ULK4 — 231 ClinVar variants
All ClinVar germline ULK4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 169 flagged for review →
19 Benign · 1 Benign/Likely benign · 32 Likely benign · 179 Uncertain significance
Full ULK4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 169
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 146
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- ULK4 p.Ala1014Thr Uncertain significance Single submitter
- ULK4 p.Ala1014Val Uncertain significance Single submitter
- ULK4 p.Ala1056Glu Uncertain significance Single submitter
- ULK4 p.Ala1251Val Uncertain significance Single submitter
- ULK4 p.Ala1261Thr Uncertain significance Single submitter
- ULK4 p.Ala249Pro Uncertain significance Single submitter
- ULK4 p.Ala31Val Uncertain significance Single submitter
- ULK4 p.Ala671Asp Uncertain significance Single submitter
- ULK4 p.Ala682Thr Uncertain significance Single submitter
- ULK4 p.Arg1152Gly Uncertain significance Single submitter
- ULK4 p.Arg1245Trp Uncertain significance Single submitter
- ULK4 p.Arg345Gln Uncertain significance Single submitter
- ULK4 p.Arg345Trp Uncertain significance Single submitter
- ULK4 p.Arg364Cys Uncertain significance Single submitter
- ULK4 p.Arg519Gln Uncertain significance Single submitter
- ULK4 p.Arg527Gln Uncertain significance Single submitter
- ULK4 p.Arg596Gly Uncertain significance Single submitter
- ULK4 p.Arg674Lys Uncertain significance Single submitter
- ULK4 p.Arg677Cys Uncertain significance Single submitter
- ULK4 p.Arg739His Uncertain significance Single submitter
- ULK4 p.Arg862Gln Uncertain significance Single submitter
- ULK4 p.Arg925His Uncertain significance Single submitter
- ULK4 p.Arg953Gln Uncertain significance Single submitter
- ULK4 p.Asn1060Ser Uncertain significance Single submitter
- ULK4 p.Asn1191Asp Uncertain significance Single submitter
- ULK4 p.Asn1230Ser Uncertain significance Single submitter
- ULK4 p.Asn139Asp Uncertain significance Single submitter
- ULK4 p.Asn301His Uncertain significance Single submitter
- ULK4 p.Asn944Ser Uncertain significance Single submitter
- ULK4 p.Asn964Asp Uncertain significance Single submitter
- ULK4 p.Asp1002Glu Uncertain significance Single submitter
- ULK4 p.Asp1259Gly Uncertain significance Single submitter
- ULK4 p.Asp165Gly Uncertain significance Single submitter
- ULK4 p.Asp201Tyr Uncertain significance Single submitter
- ULK4 p.Asp451Gly Uncertain significance Single submitter
- ULK4 p.Cys141Phe Uncertain significance Single submitter
- ULK4 p.Cys720Tyr Uncertain significance Single submitter
- ULK4 p.Gln262Lys Uncertain significance Single submitter
- ULK4 p.Gln316Arg Uncertain significance Single submitter
- ULK4 p.Gln319Arg Uncertain significance Single submitter
- ULK4 p.Gln387His Uncertain significance Single submitter
- ULK4 p.Gln965Pro Uncertain significance Single submitter
- ULK4 p.Glu1041Val Uncertain significance Single submitter
- ULK4 p.Glu1070Ala Uncertain significance Single submitter
- ULK4 p.Glu1201Asp Uncertain significance Single submitter
- ULK4 p.Glu1201Gly Uncertain significance Single submitter
