UGT1A9 — 47 ClinVar variants
All ClinVar germline UGT1A9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
2 Benign · 1 Benign/Likely benign · 8 Likely benign · 36 Uncertain significance
Full UGT1A9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT1A9 p.Ala227Val Uncertain significance Single submitter
- UGT1A9 p.Ala474Ser Uncertain significance Single submitter
- UGT1A9 p.Ala92Pro Uncertain significance Single submitter
- UGT1A9 p.Arg206Gly Uncertain significance Single submitter
- UGT1A9 p.Arg222Cys Uncertain significance Single submitter
- UGT1A9 p.Asp148Tyr Uncertain significance Single submitter
- UGT1A9 p.Asp34Gly Uncertain significance Single submitter
- UGT1A9 p.Glu24Lys Uncertain significance Single submitter
- UGT1A9 p.Gly171Val Uncertain significance Single submitter
- UGT1A9 p.Gly274Arg Uncertain significance Single submitter
- UGT1A9 p.His175Arg Uncertain significance Single submitter
- UGT1A9 p.His221Arg Uncertain significance Single submitter
- UGT1A9 p.Ile250Met Uncertain significance Single submitter
- UGT1A9 p.Leu10Ile Uncertain significance Single submitter
- UGT1A9 p.Leu133Ile Uncertain significance Single submitter
- UGT1A9 p.Leu155Val Uncertain significance Single submitter
- UGT1A9 p.Leu187Phe Uncertain significance Single submitter
- UGT1A9 p.Lys75Arg Uncertain significance Single submitter
- UGT1A9 p.Phe120Ile Uncertain significance Single submitter
- UGT1A9 p.Pro238Ser Uncertain significance Single submitter
- UGT1A9 p.Pro282Ser Uncertain significance Single submitter
- UGT1A9 p.Ser126Asn Uncertain significance Single submitter
- UGT1A9 p.Ser43Leu Uncertain significance Single submitter
- UGT1A9 p.Thr255Met Uncertain significance Single submitter
- UGT1A9 p.Val62Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- UGT1A9 p.Glu54Lys Uncertain significance Single submitter
- UGT1A9 p.Phe224Leu Uncertain significance Single submitter
- UGT1A9 p.Pro282Leu Uncertain significance Single submitter
- UGT1A9 p.Pro284Arg Uncertain significance Single submitter
- UGT1A9 p.Thr202Ala Uncertain significance Single submitter
- UGT1A9 p.Thr73Ala Uncertain significance Single submitter
- UGT1A9 p.Val258Ala Uncertain significance Single submitter
All UGT1A9 variants
Benign 2
- p.Met33Thr Single submitter
- p.Leu66= No assertion criteria UGT1A9-related disorder
Benign/Likely benign 1
- p.Lys75= Multiple submitters
Likely benign 8
- p.Ala100Thr Single submitter
- p.Tyr481= Single submitter
- p.Ala144= No assertion criteria UGT1A9-related disorder
- p.Cys3Tyr No assertion criteria UGT1A9-related disorder
- p.Glu139= No assertion criteria UGT1A9-related disorder
- p.Ser141= No assertion criteria UGT1A9-related disorder
- p.Ser306= No assertion criteria UGT1A9-related disorder
- p.Val167Ala No assertion criteria UGT1A9-related disorder
Uncertain significance 36
- c.855+45828G>A Single submitter
- p.Ala227Val Single submitter ⚠
- p.Ala474Ser Single submitter ⚠
- p.Ala92Pro Single submitter ⚠
- p.Arg206Gly Single submitter ⚠
- p.Arg222Cys Single submitter ⚠
- p.Asp130His Single submitter
- p.Asp143Glu Single submitter
- p.Asp148Tyr Single submitter ⚠
- p.Asp34Gly Single submitter ⚠
- p.Glu24Lys Single submitter ⚠
- p.Glu54Lys Single submitter ⚠
- p.Gly171Val Single submitter ⚠
- p.Gly274Arg Single submitter ⚠
- p.His175Arg Single submitter ⚠
- p.His221Arg Single submitter ⚠
- p.Ile250Met Single submitter ⚠
- p.Leu10Ile Single submitter ⚠
- p.Leu133Ile Single submitter ⚠
- p.Leu155Val Single submitter ⚠
- p.Leu187Phe Single submitter ⚠
- p.Lys75Arg Single submitter ⚠
- p.Phe120Ile Single submitter ⚠
- p.Phe224Leu Single submitter ⚠
- p.Phe257Val Single submitter
- p.Pro238Ser Single submitter ⚠
- p.Pro282Leu Single submitter ⚠
- p.Pro282Ser Single submitter ⚠
- p.Pro284Arg Single submitter ⚠
- p.Ser126Asn Single submitter ⚠
- p.Ser43Leu Single submitter ⚠
- p.Thr202Ala Single submitter ⚠
- p.Thr255Met Single submitter ⚠
- p.Thr73Ala Single submitter ⚠
- p.Val258Ala Single submitter ⚠
- p.Val62Ala Single submitter ⚠