UGT2B7 — 57 ClinVar variants
All ClinVar germline UGT2B7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 3 Likely benign · 53 Uncertain significance
Full UGT2B7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT2B7 p.Ala370Asp Uncertain significance Single submitter
- UGT2B7 p.Ala383Ser Uncertain significance Single submitter
- UGT2B7 p.Ala60Ser Uncertain significance Single submitter
- UGT2B7 p.Asn315Ser Uncertain significance Single submitter
- UGT2B7 p.Asp345Asn Uncertain significance Single submitter
- UGT2B7 p.Asp345Glu Uncertain significance Single submitter
- UGT2B7 p.Asp435Glu Uncertain significance Single submitter
- UGT2B7 p.Gln13Lys Uncertain significance Single submitter
- UGT2B7 p.Gln48Leu Uncertain significance Single submitter
- UGT2B7 p.Glu301Lys Uncertain significance Single submitter
- UGT2B7 p.Gly387Glu Uncertain significance Single submitter
- UGT2B7 p.Ile94Ser Uncertain significance Single submitter
- UGT2B7 p.Leu347Ser Uncertain significance Single submitter
- UGT2B7 p.Leu395Phe Uncertain significance Single submitter
- UGT2B7 p.Leu425Ser Uncertain significance Single submitter
- UGT2B7 p.Leu56Val Uncertain significance Single submitter
- UGT2B7 p.Leu63Ile Uncertain significance Single submitter
- UGT2B7 p.Leu86Met Uncertain significance Single submitter
- UGT2B7 p.Lys430Gln Uncertain significance Single submitter
- UGT2B7 p.Met208Thr Uncertain significance Single submitter
- UGT2B7 p.Met229Thr Uncertain significance Single submitter
- UGT2B7 p.Met292Ile Uncertain significance Single submitter
- UGT2B7 p.Met420Ile Uncertain significance Single submitter
- UGT2B7 p.Met420Val Uncertain significance Single submitter
- UGT2B7 p.Ser110Pro Uncertain significance Single submitter
- UGT2B7 p.Ser446Leu Uncertain significance Single submitter
- UGT2B7 p.Ser80Thr Uncertain significance Single submitter
- UGT2B7 p.Thr6Ser Uncertain significance Single submitter
- UGT2B7 p.Val169Leu Uncertain significance Single submitter
- UGT2B7 p.Val194Ile Uncertain significance Single submitter
- UGT2B7 p.Val3Met Uncertain significance Single submitter
- UGT2B7 p.Val415Glu Uncertain significance Single submitter
- UGT2B7 p.Val442Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- UGT2B7 p.Ala480Pro Uncertain significance Single submitter
- UGT2B7 p.Ala57Pro Uncertain significance Single submitter
- UGT2B7 p.Asn402Ser Uncertain significance Single submitter
- UGT2B7 p.Asp203Gly Uncertain significance Single submitter
- UGT2B7 p.Asp228Val Uncertain significance Single submitter
- UGT2B7 p.Cys156Arg Uncertain significance Single submitter
- UGT2B7 p.Glu32Ala Uncertain significance Single submitter
- UGT2B7 p.Ile357Thr Uncertain significance Single submitter
- UGT2B7 p.Lys182Asn Uncertain significance Single submitter
- UGT2B7 p.Lys430Glu Uncertain significance Single submitter
- UGT2B7 p.Met312Val Uncertain significance Single submitter
- UGT2B7 p.Ser422Asn Uncertain significance Single submitter
- UGT2B7 p.Ser422Thr Uncertain significance Single submitter
- UGT2B7 p.Tyr385Cys Uncertain significance Single submitter
- UGT2B7 p.Tyr438Cys Uncertain significance Single submitter
All UGT2B7 variants
Benign 1
- p.Tyr354= Multiple submitters
Likely benign 3
- p.Gln92= Single submitter
- p.Leu46Pro Single submitter
- p.Val304Ile Single submitter
Uncertain significance 53
- p.Ala370Asp Single submitter ⚠
- p.Ala383Ser Single submitter ⚠
- p.Ala383Thr Single submitter
- p.Ala412Thr Single submitter
- p.Ala480Pro Single submitter ⚠
- p.Ala57Pro Single submitter ⚠
- p.Ala60Ser Single submitter ⚠
- p.Arg49Gly Single submitter
- p.Asn315Ser Single submitter ⚠
- p.Asn402Ser Single submitter ⚠
- p.Asp203Gly Single submitter ⚠
- p.Asp228Val Single submitter ⚠
- p.Asp345Asn Single submitter ⚠
- p.Asp345Glu Single submitter ⚠
- p.Asp435Glu Single submitter ⚠
- p.Cys156Arg Single submitter ⚠
- p.Gln13Lys Single submitter ⚠
- p.Gln48Leu Single submitter ⚠
- p.Glu301Lys Single submitter ⚠
- p.Glu32Ala Single submitter ⚠
- p.Gly387Glu Single submitter ⚠
- p.Ile357Thr Single submitter ⚠
- p.Ile94Ser Single submitter ⚠
- p.Leu347Ser Single submitter ⚠
- p.Leu395Phe Single submitter ⚠
- p.Leu425Ser Single submitter ⚠
- p.Leu56Val Single submitter ⚠
- p.Leu63Ile Single submitter ⚠
- p.Leu86Met Single submitter ⚠
- p.Lys182Asn Single submitter ⚠
- p.Lys430Gln Single submitter ⚠
- p.Lys430Glu Single submitter ⚠
- p.Met208Thr Single submitter ⚠
- p.Met229Thr Single submitter ⚠
- p.Met292Ile Single submitter ⚠
- p.Met312Val Single submitter ⚠
- p.Met420Ile Single submitter ⚠
- p.Met420Val Single submitter ⚠
- p.Ser110Pro Single submitter ⚠
- p.Ser422Asn Single submitter ⚠
- p.Ser422Thr Single submitter ⚠
- p.Ser446Leu Single submitter ⚠
- p.Ser80Thr Single submitter ⚠
- p.Thr6Ser Single submitter ⚠
- p.Tyr385Cys Single submitter ⚠
- p.Tyr438Cys Single submitter ⚠
- p.Val169Leu Single submitter ⚠
- p.Val194Ile Single submitter ⚠
- p.Val239Asp Single submitter
- p.Val313Gly Single submitter
- p.Val3Met Single submitter ⚠
- p.Val415Glu Single submitter ⚠
- p.Val442Ile Single submitter ⚠