- ULK4 p.Glu222Gly Uncertain significance Single submitter
- ULK4 p.Glu304Ala Uncertain significance Single submitter
- ULK4 p.Glu356Lys Uncertain significance Single submitter
- ULK4 p.Glu411Gln Uncertain significance Single submitter
- ULK4 p.Glu543Lys Uncertain significance Single submitter
- ULK4 p.Glu590Lys Uncertain significance Single submitter
- ULK4 p.Glu91Gly Uncertain significance Single submitter
- ULK4 p.Gly11Arg Uncertain significance Single submitter
- ULK4 p.Gly193Asp Uncertain significance Single submitter
- ULK4 p.Gly329Asp Uncertain significance Single submitter
- ULK4 p.Gly732Val Uncertain significance Single submitter
- ULK4 p.His1116Arg Uncertain significance Single submitter
- ULK4 p.His326Gln Uncertain significance Single submitter
- ULK4 p.His507Pro Uncertain significance Single submitter
- ULK4 p.His854Tyr Uncertain significance Single submitter
- ULK4 p.Ile1125Thr Uncertain significance Single submitter
- ULK4 p.Ile1182Thr Uncertain significance Single submitter
- ULK4 p.Ile1227Phe Uncertain significance Single submitter
- ULK4 p.Ile122Val Uncertain significance Single submitter
- ULK4 p.Ile32Val Uncertain significance Single submitter
- ULK4 p.Ile430Val Uncertain significance Single submitter
- ULK4 p.Ile526Met Uncertain significance Single submitter
- ULK4 p.Ile554Val Uncertain significance Single submitter
- ULK4 p.Ile561Val Uncertain significance Single submitter
- ULK4 p.Ile644Thr Uncertain significance Single submitter
- ULK4 p.Ile728Leu Uncertain significance Single submitter
- ULK4 p.Ile821Phe Uncertain significance Single submitter
- ULK4 p.Ile821Val Uncertain significance Single submitter
- ULK4 p.Ile87Thr Uncertain significance Single submitter
- ULK4 p.Ile914Leu Uncertain significance Single submitter
- ULK4 p.Leu1025His Uncertain significance Single submitter
- ULK4 p.Leu1025Phe Uncertain significance Single submitter
- ULK4 p.Leu1058Val Uncertain significance Single submitter
- ULK4 p.Leu1148Val Uncertain significance Single submitter
- ULK4 p.Leu1157Pro Uncertain significance Single submitter
- ULK4 p.Leu1207Pro Uncertain significance Single submitter
- ULK4 p.Leu556Ile Uncertain significance Single submitter
- ULK4 p.Leu578Pro Uncertain significance Single submitter
- ULK4 p.Leu805Phe Uncertain significance Single submitter
- ULK4 p.Leu842Arg Uncertain significance Single submitter
- ULK4 p.Leu853Ile Uncertain significance Single submitter
- ULK4 p.Leu998Pro Uncertain significance Single submitter
- ULK4 p.Lys1210Arg Uncertain significance Single submitter
- ULK4 p.Lys136Glu Uncertain significance Single submitter
- ULK4 p.Lys20Arg Uncertain significance Single submitter
- ULK4 p.Lys312Arg Uncertain significance Single submitter
- ULK4 p.Lys529Arg Uncertain significance Single submitter
- ULK4 p.Lys592Asn Uncertain significance Single submitter
- ULK4 p.Lys905Asn Uncertain significance Single submitter
- ULK4 p.Lys905Glu Uncertain significance Single submitter
- ULK4 p.Met1069Val Uncertain significance Single submitter
- ULK4 p.Phe4Leu Uncertain significance Single submitter
