UGT1A7 — 58 ClinVar variants
All ClinVar germline UGT1A7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
1 Conflicting · 1 Benign · 11 Likely benign · 45 Uncertain significance
Full UGT1A7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 23
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT1A7 p.Phe224Ser Uncertain significance Multiple submitters
- UGT1A7 p.Ala152Asp Uncertain significance Single submitter
- UGT1A7 p.Ala185Thr Uncertain significance Single submitter
- UGT1A7 p.Ala25Ser Uncertain significance Single submitter
- UGT1A7 p.Arg68Ile Uncertain significance Single submitter
- UGT1A7 p.Asn226Asp Uncertain significance Single submitter
- UGT1A7 p.Asn276Ser Uncertain significance Single submitter
- UGT1A7 p.Cys141Ser Uncertain significance Single submitter
- UGT1A7 p.Glu135Asp Uncertain significance Single submitter
- UGT1A7 p.Glu215Gly Uncertain significance Single submitter
- UGT1A7 p.Gly35Glu Uncertain significance Single submitter
- UGT1A7 p.His278Leu Uncertain significance Single submitter
- UGT1A7 p.Ile156Thr Uncertain significance Single submitter
- UGT1A7 p.Leu193Ile Uncertain significance Single submitter
- UGT1A7 p.Lys159Arg Uncertain significance Single submitter
- UGT1A7 p.Lys159Glu Uncertain significance Single submitter
- UGT1A7 p.Met201Lys Uncertain significance Single submitter
- UGT1A7 p.Met212Ile Uncertain significance Single submitter
- UGT1A7 p.Phe173Cys Uncertain significance Single submitter
- UGT1A7 p.Ser104Gly Uncertain significance Single submitter
- UGT1A7 p.Trp6Cys Uncertain significance Single submitter
- UGT1A7 p.Tyr13His Uncertain significance Single submitter
- UGT1A7 p.Tyr189His Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- UGT1A7 p.Met41Ile Uncertain significance Multiple submitters
- UGT1A7 p.Ala23Asp Uncertain significance Single submitter
- UGT1A7 p.Ala25Val Uncertain significance Single submitter
- UGT1A7 p.Arg192Thr Uncertain significance Single submitter
- UGT1A7 p.Arg68Ser Uncertain significance Single submitter
- UGT1A7 p.Asn276Lys Uncertain significance Single submitter
- UGT1A7 p.Gly171Arg Uncertain significance Single submitter
- UGT1A7 p.Phe142Leu Uncertain significance Single submitter
- UGT1A7 p.Phe90Leu Uncertain significance Single submitter
- UGT1A7 p.Pro184Ser Uncertain significance Single submitter
- UGT1A7 p.Pro284His Uncertain significance Single submitter
- UGT1A7 p.Pro32Thr Uncertain significance Single submitter
- UGT1A7 p.Ser140Cys Uncertain significance Single submitter
All UGT1A7 variants
Conflicting classifications of pathogenicity 1
- p.Asp118Tyr Single submitter ⚠
Benign 1
- p.Arg131Lys Single submitter
Likely benign 11
- c.855+20G>A Single submitter
- p.Asn123His Single submitter
- p.Asn129Arg Single submitter
- p.Asp243= Single submitter
- p.Asp95Asn Single submitter
- p.Gln42Arg Single submitter
- p.Glu139Asp Single submitter
- p.Glu260Asp Single submitter
- p.Gly115Ser Single submitter
- p.Ile172Val Single submitter
- p.Pro221His Single submitter
Uncertain significance 45
- p.Asn268His Multiple submitters
- p.Met41Ile Multiple submitters ⚠
- p.Phe224Ser Multiple submitters ⚠
- p.Ala152Asp Single submitter ⚠
- p.Ala185Thr Single submitter ⚠
- p.Ala23Asp Single submitter ⚠
- p.Ala25Ser Single submitter ⚠
- p.Ala25Val Single submitter ⚠
- p.Arg192Thr Single submitter ⚠
- p.Arg254Ter Single submitter
- p.Arg68Ile Single submitter ⚠
- p.Arg68Ser Single submitter ⚠
- p.Asn226Asp Single submitter ⚠
- p.Asn276Lys Single submitter ⚠
- p.Asn276Ser Single submitter ⚠
- p.Cys141Ser Single submitter ⚠
- p.Glu135Asp Single submitter ⚠
- p.Glu215Gly Single submitter ⚠
- p.Gly171Arg Single submitter ⚠
- p.Gly274Ser Single submitter
- p.Gly35Glu Single submitter ⚠
- p.His278Leu Single submitter ⚠
- p.Ile156Thr Single submitter ⚠
- p.Ile275fs Single submitter
- p.Leu193Ile Single submitter ⚠
- p.Lys159Arg Single submitter ⚠
- p.Lys159Glu Single submitter ⚠
- p.Met201Lys Single submitter ⚠
- p.Met212Ile Single submitter ⚠
- p.Phe142Leu Single submitter ⚠
- p.Phe168fs Single submitter
- p.Phe173Cys Single submitter ⚠
- p.Phe90Leu Single submitter ⚠
- p.Pro184Ser Single submitter ⚠
- p.Pro284His Single submitter ⚠
- p.Pro32Thr Single submitter ⚠
- p.Ser104Gly Single submitter ⚠
- p.Ser122Pro Single submitter
- p.Ser140Cys Single submitter ⚠
- p.Trp64Ter Single submitter
- p.Trp6Cys Single submitter ⚠
- p.Tyr13His Single submitter ⚠
- p.Tyr189His Single submitter ⚠
- p.Tyr81Ter Single submitter
- p.Val58Phe Single submitter