ULK3 — 89 ClinVar variants
All ClinVar germline ULK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
4 Benign · 6 Likely benign · 79 Uncertain significance
Full ULK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 57
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ULK3 p.Ala114Val Uncertain significance Single submitter
- ULK3 p.Ala192Thr Uncertain significance Single submitter
- ULK3 p.Ala26Thr Uncertain significance Single submitter
- ULK3 p.Ala286Val Uncertain significance Single submitter
- ULK3 p.Ala303Thr Uncertain significance Single submitter
- ULK3 p.Ala378Thr Uncertain significance Single submitter
- ULK3 p.Arg115Cys Uncertain significance Single submitter
- ULK3 p.Arg226His Uncertain significance Single submitter
- ULK3 p.Arg236Gln Uncertain significance Single submitter
- ULK3 p.Arg244Gln Uncertain significance Single submitter
- ULK3 p.Arg257His Uncertain significance Single submitter
- ULK3 p.Arg258Cys Uncertain significance Single submitter
- ULK3 p.Arg340Trp Uncertain significance Single submitter
- ULK3 p.Arg371Trp Uncertain significance Single submitter
- ULK3 p.Arg38Cys Uncertain significance Single submitter
- ULK3 p.Arg423Gln Uncertain significance Single submitter
- ULK3 p.Arg466Cys Uncertain significance Single submitter
- ULK3 p.Asn132His Uncertain significance Single submitter
- ULK3 p.Asn352His Uncertain significance Single submitter
- ULK3 p.Asn86Ser Uncertain significance Single submitter
- ULK3 p.Asp83Tyr Uncertain significance Single submitter
- ULK3 p.Gln162Pro Uncertain significance Single submitter
- ULK3 p.Gln262Arg Uncertain significance Single submitter
- ULK3 p.Glu223Asp Uncertain significance Single submitter
- ULK3 p.Glu279Asp Uncertain significance Single submitter
- ULK3 p.Glu342Lys Uncertain significance Single submitter
- ULK3 p.Glu396Gln Uncertain significance Single submitter
- ULK3 p.Glu409Gln Uncertain significance Single submitter
- ULK3 p.Glu417Asp Uncertain significance Single submitter
- ULK3 p.Gly282Glu Uncertain significance Single submitter
- ULK3 p.Gly395Arg Uncertain significance Single submitter
- ULK3 p.His152Tyr Uncertain significance Single submitter
- ULK3 p.His405Asp Uncertain significance Single submitter
- ULK3 p.Leu178Val Uncertain significance Single submitter
- ULK3 p.Leu356Arg Uncertain significance Single submitter
- ULK3 p.Lys112Asn Uncertain significance Single submitter
- ULK3 p.Lys445Glu Uncertain significance Single submitter
- ULK3 p.Met275Ile Uncertain significance Single submitter
- ULK3 p.Met387Ile Uncertain significance Single submitter
- ULK3 p.Met446Val Uncertain significance Single submitter
- ULK3 p.Pro212Ala Uncertain significance Single submitter
- ULK3 p.Pro418Ser Uncertain significance Single submitter
- ULK3 p.Pro419Leu Uncertain significance Single submitter
- ULK3 p.Pro8Leu Uncertain significance Single submitter
- ULK3 p.Pro8Ser Uncertain significance Single submitter
- ULK3 p.Ser462Leu Uncertain significance Single submitter
- ULK3 p.Ser84Asn Uncertain significance Single submitter
- ULK3 p.Thr285Ile Uncertain significance Single submitter
- ULK3 p.Thr61Met Uncertain significance Single submitter
- ULK3 p.Tyr204Cys Uncertain significance Single submitter
- ULK3 p.Tyr307Ser Uncertain significance Single submitter
- ULK3 p.Val194Met Uncertain significance Single submitter
- ULK3 p.Val230Ile Uncertain significance Single submitter
- ULK3 p.Val230Phe Uncertain significance Single submitter
- ULK3 p.Val28Met Uncertain significance Single submitter
- ULK3 p.Val338Met Uncertain significance Single submitter
- ULK3 p.Val348Ile Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- ULK3 p.Ala399Val Uncertain significance Single submitter
- ULK3 p.Arg174His Uncertain significance Single submitter
- ULK3 p.Arg188Trp Uncertain significance Single submitter