- ULK4 p.Pro1033Ser Uncertain significance Single submitter
- ULK4 p.Pro1166Ala Uncertain significance Single submitter
- ULK4 p.Pro1192Ser Uncertain significance Single submitter
- ULK4 p.Pro41Ala Uncertain significance Single submitter
- ULK4 p.Pro509Ser Uncertain significance Single submitter
- ULK4 p.Pro595Thr Uncertain significance Single submitter
- ULK4 p.Pro602Leu Uncertain significance Single submitter
- ULK4 p.Ser1067Leu Uncertain significance Single submitter
- ULK4 p.Ser1135Cys Uncertain significance Single submitter
- ULK4 p.Ser1254Arg Uncertain significance Single submitter
- ULK4 p.Ser1256Leu Uncertain significance Single submitter
- ULK4 p.Ser14Arg Uncertain significance Single submitter
- ULK4 p.Ser174Gly Uncertain significance Single submitter
- ULK4 p.Ser244Ala Uncertain significance Single submitter
- ULK4 p.Ser291Ala Uncertain significance Single submitter
- ULK4 p.Ser306Pro Uncertain significance Single submitter
- ULK4 p.Ser348Asn Uncertain significance Single submitter
- ULK4 p.Ser474Phe Uncertain significance Single submitter
- ULK4 p.Ser539Leu Uncertain significance Single submitter
- ULK4 p.Ser663Phe Uncertain significance Single submitter
- ULK4 p.Ser670Leu Uncertain significance Single submitter
- ULK4 p.Ser68Gly Uncertain significance Single submitter
- ULK4 p.Ser800Pro Uncertain significance Single submitter
- ULK4 p.Thr1208Ala Uncertain significance Single submitter
- ULK4 p.Thr1208Ile Uncertain significance Single submitter
- ULK4 p.Thr272Arg Uncertain significance Single submitter
- ULK4 p.Thr272Ile Uncertain significance Single submitter
- ULK4 p.Thr366Ser Uncertain significance Single submitter
- ULK4 p.Thr369Asn Uncertain significance Single submitter
- ULK4 p.Thr415Pro Uncertain significance Single submitter
- ULK4 p.Thr676Ala Uncertain significance Single submitter
- ULK4 p.Thr681Ala Uncertain significance Single submitter
- ULK4 p.Thr889Met Uncertain significance Single submitter
- ULK4 p.Thr927Met Uncertain significance Single submitter
- ULK4 p.Tyr1073Phe Uncertain significance Single submitter
- ULK4 p.Tyr414Cys Uncertain significance Single submitter
- ULK4 p.Tyr414Phe Uncertain significance Single submitter
- ULK4 p.Tyr491Cys Uncertain significance Single submitter
- ULK4 p.Tyr758His Uncertain significance Single submitter
- ULK4 p.Tyr758Phe Uncertain significance Single submitter
- ULK4 p.Val1062Asp Uncertain significance Single submitter
- ULK4 p.Val1184Ile Uncertain significance Single submitter
- ULK4 p.Val1273Ile Uncertain significance Single submitter
- ULK4 p.Val550Ile Uncertain significance Single submitter
- ULK4 p.Val585Ile Uncertain significance Single submitter
- ULK4 p.Val837Phe Uncertain significance Single submitter
- ULK4 p.Val839Leu Uncertain significance Single submitter
- ULK4 p.Val856Leu Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- ULK4 p.Asn139Lys Likely benign Multiple submitters
- ULK4 p.Arg1249Trp Uncertain significance Single submitter
- ULK4 p.Arg23Gln Uncertain significance Single submitter
- ULK4 p.Arg246Cys Uncertain significance Single submitter
