UGT8 — 58 ClinVar variants
All ClinVar germline UGT8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
1 Conflicting · 3 Benign · 9 Likely benign · 45 Uncertain significance
Full UGT8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UGT8 p.Ala122Asp Uncertain significance Single submitter
- UGT8 p.Ala305Ser Uncertain significance Single submitter
- UGT8 p.Arg72His Uncertain significance Single submitter
- UGT8 p.Asn418Ser Uncertain significance Single submitter
- UGT8 p.Asp186Glu Uncertain significance Single submitter
- UGT8 p.Gln424His Uncertain significance Single submitter
- UGT8 p.Glu408Val Uncertain significance Single submitter
- UGT8 p.Glu47Gln Uncertain significance Single submitter
- UGT8 p.Gly49Cys Uncertain significance Single submitter
- UGT8 p.His121Tyr Uncertain significance Single submitter
- UGT8 p.His235Leu Uncertain significance Single submitter
- UGT8 p.His512Arg Uncertain significance Single submitter
- UGT8 p.Ile23Val Uncertain significance Single submitter
- UGT8 p.Ile368Val Uncertain significance Single submitter
- UGT8 p.Ile445Met Uncertain significance Single submitter
- UGT8 p.Ile534Ser Uncertain significance Single submitter
- UGT8 p.Leu107Val Uncertain significance Single submitter
- UGT8 p.Leu201Phe Uncertain significance Single submitter
- UGT8 p.Leu409Phe Uncertain significance Single submitter
- UGT8 p.Lys228Met Uncertain significance Single submitter
- UGT8 p.Met35Val Uncertain significance Single submitter
- UGT8 p.Phe132Leu Uncertain significance Single submitter
- UGT8 p.Pro271Ser Uncertain significance Single submitter
- UGT8 p.Pro64Ser Uncertain significance Single submitter
- UGT8 p.Ser363Gly Uncertain significance Single submitter
- UGT8 p.Ser43Leu Uncertain significance Single submitter
- UGT8 p.Ser493Phe Uncertain significance Single submitter
- UGT8 p.Ser513Gly Uncertain significance Single submitter
- UGT8 p.Thr386Ala Uncertain significance Single submitter
- UGT8 p.Thr80Ile Uncertain significance Single submitter
- UGT8 p.Trp494Gly Uncertain significance Single submitter
- UGT8 p.Trp507Leu Uncertain significance Single submitter
- UGT8 p.Val146Met Uncertain significance Single submitter
- UGT8 p.Val258Ile Uncertain significance Single submitter
- UGT8 p.Val26Leu Uncertain significance Single submitter
- UGT8 p.Val515Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- UGT8 p.Arg461Cys Uncertain significance Single submitter
- UGT8 p.Arg60Gly Uncertain significance Single submitter
- UGT8 p.Asn455Ser Conflicting Single submitter
- UGT8 p.Lys195Glu Uncertain significance Single submitter
- UGT8 p.Phe323Leu Uncertain significance Single submitter
- UGT8 p.Ser421Cys Uncertain significance Single submitter
All UGT8 variants
Conflicting classifications of pathogenicity 1
- p.Asn455Ser Single submitter ⚠
Likely benign 9
- p.Gly152Arg Multiple submitters
- p.Ala18Val Single submitter
- p.Leu205= Single submitter
- p.Pro326Thr Single submitter
- p.Pro420= Single submitter
- p.Pro6= Single submitter
- p.Thr335= Single submitter
- p.Tyr446Cys Single submitter
- p.Val414= Single submitter
Uncertain significance 45
- p.Ala122Asp Single submitter ⚠
- p.Ala305Ser Single submitter ⚠
- p.Arg461Cys Single submitter ⚠
- p.Arg60Gly Single submitter ⚠
- p.Arg72His Single submitter ⚠
- p.Arg72Ser Single submitter
- p.Asn418Ser Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Gln424His Single submitter ⚠
- p.Glu408Val Single submitter ⚠
- p.Glu47Gln Single submitter ⚠
- p.Gly49Cys Single submitter ⚠
- p.His121Tyr Single submitter ⚠
- p.His235Leu Single submitter ⚠
- p.His512Arg Single submitter ⚠
- p.Ile23Val Single submitter ⚠
- p.Ile368Val Single submitter ⚠
- p.Ile445Met Single submitter ⚠
- p.Ile467Asn Single submitter
- p.Ile534Ser Single submitter ⚠
- p.Leu107Val Single submitter ⚠
- p.Leu201Phe Single submitter ⚠
- p.Leu409Phe Single submitter ⚠
- p.Lys195Glu Single submitter ⚠
- p.Lys228Met Single submitter ⚠
- p.Met35Val Single submitter ⚠
- p.Phe132Leu Single submitter ⚠
- p.Phe323Leu Single submitter ⚠
- p.Pro271Ser Single submitter ⚠
- p.Pro64Ser Single submitter ⚠
- p.Ser363Gly Single submitter ⚠
- p.Ser421Cys Single submitter ⚠
- p.Ser43Leu Single submitter ⚠
- p.Ser493Phe Single submitter ⚠
- p.Ser513Gly Single submitter ⚠
- p.Thr386Ala Single submitter ⚠
- p.Thr80Ile Single submitter ⚠
- p.Trp494Gly Single submitter ⚠
- p.Trp507Leu Single submitter ⚠
- p.Val146Met Single submitter ⚠
- p.Val258Ile Single submitter ⚠
- p.Val26Leu Single submitter ⚠
- p.Val26Met Single submitter
- p.Val390Leu Single submitter
- p.Val515Ile Single submitter ⚠