- ULK3 p.Arg193Cys Uncertain significance Single submitter
- ULK3 p.Arg193His Uncertain significance Single submitter
- ULK3 p.Arg236Gly Uncertain significance Single submitter
- ULK3 p.Arg236Trp Uncertain significance Single submitter
- ULK3 p.Arg257Cys Uncertain significance Single submitter
- ULK3 p.Asn132Thr Uncertain significance Single submitter
- ULK3 p.Asp299Tyr Uncertain significance Single submitter
- ULK3 p.Gln141Glu Uncertain significance Single submitter
- ULK3 p.Gly394Ser Uncertain significance Single submitter
- ULK3 p.Gly408Arg Uncertain significance Single submitter
- ULK3 p.Gly7Asp Uncertain significance Single submitter
- ULK3 p.Pro237Ser Uncertain significance Single submitter
- ULK3 p.Ser147Phe Uncertain significance Single submitter
- ULK3 p.Ser361Phe Uncertain significance Single submitter
- ULK3 p.Thr27Met Uncertain significance Single submitter
All ULK3 variants
Benign 4
- p.Arg101His Multiple submitters
- p.Pro177= Multiple submitters
- p.Ser468= Multiple submitters
- c.470-4G>A Single submitter
Likely benign 6
- p.Ala284= Single submitter
- p.Ala31= Single submitter
- p.Arg450His Single submitter
- p.Leu99= Single submitter
- p.Pro166= Single submitter
- p.Ser219Leu Single submitter
Uncertain significance 79
- p.Ala114Val Single submitter ⚠
- p.Ala192Thr Single submitter ⚠
- p.Ala26Thr Single submitter ⚠
- p.Ala286Val Single submitter ⚠
- p.Ala303Thr Single submitter ⚠
- p.Ala378Thr Single submitter ⚠
- p.Ala399Val Single submitter ⚠
- p.Arg115Cys Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg188Trp Single submitter ⚠
- p.Arg193Cys Single submitter ⚠
- p.Arg193His Single submitter ⚠
- p.Arg226His Single submitter ⚠
- p.Arg236Gln Single submitter ⚠
- p.Arg236Gly Single submitter ⚠
- p.Arg236Trp Single submitter ⚠
- p.Arg244Gln Single submitter ⚠
- p.Arg253Gln Single submitter
- p.Arg257Cys Single submitter ⚠
- p.Arg257His Single submitter ⚠
- p.Arg258Cys Single submitter ⚠
- p.Arg340Trp Single submitter ⚠
- p.Arg371Trp Single submitter ⚠
- p.Arg38Cys Single submitter ⚠
- p.Arg423Gln Single submitter ⚠
- p.Arg423Trp Single submitter
- p.Arg466Cys Single submitter ⚠
- p.Asn132His Single submitter ⚠
- p.Asn132Thr Single submitter ⚠
- p.Asn352His Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Asp299Tyr Single submitter ⚠
- p.Asp83Tyr Single submitter ⚠
- p.Gln141Glu Single submitter ⚠
- p.Gln162Pro Single submitter ⚠
- p.Gln262Arg Single submitter ⚠
- p.Glu223Asp Single submitter ⚠
- p.Glu279Asp Single submitter ⚠
- p.Glu342Lys Single submitter ⚠
- p.Glu396Gln Single submitter ⚠
- p.Glu409Gln Single submitter ⚠
- p.Glu417Asp Single submitter ⚠
- p.Gly282Glu Single submitter ⚠
- p.Gly394Ser Single submitter ⚠
- p.Gly395Arg Single submitter ⚠
- p.Gly408Arg Single submitter ⚠
- p.Gly7Asp Single submitter ⚠
- p.His152Tyr Single submitter ⚠
- p.His274Asn Single submitter
- p.His405Asp Single submitter ⚠
- p.Leu178Val Single submitter ⚠
- p.Leu356Arg Single submitter ⚠
- p.Leu376Phe Single submitter
- p.Lys112Asn Single submitter ⚠
- p.Lys445Glu Single submitter ⚠
- p.Met275Ile Single submitter ⚠
- p.Met387Ile Single submitter ⚠
- p.Met446Val Single submitter ⚠
- p.Pro212Ala Single submitter ⚠
- p.Pro237Ser Single submitter ⚠
- p.Pro418Ser Single submitter ⚠
- p.Pro419Leu Single submitter ⚠
- p.Pro8Leu Single submitter ⚠
- p.Pro8Ser Single submitter ⚠
- p.Ser147Phe Single submitter ⚠
- p.Ser361Phe Single submitter ⚠
- p.Ser462Leu Single submitter ⚠
- p.Ser84Asn Single submitter ⚠
- p.Thr27Met Single submitter ⚠
- p.Thr285Ile Single submitter ⚠
- p.Thr61Met Single submitter ⚠
- p.Tyr204Cys Single submitter ⚠
- p.Tyr307Ser Single submitter ⚠
- p.Val194Met Single submitter ⚠
- p.Val230Ile Single submitter ⚠
- p.Val230Phe Single submitter ⚠
- p.Val28Met Single submitter ⚠
- p.Val338Met Single submitter ⚠
- p.Val348Ile Single submitter ⚠