- ULK4 p.Arg246His Uncertain significance Single submitter
- ULK4 p.Arg611Gly Uncertain significance Single submitter
- ULK4 p.Arg831Gly Uncertain significance Single submitter
- ULK4 p.Asn631Tyr Uncertain significance Single submitter
- ULK4 p.Asp243Gly Uncertain significance Single submitter
- ULK4 p.Asp782Glu Uncertain significance Single submitter
- ULK4 p.Cys802Arg Uncertain significance Single submitter
- ULK4 p.Glu765Val Uncertain significance Single submitter
- ULK4 p.Ile10Met Uncertain significance Single submitter
- ULK4 p.Ile687Thr Uncertain significance Single submitter
- ULK4 p.Leu202Phe Uncertain significance Single submitter
- ULK4 p.Leu998Val Uncertain significance Single submitter
- ULK4 p.Met212Ile Uncertain significance Single submitter
- ULK4 p.Phe753Ser Uncertain significance Single submitter
- ULK4 p.Ser1053Arg Uncertain significance Single submitter
- ULK4 p.Ser357Tyr Uncertain significance Single submitter
- ULK4 p.Thr676Ile Uncertain significance Single submitter
- ULK4 p.Thr712Pro Uncertain significance Single submitter
- ULK4 p.Val937Met Uncertain significance Single submitter
All ULK4 variants
Benign 19
- c.1183-8C>A Multiple submitters
- c.1288-9A>T Multiple submitters
- c.1349-5C>G Multiple submitters
- c.1577+10G>A Multiple submitters
- c.803+3A>C Multiple submitters
- p.Ala542Thr Multiple submitters
- p.Ile224Val Multiple submitters
- p.Lys39Arg Multiple submitters
- p.Ser1137= Multiple submitters
- p.Ser640Ala Multiple submitters
- p.Val533= Multiple submitters
- p.Ala542= Single submitter
- p.Ala715Thr No assertion criteria ULK4-related disorder
- p.Gly352= No assertion criteria ULK4-related disorder
- p.Leu603Ser No assertion criteria ULK4-related disorder
- p.Leu844Met No assertion criteria ULK4-related disorder
- p.Lys569Arg No assertion criteria ULK4-related disorder
- p.Ser348Gly No assertion criteria ULK4-related disorder
- p.Val851Ile No assertion criteria ULK4-related disorder
Benign/Likely benign 1
- p.Ser1067= Multiple submitters
Likely benign 32
- p.Asn139Lys Multiple submitters ⚠
- p.Val686Ile Multiple submitters Moderate intellectual disability
- p.Arg51His Single submitter
- p.Arg739= Single submitter
- p.Arg862Ter Single submitter Moderate intellectual disability
- p.Arg925Cys Single submitter
- p.Asn301= Single submitter
- p.Asn981Ser Single submitter
- p.Asp165Asn Single submitter
- p.Glu374Gly Single submitter
- p.Ile737Val Single submitter
- p.Leu142= Single submitter
- p.Leu570Phe Single submitter
- p.Leu844= Single submitter
- p.Pro1106Ala Single submitter
- p.Pro183Leu Single submitter
- p.Ser975Asn Single submitter
- p.Thr1021Ala Single submitter
- p.Val145= Single submitter
- p.Val179= Single submitter
- p.Val293Ile Single submitter
- p.Val963Met Single submitter Moderate intellectual disability
- c.1764+3G>A No assertion criteria ULK4-related disorder
- c.2687-10_2687-9del No assertion criteria ULK4-related disorder
- c.896+5T>G No assertion criteria ULK4-related disorder
- p.Asn796= No assertion criteria ULK4-related disorder
- p.Gln387Arg No assertion criteria ULK4-related disorder
