ULK2 — 147 ClinVar variants

All ClinVar germline ULK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 129 flagged for review →

1 Likely pathogenic · 5 Benign · 8 Likely benign · 133 Uncertain significance

Full ULK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 129

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

ULK2 p.His578Arg Likely pathogenic Single submitter
Abnormal brain morphology

Predictors lean, ClinVar uncertain 110

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 18

The independent predictors disagree with each other — read with care.

All ULK2 variants

Likely pathogenic 1

p.His578Arg Single submitter Abnormal brain morphology ⚠

Benign 5

p.Arg881Gln Multiple submitters
p.Gly5= Multiple submitters
p.Lys539= Multiple submitters
p.Tyr795= Multiple submitters
p.Gly556= Single submitter

Likely benign 8

p.Ala99Val Single submitter
p.Arg666= Single submitter
p.Asp500Ala Single submitter
p.Gln676= Single submitter
p.Met286Val Single submitter
p.Pro449Leu Single submitter
p.Ser522Leu Single submitter
p.Ser780= Single submitter

Uncertain significance 133

p.Ala1034Thr Single submitter ⚠
p.Ala264Glu Single submitter ⚠
p.Ala264Val Single submitter ⚠
p.Ala421Thr Single submitter ⚠
p.Ala529Thr Single submitter ⚠
p.Ala705Thr Single submitter ⚠
p.Ala896Val Single submitter ⚠
p.Ala904Thr Single submitter ⚠
p.Arg144Cys Single submitter ⚠
p.Arg144His Single submitter ⚠
p.Arg303His Single submitter ⚠
p.Arg412His Single submitter ⚠
p.Arg412Leu Single submitter ⚠
p.Arg448Gln Single submitter ⚠
p.Arg465Gln Single submitter ⚠
p.Arg567Gln Single submitter ⚠
p.Arg584Trp Single submitter ⚠
p.Arg625His Single submitter ⚠
p.Arg655Gln Single submitter ⚠
p.Arg684Gln Single submitter ⚠
p.Arg696Gln Single submitter ⚠
p.Arg747Lys Single submitter ⚠
p.Arg881Trp Single submitter ⚠
p.Asn330Lys Single submitter
p.Asn426Asp Single submitter ⚠
p.Asn42His Single submitter ⚠
p.Asn618Lys Single submitter ⚠
p.Asp954Tyr Single submitter ⚠
p.Cys551Gly Single submitter ⚠
p.Cys645Tyr Single submitter ⚠
p.Gln389Glu Single submitter ⚠
p.Gln415Arg Single submitter ⚠
p.Glu1013Ala Single submitter ⚠
p.Glu397Lys Single submitter ⚠
p.Glu652Lys Single submitter ⚠
p.Glu657Lys Single submitter ⚠
p.Glu816Asp Single submitter ⚠
p.Glu838Lys Single submitter ⚠
p.Glu955Ala Single submitter ⚠
p.Glu971Ala Single submitter ⚠
p.Gly18Glu Single submitter ⚠
p.Gly297Asp Single submitter ⚠
p.Gly470Ala Single submitter ⚠
p.Gly470Glu Single submitter ⚠
p.Gly498Asp Single submitter ⚠
p.Gly707Ser Single submitter ⚠
p.Gly757Arg Single submitter ⚠
p.His495Arg Single submitter ⚠
p.His741Gln Single submitter ⚠
p.Ile121Thr Single submitter ⚠
p.Ile41Val Single submitter ⚠
p.Ile51Thr Single submitter ⚠
p.Ile682Val Single submitter ⚠
p.Ile806Val Single submitter ⚠
p.Ile872Leu Single submitter ⚠
p.Leu1029Phe Single submitter ⚠
p.Leu14Phe Single submitter ⚠
p.Leu251Met Single submitter ⚠
p.Leu326Phe Single submitter ⚠
p.Leu60Ser Single submitter ⚠
p.Leu63Phe Single submitter ⚠
p.Leu646Arg Single submitter ⚠
p.Leu895Ile Single submitter
p.Leu899Val Single submitter ⚠
p.Lys257Asn Single submitter ⚠
p.Lys278Ile Single submitter
p.Lys877Asn Single submitter ⚠
p.Lys907Glu Single submitter ⚠
p.Lys963Arg Single submitter ⚠
p.Met187Val Single submitter ⚠
p.Met233Ile Single submitter ⚠
p.Met368Leu Single submitter ⚠
p.Met444Val Single submitter ⚠
p.Met835Val Single submitter ⚠
p.Met846Ile Single submitter ⚠
p.Pro219Leu Single submitter ⚠
p.Pro283Ala Single submitter ⚠
p.Pro311Ser Single submitter ⚠
p.Pro324Ala Single submitter ⚠
p.Pro329Ser Single submitter ⚠
p.Pro449Ser Single submitter ⚠
p.Pro474Ala Single submitter ⚠
p.Pro479Leu Single submitter ⚠
p.Pro737Ser Single submitter ⚠
p.Pro772Leu Single submitter ⚠
p.Pro800Leu Single submitter ⚠
p.Ser1027Leu Single submitter ⚠
p.Ser1032Thr Single submitter ⚠
p.Ser104Gly Single submitter ⚠
p.Ser148Asn Single submitter ⚠
p.Ser188Cys Single submitter ⚠
p.Ser309Cys Single submitter ⚠
p.Ser338Phe Single submitter ⚠
p.Ser396Arg Single submitter ⚠
p.Ser419Pro Single submitter ⚠
p.Ser422Thr Single submitter ⚠
p.Ser439Phe Single submitter ⚠
p.Ser560Asn Single submitter ⚠
p.Ser585Arg Single submitter ⚠
p.Ser616Cys Single submitter ⚠
p.Ser633Leu Single submitter ⚠
p.Ser674Ter Single submitter
p.Ser719Cys Single submitter ⚠
p.Ser754Gly Single submitter ⚠
p.Ser801Gly Single submitter ⚠
p.Ser859Phe Single submitter ⚠
p.Ser947Phe Single submitter ⚠
p.Ser975Cys Single submitter ⚠
p.Thr107Met Single submitter ⚠
p.Thr391Ile Single submitter ⚠
p.Thr441Ser Single submitter ⚠
p.Thr624Ile Single submitter ⚠
p.Thr694Arg Single submitter ⚠
p.Thr694Ile Single submitter ⚠
p.Thr824Pro Single submitter ⚠
p.Thr837Ala Single submitter ⚠
p.Thr915Ala Single submitter ⚠
p.Thr985Ala Single submitter ⚠
p.Trp879Gly Single submitter ⚠
p.Tyr331Cys Single submitter ⚠
p.Tyr475Phe Single submitter ⚠
p.Tyr888His Single submitter
p.Tyr990Asp Single submitter ⚠
p.Val392Ala Single submitter ⚠
p.Val427Ala Single submitter ⚠
p.Val550Met Single submitter ⚠
p.Val623Ile Single submitter ⚠
p.Val648Leu Single submitter ⚠
p.Val668Ile Single submitter ⚠
p.Val709Gly Single submitter ⚠
p.Val767Met Single submitter ⚠
p.Val769Leu Single submitter ⚠
p.Ala172Ser No assertion criteria prostate cancer ⚠