UGT1A6 — 65 ClinVar variants
All ClinVar germline UGT1A6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
1 Conflicting · 6 Benign · 2 Likely benign · 56 Uncertain significance
Full UGT1A6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT1A6 p.Arg6Cys Uncertain significance Multiple submitters
- UGT1A6 p.Leu49Arg Uncertain significance Multiple submitters
- UGT1A6 p.Lys88Arg Uncertain significance Multiple submitters
- UGT1A6 p.Ala152Thr Uncertain significance Single submitter
- UGT1A6 p.Arg10Lys Uncertain significance Single submitter
- UGT1A6 p.Arg133Met Uncertain significance Single submitter
- UGT1A6 p.Arg184Gly Uncertain significance Single submitter
- UGT1A6 p.Arg208Gln Uncertain significance Single submitter
- UGT1A6 p.Arg265Gly Uncertain significance Single submitter
- UGT1A6 p.Asn125Asp Uncertain significance Single submitter
- UGT1A6 p.Asn137Asp Uncertain significance Single submitter
- UGT1A6 p.Asp187Glu Uncertain significance Single submitter
- UGT1A6 p.Asp44Asn Uncertain significance Single submitter
- UGT1A6 p.Asp44His Uncertain significance Single submitter
- UGT1A6 p.Gln127Glu Uncertain significance Single submitter
- UGT1A6 p.Glu69Gly Uncertain significance Single submitter
- UGT1A6 p.Gly173Ala Uncertain significance Single submitter
- UGT1A6 p.Gly173Ser Uncertain significance Single submitter
- UGT1A6 p.His98Arg Uncertain significance Single submitter
- UGT1A6 p.Ile124Asn Uncertain significance Single submitter
- UGT1A6 p.Ile244Asn Uncertain significance Single submitter
- UGT1A6 p.Ile277Met Uncertain significance Single submitter
- UGT1A6 p.Ile77Val Uncertain significance Single submitter
- UGT1A6 p.Leu216Phe Uncertain significance Single submitter
- UGT1A6 p.Leu221Ile Uncertain significance Single submitter
- UGT1A6 p.Leu67Val Uncertain significance Single submitter
- UGT1A6 p.Lys238Arg Uncertain significance Single submitter
- UGT1A6 p.Met116Ile Uncertain significance Single submitter
- UGT1A6 p.Met42Val Uncertain significance Single submitter
- UGT1A6 p.Pro108Ser Uncertain significance Single submitter
- UGT1A6 p.Pro166Ser Uncertain significance Single submitter
- UGT1A6 p.Pro175Ala Uncertain significance Single submitter
- UGT1A6 p.Ser177Cys Uncertain significance Single submitter
- UGT1A6 p.Ser185Asn Uncertain significance Single submitter
- UGT1A6 p.Trp21Arg Uncertain significance Single submitter
- UGT1A6 p.Trp253Arg Uncertain significance Single submitter
- UGT1A6 p.Tyr196Ser Uncertain significance Single submitter
- UGT1A6 p.Tyr247Cys Uncertain significance Single submitter
- UGT1A6 p.Tyr72His Uncertain significance Single submitter
- UGT1A6 p.Val267Ile Uncertain significance Single submitter
- UGT1A6 p.Val48Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- UGT1A6 c.861+35946G>C Uncertain significance Single submitter
- UGT1A6 p.Arg52Trp Uncertain significance Single submitter
- UGT1A6 p.Arg90Cys Uncertain significance Single submitter
- UGT1A6 p.Arg90Gly Uncertain significance Single submitter
- UGT1A6 p.Arg90His Uncertain significance Single submitter
- UGT1A6 p.Asp145His Uncertain significance Single submitter
- UGT1A6 p.Leu29Met Uncertain significance Single submitter
- UGT1A6 p.Lys76Asn Uncertain significance Single submitter
- UGT1A6 p.Pro186Leu Uncertain significance Single submitter
- UGT1A6 p.Val252Phe Uncertain significance Single submitter
- UGT1A6 p.Val31Met Uncertain significance Single submitter
All UGT1A6 variants
Conflicting classifications of pathogenicity 1
- c.862-10021T>G Single submitter UGT1A8-related condition
Benign 6
- p.Val209= Multiple submitters
- p.Arg184Ser Single submitter
- p.Asp35= Single submitter
- p.Leu105= Single submitter
- p.Ser7Ala Single submitter
- p.Thr181Ala Single submitter
Uncertain significance 56
- p.Arg6Cys Multiple submitters ⚠
- p.Leu49Arg Multiple submitters ⚠
- p.Lys88Arg Multiple submitters ⚠
- p.Pro186Ser Multiple submitters
- c.861+35946G>C Single submitter ⚠
- c.862-6813A>G Single submitter
- p.Ala152Thr Single submitter ⚠
- p.Arg10Lys Single submitter ⚠
- p.Arg133Met Single submitter ⚠
- p.Arg184Gly Single submitter ⚠
- p.Arg208Gln Single submitter ⚠
- p.Arg208Ter Single submitter
- p.Arg265Gly Single submitter ⚠
- p.Arg52Trp Single submitter ⚠
- p.Arg90Cys Single submitter ⚠
- p.Arg90Gly Single submitter ⚠
- p.Arg90His Single submitter ⚠
- p.Asn125Asp Single submitter ⚠
- p.Asn137Asp Single submitter ⚠
- p.Asp145His Single submitter ⚠
- p.Asp187Glu Single submitter ⚠
- p.Asp44Asn Single submitter ⚠
- p.Asp44His Single submitter ⚠
- p.Gln127Glu Single submitter ⚠
- p.Glu69Gly Single submitter ⚠
- p.Gly173Ala Single submitter ⚠
- p.Gly173Ser Single submitter ⚠
- p.His54fs Single submitter
- p.His98Arg Single submitter ⚠
- p.Ile124Asn Single submitter ⚠
- p.Ile244Asn Single submitter ⚠
- p.Ile277Met Single submitter ⚠
- p.Ile77Val Single submitter ⚠
- p.Leu216Phe Single submitter ⚠
- p.Leu221Ile Single submitter ⚠
- p.Leu29Met Single submitter ⚠
- p.Leu67Val Single submitter ⚠
- p.Lys238Arg Single submitter ⚠
- p.Lys76Asn Single submitter ⚠
- p.Met116Ile Single submitter ⚠
- p.Met42Val Single submitter ⚠
- p.Pro108Ser Single submitter ⚠
- p.Pro166Ser Single submitter ⚠
- p.Pro175Ala Single submitter ⚠
- p.Pro186Leu Single submitter ⚠
- p.Ser177Cys Single submitter ⚠
- p.Ser185Asn Single submitter ⚠
- p.Trp21Arg Single submitter ⚠
- p.Trp253Arg Single submitter ⚠
- p.Tyr196Ser Single submitter ⚠
- p.Tyr247Cys Single submitter ⚠
- p.Tyr72His Single submitter ⚠
- p.Val252Phe Single submitter ⚠
- p.Val267Ile Single submitter ⚠
- p.Val31Met Single submitter ⚠
- p.Val48Ile Single submitter ⚠