- p.His55= No assertion criteria ULK4-related disorder
- p.Leu1084= No assertion criteria ULK4-related disorder
- p.Pro847= No assertion criteria ULK4-related disorder
- p.Ser292= No assertion criteria ULK4-related disorder
- p.Ser883= No assertion criteria ULK4-related disorder
Uncertain significance 179
- p.Ala1014Thr Single submitter ⚠
- p.Ala1014Val Single submitter ⚠
- p.Ala1056Glu Single submitter ⚠
- p.Ala1251Val Single submitter ⚠
- p.Ala1261Thr Single submitter ⚠
- p.Ala249Pro Single submitter ⚠
- p.Ala31Val Single submitter ⚠
- p.Ala671Asp Single submitter ⚠
- p.Ala682Thr Single submitter ⚠
- p.Arg1152Gly Single submitter ⚠
- p.Arg1245Trp Single submitter ⚠
- p.Arg1249Trp Single submitter ⚠
- p.Arg23Gln Single submitter ⚠
- p.Arg246Cys Single submitter ⚠
- p.Arg246His Single submitter ⚠
- p.Arg345Gln Single submitter ⚠
- p.Arg345Trp Single submitter ⚠
- p.Arg364Cys Single submitter ⚠
- p.Arg483Gly Single submitter
- p.Arg48Cys Single submitter
- p.Arg519Gln Single submitter ⚠
- p.Arg527Gln Single submitter ⚠
- p.Arg596Gly Single submitter ⚠
- p.Arg611Gly Single submitter ⚠
- p.Arg674Lys Single submitter ⚠
- p.Arg677Cys Single submitter ⚠
- p.Arg739His Single submitter ⚠
- p.Arg831Gly Single submitter ⚠
- p.Arg862Gln Single submitter ⚠
- p.Arg925His Single submitter ⚠
- p.Arg953Gln Single submitter ⚠
- p.Asn1060Ser Single submitter ⚠
- p.Asn1191Asp Single submitter ⚠
- p.Asn1230Ser Single submitter ⚠
- p.Asn139Asp Single submitter ⚠
- p.Asn301His Single submitter ⚠
- p.Asn631Tyr Single submitter ⚠
- p.Asn944Ser Single submitter ⚠
- p.Asn964Asp Single submitter ⚠
- p.Asp1002Glu Single submitter ⚠
- p.Asp1259Gly Single submitter ⚠
- p.Asp165Gly Single submitter ⚠
- p.Asp201Tyr Single submitter ⚠
- p.Asp243Gly Single submitter ⚠
- p.Asp451Gly Single submitter ⚠
- p.Asp782Glu Single submitter ⚠
- p.Cys141Phe Single submitter ⚠
- p.Cys720Tyr Single submitter ⚠
- p.Cys802Arg Single submitter ⚠
- p.Gln262Lys Single submitter ⚠
- p.Gln316Arg Single submitter ⚠
- p.Gln319Arg Single submitter ⚠
- p.Gln387His Single submitter ⚠
- p.Gln838Pro Single submitter
- p.Gln965Pro Single submitter ⚠
- p.Glu1041Val Single submitter ⚠
- p.Glu1070Ala Single submitter ⚠
- p.Glu1201Asp Single submitter ⚠
- p.Glu1201Gly Single submitter ⚠
- p.Glu222Gly Single submitter ⚠
- p.Glu304Ala Single submitter ⚠
- p.Glu356Lys Single submitter ⚠
- p.Glu411Gln Single submitter ⚠
- p.Glu543Lys Single submitter ⚠
- p.Glu590Lys Single submitter ⚠
- p.Glu765Val Single submitter ⚠
- p.Glu91Gly Single submitter ⚠
- p.Gly11Arg Single submitter ⚠
- p.Gly193Asp Single submitter ⚠
- p.Gly329Asp Single submitter ⚠
- p.Gly732Val Single submitter ⚠
- p.His1116Arg Single submitter ⚠
- p.His326Gln Single submitter ⚠
- p.His507Pro Single submitter ⚠
- p.His854Tyr Single submitter ⚠
- p.Ile10Met Single submitter ⚠
- p.Ile1125Thr Single submitter ⚠
- p.Ile1172Thr Single submitter
- p.Ile1182Thr Single submitter ⚠
- p.Ile1227Phe Single submitter ⚠
- p.Ile122Val Single submitter ⚠
- p.Ile32Val Single submitter ⚠
- p.Ile430Val Single submitter ⚠
- p.Ile526Met Single submitter ⚠
- p.Ile554Val Single submitter ⚠
