UGT1A8 — 68 ClinVar variants
All ClinVar germline UGT1A8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Conflicting · 18 Benign · 10 Likely benign · 39 Uncertain significance
Full UGT1A8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 30
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT1A8 p.Arg88Gln Uncertain significance Multiple submitters
- UGT1A8 c.855+63716A>G Uncertain significance Single submitter
- UGT1A8 c.855+64228A>G Uncertain significance Single submitter
- UGT1A8 p.Ala241Thr Uncertain significance Single submitter
- UGT1A8 p.Ala2Gly Uncertain significance Single submitter
- UGT1A8 p.Ala94Thr Uncertain significance Single submitter
- UGT1A8 p.Asn114Ser Uncertain significance Single submitter
- UGT1A8 p.Asn118Ser Uncertain significance Single submitter
- UGT1A8 p.Asp151Asn Uncertain significance Single submitter
- UGT1A8 p.Asp260Glu Uncertain significance Single submitter
- UGT1A8 p.Asp34Val Uncertain significance Single submitter
- UGT1A8 p.Asp87Val Uncertain significance Single submitter
- UGT1A8 p.Cys277Ser Uncertain significance Single submitter
- UGT1A8 p.Gly171Ala Uncertain significance Single submitter
- UGT1A8 p.His278Arg Uncertain significance Single submitter
- UGT1A8 p.Leu252Phe Uncertain significance Single submitter
- UGT1A8 p.Leu48Phe Uncertain significance Single submitter
- UGT1A8 p.Lys159Arg Uncertain significance Single submitter
- UGT1A8 p.Phe120Ser Uncertain significance Single submitter
- UGT1A8 p.Phe501Tyr Uncertain significance Single submitter
- UGT1A8 p.Pro149His Uncertain significance Single submitter
- UGT1A8 p.Pro149Leu Uncertain significance Single submitter
- UGT1A8 p.Pro164Leu Uncertain significance Single submitter
- UGT1A8 p.Ser113Phe Uncertain significance Single submitter
- UGT1A8 p.Ser113Tyr Uncertain significance Single submitter
- UGT1A8 p.Thr79Ala Uncertain significance Single submitter
- UGT1A8 p.Thr82Ala Uncertain significance Single submitter
- UGT1A8 p.Trp38Leu Uncertain significance Single submitter
- UGT1A8 p.Tyr176His Uncertain significance Single submitter
- UGT1A8 p.Val157Asp Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- UGT1A8 p.Arg170Gly Uncertain significance Single submitter
- UGT1A8 p.Arg192Ser Uncertain significance Single submitter
- UGT1A8 p.Arg51Gly Uncertain significance Single submitter
- UGT1A8 p.Arg88Trp Uncertain significance Single submitter
- UGT1A8 p.Glu205Lys Uncertain significance Single submitter
- UGT1A8 p.Gly274Ala Uncertain significance Single submitter
- UGT1A8 p.Trp98Cys Uncertain significance Single submitter
- UGT1A8 p.Tyr77Cys Uncertain significance Single submitter
All UGT1A8 variants
Conflicting classifications of pathogenicity 1
- c.855+63319T>G Single submitter
Benign 18
- c.855+63408C>A Multiple submitters
- c.855+63762T>G Multiple submitters
- c.855+63766C>A Multiple submitters
- c.855+63767G>A Multiple submitters
- c.855+63997T>C Multiple submitters
- c.855+64131G>A Multiple submitters
- c.856-53268G>C Multiple submitters
- c.1076-79G>A Single submitter
- c.1296-229A>C Single submitter
- c.855+51220C>T Single submitter
- c.855+63270T>G Single submitter
- c.856-113C>T Single submitter
- c.856-5794C>T Single submitter
- c.856-6852T>C Single submitter
- c.987+307A>G Single submitter
- c.988-100_988-99dup Single submitter
- c.988-37T>C Single submitter
- c.988-83C>T Single submitter
Likely benign 10
- c.855+63761A>G Multiple submitters
- c.1075+20T>G Single submitter
- c.856-73523C>T Single submitter
- p.Phe93= Single submitter
- p.Pro11Leu Single submitter
- p.Ser8Gly Single submitter
- p.Thr255= Single submitter
- p.Tyr433= Single submitter
- p.Val102Ile Single submitter
- p.Val30= Single submitter
Uncertain significance 39
- p.Arg88Gln Multiple submitters ⚠
- c.855+63716A>G Single submitter ⚠
- c.855+64228A>G Single submitter ⚠
- p.Ala241Thr Single submitter ⚠
- p.Ala2Gly Single submitter ⚠
- p.Ala94Thr Single submitter ⚠
- p.Arg170Gly Single submitter ⚠
- p.Arg192Ser Single submitter ⚠
- p.Arg51Gly Single submitter ⚠
- p.Arg88Trp Single submitter ⚠
- p.Asn114Ser Single submitter ⚠
- p.Asn118Ser Single submitter ⚠
- p.Asp151Asn Single submitter ⚠
- p.Asp260Glu Single submitter ⚠
- p.Asp34Val Single submitter ⚠
- p.Asp87Val Single submitter ⚠
- p.Cys277Ser Single submitter ⚠
- p.Glu205Lys Single submitter ⚠
- p.Gly171Ala Single submitter ⚠
- p.Gly274Ala Single submitter ⚠
- p.His278Arg Single submitter ⚠
- p.Leu252Phe Single submitter ⚠
- p.Leu48Phe Single submitter ⚠
- p.Lys159Arg Single submitter ⚠
- p.Phe120Ser Single submitter ⚠
- p.Phe501Tyr Single submitter ⚠
- p.Pro149His Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro164Leu Single submitter ⚠
- p.Ser113Phe Single submitter ⚠
- p.Ser113Tyr Single submitter ⚠
- p.Thr79Ala Single submitter ⚠
- p.Thr82Ala Single submitter ⚠
- p.Trp38Leu Single submitter ⚠
- p.Trp98Cys Single submitter ⚠
- p.Tyr176His Single submitter ⚠
- p.Tyr77Cys Single submitter ⚠
- p.Val157Asp Single submitter ⚠
- p.Val166Ala Single submitter