UGT1A3 — 39 ClinVar variants
All ClinVar germline UGT1A3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 29 flagged for review →
10 Likely benign · 29 Uncertain significance
Full UGT1A3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 29
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT1A3 p.Ala158Thr Uncertain significance Single submitter
- UGT1A3 p.Arg210Lys Uncertain significance Single submitter
- UGT1A3 p.Arg210Met Uncertain significance Single submitter
- UGT1A3 p.Arg91Gly Uncertain significance Single submitter
- UGT1A3 p.Asn142His Uncertain significance Single submitter
- UGT1A3 p.Asp181Glu Uncertain significance Single submitter
- UGT1A3 p.Glu135Gly Uncertain significance Single submitter
- UGT1A3 p.His92Arg Uncertain significance Single submitter
- UGT1A3 p.Ile223Val Uncertain significance Single submitter
- UGT1A3 p.Leu249Val Uncertain significance Single submitter
- UGT1A3 p.Leu77Val Uncertain significance Single submitter
- UGT1A3 p.Lys163Thr Uncertain significance Single submitter
- UGT1A3 p.Met116Val Uncertain significance Single submitter
- UGT1A3 p.Met208Thr Uncertain significance Single submitter
- UGT1A3 p.Met214Ile Uncertain significance Single submitter
- UGT1A3 p.Met44Lys Uncertain significance Single submitter
- UGT1A3 p.Met67Ile Uncertain significance Single submitter
- UGT1A3 p.Phe146Leu Uncertain significance Single submitter
- UGT1A3 p.Pro10Leu Uncertain significance Single submitter
- UGT1A3 p.Ser127Cys Uncertain significance Single submitter
- UGT1A3 p.Thr79Ser Uncertain significance Single submitter
- UGT1A3 p.Tyr100His Uncertain significance Single submitter
- UGT1A3 p.Tyr80Ser Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- UGT1A3 p.Arg284Gly Uncertain significance Single submitter
- UGT1A3 p.Ile276Thr Uncertain significance Single submitter
- UGT1A3 p.Met273Ile Uncertain significance Single submitter
- UGT1A3 p.Phe89Leu Uncertain significance Single submitter
- UGT1A3 p.Ser39Gly Uncertain significance Single submitter
- UGT1A3 p.Thr76Ile Uncertain significance Single submitter
All UGT1A3 variants
Likely benign 10
- p.Ala158Val Multiple submitters
- p.Arg49Gln Single submitter
- p.His92Leu Single submitter
- p.Ile248Leu Single submitter
- p.Ile248Val Single submitter
- p.Leu132= Single submitter
- p.Lys109Thr Single submitter
- p.Met208Leu Single submitter
- p.Pro268= Single submitter
- p.Ser113Thr Single submitter
Uncertain significance 29
- p.Ala158Thr Single submitter ⚠
- p.Arg210Lys Single submitter ⚠
- p.Arg210Met Single submitter ⚠
- p.Arg284Gly Single submitter ⚠
- p.Arg91Gly Single submitter ⚠
- p.Asn142His Single submitter ⚠
- p.Asp181Glu Single submitter ⚠
- p.Glu135Gly Single submitter ⚠
- p.His92Arg Single submitter ⚠
- p.Ile223Val Single submitter ⚠
- p.Ile276Thr Single submitter ⚠
- p.Leu249Val Single submitter ⚠
- p.Leu77Val Single submitter ⚠
- p.Lys163Thr Single submitter ⚠
- p.Met116Val Single submitter ⚠
- p.Met208Thr Single submitter ⚠
- p.Met214Ile Single submitter ⚠
- p.Met273Ile Single submitter ⚠
- p.Met44Lys Single submitter ⚠
- p.Met67Ile Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Phe89Leu Single submitter ⚠
- p.Pro10Leu Single submitter ⚠
- p.Ser127Cys Single submitter ⚠
- p.Ser39Gly Single submitter ⚠
- p.Thr76Ile Single submitter ⚠
- p.Thr79Ser Single submitter ⚠
- p.Tyr100His Single submitter ⚠
- p.Tyr80Ser Single submitter ⚠