- p.Ile561Val Single submitter ⚠
- p.Ile644Thr Single submitter ⚠
- p.Ile687Thr Single submitter ⚠
- p.Ile728Leu Single submitter ⚠
- p.Ile821Phe Single submitter ⚠
- p.Ile821Val Single submitter ⚠
- p.Ile87Thr Single submitter ⚠
- p.Ile914Leu Single submitter ⚠
- p.Leu1025His Single submitter ⚠
- p.Leu1025Phe Single submitter ⚠
- p.Leu1040Pro Single submitter
- p.Leu1058Val Single submitter ⚠
- p.Leu112Phe Single submitter
- p.Leu1148Val Single submitter ⚠
- p.Leu1157Pro Single submitter ⚠
- p.Leu1207Pro Single submitter ⚠
- p.Leu202Phe Single submitter ⚠
- p.Leu556Ile Single submitter ⚠
- p.Leu578Pro Single submitter ⚠
- p.Leu805Phe Single submitter ⚠
- p.Leu842Arg Single submitter ⚠
- p.Leu853Ile Single submitter ⚠
- p.Leu998Pro Single submitter ⚠
- p.Leu998Val Single submitter ⚠
- p.Lys1210Arg Single submitter ⚠
- p.Lys136Glu Single submitter ⚠
- p.Lys20Arg Single submitter ⚠
- p.Lys312Arg Single submitter ⚠
- p.Lys529Arg Single submitter ⚠
- p.Lys592Asn Single submitter ⚠
- p.Lys905Asn Single submitter ⚠
- p.Lys905Glu Single submitter ⚠
- p.Met1069Val Single submitter ⚠
- p.Met212Ile Single submitter ⚠
- p.Phe4Leu Single submitter ⚠
- p.Phe753Ser Single submitter ⚠
- p.Phe950Ser Single submitter
- p.Pro1033Ser Single submitter ⚠
- p.Pro1166Ala Single submitter ⚠
- p.Pro1192Ser Single submitter ⚠
- p.Pro41Ala Single submitter ⚠
- p.Pro509Ser Single submitter ⚠
- p.Pro595Thr Single submitter ⚠
- p.Pro602Leu Single submitter ⚠
- p.Pro680His Single submitter
- p.Pro94Arg Single submitter
- p.Ser1053Arg Single submitter ⚠
- p.Ser1067Leu Single submitter ⚠
- p.Ser1135Cys Single submitter ⚠
- p.Ser1254Arg Single submitter ⚠
- p.Ser1256Leu Single submitter ⚠
- p.Ser14Arg Single submitter ⚠
- p.Ser174Gly Single submitter ⚠
- p.Ser244Ala Single submitter ⚠
- p.Ser291Ala Single submitter ⚠
- p.Ser306Pro Single submitter ⚠
- p.Ser348Asn Single submitter ⚠
- p.Ser357Tyr Single submitter ⚠
- p.Ser474Phe Single submitter ⚠
- p.Ser539Leu Single submitter ⚠
- p.Ser663Phe Single submitter ⚠
- p.Ser670Leu Single submitter ⚠
- p.Ser68Gly Single submitter ⚠
- p.Ser800Pro Single submitter ⚠
- p.Thr1208Ala Single submitter ⚠
- p.Thr1208Ile Single submitter ⚠
- p.Thr272Arg Single submitter ⚠
- p.Thr272Ile Single submitter ⚠
- p.Thr366Ser Single submitter ⚠
- p.Thr369Asn Single submitter ⚠
- p.Thr415Pro Single submitter ⚠
- p.Thr422Ile Single submitter
- p.Thr676Ala Single submitter ⚠
- p.Thr676Ile Single submitter ⚠
- p.Thr681Ala Single submitter ⚠
- p.Thr712Pro Single submitter ⚠
- p.Thr889Met Single submitter ⚠
- p.Thr927Met Single submitter ⚠
- p.Tyr1073Phe Single submitter ⚠
- p.Tyr1187Cys Single submitter
- p.Tyr414Cys Single submitter ⚠
- p.Tyr414Phe Single submitter ⚠
- p.Tyr491Cys Single submitter ⚠
- p.Tyr758His Single submitter ⚠
- p.Tyr758Phe Single submitter ⚠
- p.Val1062Asp Single submitter ⚠
- p.Val1184Ile Single submitter ⚠
- p.Val1273Ile Single submitter ⚠
- p.Val550Ile Single submitter ⚠
- p.Val585Ile Single submitter ⚠
- p.Val837Phe Single submitter ⚠
- p.Val839Leu Single submitter ⚠
- p.Val856Leu Single submitter ⚠
- p.Val937Met Single submitter ⚠