.Phe295Leu Uncertain significance Single submitter
- UFL1 p.Phe554Ser Uncertain significance Single submitter
- UFL1 p.Pro59Leu Uncertain significance Single submitter
- UFL1 p.Tyr119Phe Uncertain significance Single submitter
- UFL1 p.Val301Leu Uncertain significance Single submitter
All UFL1 variants
Benign 3
- p.Leu665Val Single submitter
- p.Ser499= Single submitter
- p.Ser499Leu Single submitter
Likely benign 1
- p.Met432Val Single submitter
Uncertain significance 117
- p.Pro705Arg Multiple submitters hereditary breast ovarian cancer syndrome ⚠
- p.Ala124Ser Single submitter ⚠
- p.Ala12Gly Single submitter ⚠
- p.Ala299Val Single submitter ⚠
- p.Ala353Ser Single submitter ⚠
- p.Ala648Val Single submitter ⚠
- p.Arg185Gly Single submitter ⚠
- p.Arg191Cys Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg30Gln Single submitter
- p.Arg30Leu Single submitter ⚠
- p.Arg377Cys Single submitter ⚠
- p.Arg377His Single submitter ⚠
- p.Arg421Gln Single submitter ⚠
- p.Arg422Thr Single submitter ⚠
- p.Arg433Lys Single submitter ⚠
- p.Arg533Gly Single submitter ⚠
- p.Arg535Cys Single submitter ⚠
- p.Arg9Thr Single submitter ⚠
- p.Asn226His Single submitter ⚠
- p.Asn631Asp Single submitter ⚠
- p.Asp270Glu Single submitter ⚠
- p.Asp650His Single submitter ⚠
- p.Asp723Gly Single submitter ⚠
- p.Cys300Tyr Single submitter ⚠
- p.Gln213Arg Single submitter ⚠
- p.Gln403His Single submitter ⚠
- p.Gln663Arg Single submitter ⚠
- p.Gln773His Single submitter ⚠
- p.Glu222Gly Single submitter ⚠
- p.Glu314Asp Single submitter ⚠
- p.Glu314Gly Single submitter ⚠
- p.Glu314Val Single submitter ⚠
- p.Glu336Asp Single submitter ⚠
- p.Glu46Asp Single submitter ⚠
- p.Glu515Lys Single submitter ⚠
- p.Glu618Gln Single submitter ⚠
- p.Glu636Asp Single submitter ⚠
- p.Glu636Lys Single submitter ⚠
- p.Glu647Gly Single submitter ⚠
- p.Glu69Lys Single submitter ⚠
- p.Glu6Ala Single submitter ⚠
- p.Glu7Gly Single submitter ⚠
- p.Gly135Ser Single submitter ⚠
- p.Gly175Glu Single submitter
- p.Gly228Arg Single submitter ⚠
- p.Gly320Arg Single submitter ⚠
- p.Gly452Glu Single submitter ⚠
- p.Gly532Val Single submitter ⚠
- p.Gly749Glu Single submitter ⚠
- p.His186Arg Single submitter
- p.His489Tyr Single submitter ⚠
- p.His49Asp Single submitter ⚠
- p.His572Tyr Single submitter ⚠
- p.His627Arg Single submitter ⚠
- p.His703Arg Single submitter ⚠
- p.His71Arg Single submitter ⚠
- p.His71Tyr Single submitter ⚠
- p.His725Tyr Single submitter ⚠
- p.Ile165Thr Single submitter ⚠
- p.Ile93Thr Single submitter
- p.Leu267Ile Single submitter ⚠
- p.Leu294Ser Single submitter
- p.Leu296Trp Single submitter ⚠
- p.Leu329Pro Single submitter ⚠
- p.Leu401Gln Single submitter ⚠
- p.Leu407Ser Single submitter ⚠
- p.Leu514Phe Single submitter ⚠
- p.Leu514Val Single submitter ⚠
- p.Leu51Phe Single submitter ⚠
- p.Leu672Val Single submitter ⚠
- p.Leu90Arg Single submitter ⚠
- p.Lys102Arg Single submitter ⚠
- p.Lys38Arg Single submitter ⚠
- p.Lys415Thr Single submitter ⚠
- p.Lys471Gln Single submitter ⚠
- p.Lys538Arg Single submitter ⚠
- p.Lys571Arg Single submitter ⚠
- p.Lys788Glu Single submitter ⚠
- p.Met346Ile Single submitter ⚠
- p.Met558Val Single submitter ⚠
- p.Phe261Ser Single submitter ⚠
- p.Phe295Leu Single submitter ⚠
- p.Phe368Cys Single submitter
- p.Phe497Cys Single submitter ⚠
- p.Phe554Ser Single submitter ⚠
- p.Pro149Ser Single submitter ⚠
- p.Pro392Leu Single submitter ⚠
- p.Pro59Leu Single submitter ⚠
- p.Pro752Arg Single submitter ⚠
- p.Ser28Pro Single submitter ⚠
- p.Ser319Cys Single submitter ⚠
- p.Ser475Arg Single submitter ⚠
- p.Ser591Leu Single submitter ⚠
- p.Ser629Cys Single submitter ⚠
- p.Ser700Gly Single submitter ⚠
- p.Ser743Gly Single submitter ⚠
- p.Thr138Ser Single submitter ⚠
- p.Thr145Ile Single submitter ⚠
- p.Thr179Met Single submitter ⚠
- p.Thr526Ile Single submitter ⚠
- p.Thr531Met Single submitter ⚠
- p.Thr570Ile Single submitter ⚠
- p.Thr582Pro Single submitter ⚠
- p.Thr792Met Single submitter ⚠
- p.Tyr119Phe Single submitter ⚠
- p.Tyr249Cys Single submitter ⚠
- p.Tyr249Phe Single submitter ⚠
- p.Tyr283Ser Single submitter ⚠
- p.Val183Ile Single submitter ⚠
- p.Val301Leu Single submitter ⚠
- p.Val36Ile Single submitter ⚠
- p.Val393Ala Single submitter ⚠
- p.Val410Leu Single submitter ⚠
- p.Val729Ile Single submitter ⚠
- p.Val764Ala Single submitter ⚠
- p.Val77Leu Single submitter ⚠