UGT1A4 — 44 ClinVar variants
All ClinVar germline UGT1A4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
9 Likely benign · 35 Uncertain significance
Full UGT1A4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT1A4 p.Ala159Val Uncertain significance Single submitter
- UGT1A4 p.Ala229Ser Uncertain significance Single submitter
- UGT1A4 p.Ala53Gly Uncertain significance Single submitter
- UGT1A4 p.Ala53Ser Uncertain significance Single submitter
- UGT1A4 p.Arg112Gly Uncertain significance Single submitter
- UGT1A4 p.Arg139Thr Uncertain significance Single submitter
- UGT1A4 p.Arg91His Uncertain significance Single submitter
- UGT1A4 p.Cys187Tyr Uncertain significance Single submitter
- UGT1A4 p.Gln86Arg Uncertain significance Single submitter
- UGT1A4 p.Glu237Asp Uncertain significance Single submitter
- UGT1A4 p.Glu27Asp Uncertain significance Single submitter
- UGT1A4 p.Gly15Val Uncertain significance Single submitter
- UGT1A4 p.Gly4Glu Uncertain significance Single submitter
- UGT1A4 p.Gly4Val Uncertain significance Single submitter
- UGT1A4 p.Gly99Arg Uncertain significance Single submitter
- UGT1A4 p.His56Arg Uncertain significance Single submitter
- UGT1A4 p.Ile116Met Uncertain significance Single submitter
- UGT1A4 p.Leu5Pro Uncertain significance Single submitter
- UGT1A4 p.Phe146Ser Uncertain significance Single submitter
- UGT1A4 p.Phe227Leu Uncertain significance Single submitter
- UGT1A4 p.Phe257Tyr Uncertain significance Single submitter
- UGT1A4 p.Pro268Leu Uncertain significance Single submitter
- UGT1A4 p.Ser113Arg Uncertain significance Single submitter
- UGT1A4 p.Ser288Pro Uncertain significance Single submitter
- UGT1A4 p.Thr76Ser Uncertain significance Single submitter
- UGT1A4 p.Val120Ile Uncertain significance Single submitter
- UGT1A4 p.Val154Phe Uncertain significance Single submitter
- UGT1A4 p.Val211Phe Uncertain significance Single submitter
- UGT1A4 p.Val22Ala Uncertain significance Single submitter
- UGT1A4 p.Val92Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- UGT1A4 p.Glu50Asp Likely benign Single submitter
- UGT1A4 p.Leu18His Uncertain significance Single submitter
- UGT1A4 p.Phe171Ile Uncertain significance Single submitter
- UGT1A4 p.Phe89Ser Uncertain significance Single submitter
- UGT1A4 p.Pro230Ser Uncertain significance Single submitter
- UGT1A4 p.Val274Phe Uncertain significance Single submitter
All UGT1A4 variants
Likely benign 9
- p.Ala229= Single submitter
- p.Ala47Val Single submitter
- p.Arg11Gln Single submitter
- p.Glu50Asp Single submitter ⚠
- p.Ser233= Single submitter
- p.Thr14= Single submitter
- p.Tyr251His Single submitter
- p.Val249Leu Single submitter
- p.Leu475= No assertion criteria UGT1A4-related disorder
Uncertain significance 35
- p.Ala159Val Single submitter ⚠
- p.Ala229Ser Single submitter ⚠
- p.Ala53Gly Single submitter ⚠
- p.Ala53Ser Single submitter ⚠
- p.Arg112Gly Single submitter ⚠
- p.Arg139Thr Single submitter ⚠
- p.Arg91His Single submitter ⚠
- p.Cys187Tyr Single submitter ⚠
- p.Gln86Arg Single submitter ⚠
- p.Glu237Asp Single submitter ⚠
- p.Glu27Asp Single submitter ⚠
- p.Gly15Val Single submitter ⚠
- p.Gly4Glu Single submitter ⚠
- p.Gly4Val Single submitter ⚠
- p.Gly99Arg Single submitter ⚠
- p.His56Arg Single submitter ⚠
- p.Ile116Met Single submitter ⚠
- p.Leu18His Single submitter ⚠
- p.Leu5Pro Single submitter ⚠
- p.Phe146Ser Single submitter ⚠
- p.Phe171Ile Single submitter ⚠
- p.Phe227Leu Single submitter ⚠
- p.Phe257Tyr Single submitter ⚠
- p.Phe89Ser Single submitter ⚠
- p.Pro230Ser Single submitter ⚠
- p.Pro268Leu Single submitter ⚠
- p.Ser113Arg Single submitter ⚠
- p.Ser288Pro Single submitter ⚠
- p.Thr76Ser Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val154Phe Single submitter ⚠
- p.Val211Phe Single submitter ⚠
- p.Val22Ala Single submitter ⚠
- p.Val274Phe Single submitter ⚠
- p.Val92Ile Single submitter ⚠