USP1 — 87 ClinVar variants
All ClinVar germline USP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
2 Benign · 3 Likely benign · 82 Uncertain significance
Full USP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP1 p.Ala632Val Uncertain significance Single submitter
- USP1 p.Ala64Val Uncertain significance Single submitter
- USP1 p.Ala694Val Uncertain significance Single submitter
- USP1 p.Arg329Gly Uncertain significance Single submitter
- USP1 p.Arg633Gly Uncertain significance Single submitter
- USP1 p.Asn364Lys Uncertain significance Single submitter
- USP1 p.Asn682Ser Uncertain significance Single submitter
- USP1 p.Asn682Tyr Uncertain significance Single submitter
- USP1 p.Asn76Asp Uncertain significance Single submitter
- USP1 p.Asp377Val Uncertain significance Single submitter
- USP1 p.Asp381Tyr Uncertain significance Single submitter
- USP1 p.Gln332Lys Uncertain significance Single submitter
- USP1 p.Gln348Glu Uncertain significance Single submitter
- USP1 p.Gln365Arg Uncertain significance Single submitter
- USP1 p.Gln365His Uncertain significance Single submitter
- USP1 p.Gln420Glu Uncertain significance Single submitter
- USP1 p.Gln59Lys Uncertain significance Single submitter
- USP1 p.Glu262Ala Uncertain significance Single submitter
- USP1 p.Glu262Lys Uncertain significance Single submitter
- USP1 p.Glu295Asp Uncertain significance Single submitter
- USP1 p.Glu375Lys Uncertain significance Single submitter
- USP1 p.Glu397Ala Uncertain significance Single submitter
- USP1 p.Glu470Asp Uncertain significance Single submitter
- USP1 p.Gly104Ser Uncertain significance Single submitter
- USP1 p.Gly395Arg Uncertain significance Single submitter
- USP1 p.His710Arg Uncertain significance Single submitter
- USP1 p.Ile246Val Uncertain significance Single submitter
- USP1 p.Ile317Val Uncertain significance Single submitter
- USP1 p.Ile339Val Uncertain significance Single submitter
- USP1 p.Ile414Val Uncertain significance Single submitter
- USP1 p.Ile528Val Uncertain significance Single submitter
- USP1 p.Ile646Val Uncertain significance Single submitter
- USP1 p.Leu396Ile Uncertain significance Single submitter
- USP1 p.Leu465Val Uncertain significance Single submitter
- USP1 p.Leu560Phe Uncertain significance Single submitter
- USP1 p.Leu603Phe Uncertain significance Single submitter
- USP1 p.Leu658Trp Uncertain significance Single submitter
- USP1 p.Leu764Val Uncertain significance Single submitter
- USP1 p.Lys169Arg Uncertain significance Single submitter
- USP1 p.Lys288Met Uncertain significance Single submitter
- USP1 p.Lys732Arg Uncertain significance Single submitter
- USP1 p.Met254Arg Uncertain significance Single submitter
- USP1 p.Phe695Leu Uncertain significance Single submitter
- USP1 p.Pro239Leu Uncertain significance Single submitter
- USP1 p.Pro265Ala Uncertain significance Single submitter
- USP1 p.Pro265Leu Uncertain significance Single submitter
- USP1 p.Pro624Thr Uncertain significance Single submitter
- USP1 p.Pro687Ser Uncertain significance Single submitter
- USP1 p.Ser139Phe Uncertain significance Single submitter
- USP1 p.Ser13Pro Uncertain significance Single submitter
- USP1 p.Ser148Gly Uncertain significance Single submitter
- USP1 p.Ser16Cys Uncertain significance Single submitter
- USP1 p.Ser287Pro Uncertain significance Single submitter
- USP1 p.Ser323Phe Uncertain significance Single submitter
- USP1 p.Ser685Ala Uncertain significance Single submitter
- USP1 p.Thr346Ala Uncertain significance Single submitter
- USP1 p.Thr362Ser Uncertain significance Single submitter
- USP1 p.Thr390Ala Uncertain significance Single submitter
- USP1 p.Thr402Ser Uncertain significance Single submitter
- USP1 p.Thr693Ile Uncertain significance Single submitter
- USP1 p.Thr706Ser Uncertain significance Single submitter
- USP1 p.Thr771Pro Uncertain significance Single submitter
- USP1 p.Tyr743Cys Uncertain significance Single submitter
- USP1 p.Val367Gly Uncertain significance Single submitter
- USP1 p.Val408Asp Uncertain significance Single submitter
- USP1 p.Val663Ala Uncertain significance Single submitter
- USP1 p.Val737Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- USP1 p.Asp502Glu Uncertain significance Single submitter
- USP1 p.Gln197His Uncertain significance Single submitter
- USP1 p.Gly546Asp Uncertain significance Single submitter
- USP1 p.Leu188Arg Uncertain significance Single submitter
- USP1 p.Lys354Glu Uncertain significance Single submitter
- USP1 p.Pro478Ser Uncertain significance Single submitter
- USP1 p.Ser518Asn Uncertain significance Single submitter
- USP1 p.Tyr195Cys Uncertain significance Single submitter
All USP1 variants
Likely benign 3
- p.Asn640Asp Single submitter
- p.Ile322Val Single submitter
- p.Ile666Val Single submitter
Uncertain significance 82
- p.Ala632Val Single submitter ⚠
- p.Ala64Val Single submitter ⚠
- p.Ala694Val Single submitter ⚠
- p.Arg329Gly Single submitter ⚠
- p.Arg439His Single submitter
- p.Arg633Gly Single submitter ⚠
- p.Asn364Lys Single submitter ⚠
- p.Asn682Ser Single submitter ⚠
- p.Asn682Tyr Single submitter ⚠
- p.Asn76Asp Single submitter ⚠
- p.Asp377Val Single submitter ⚠
- p.Asp381Tyr Single submitter ⚠
- p.Asp502Glu Single submitter ⚠
- p.Gln197His Single submitter ⚠
- p.Gln332Lys Single submitter ⚠
- p.Gln348Glu Single submitter ⚠
- p.Gln365Arg Single submitter ⚠
- p.Gln365His Single submitter ⚠
- p.Gln420Glu Single submitter ⚠
- p.Gln59Lys Single submitter ⚠
- p.Glu262Ala Single submitter ⚠
- p.Glu262Lys Single submitter ⚠
- p.Glu295Asp Single submitter ⚠
- p.Glu375Lys Single submitter ⚠
- p.Glu375Ter Single submitter
- p.Glu397Ala Single submitter ⚠
- p.Glu470Asp Single submitter ⚠
- p.Gly104Ser Single submitter ⚠
- p.Gly395Arg Single submitter ⚠
- p.Gly546Asp Single submitter ⚠
- p.His710Arg Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Ile339Val Single submitter ⚠
- p.Ile414Val Single submitter ⚠
- p.Ile456Val Single submitter
- p.Ile528Val Single submitter ⚠
- p.Ile646Val Single submitter ⚠
- p.Leu188Arg Single submitter ⚠
- p.Leu396Ile Single submitter ⚠
- p.Leu465Val Single submitter ⚠
- p.Leu560Phe Single submitter ⚠
- p.Leu603Phe Single submitter ⚠
- p.Leu658Trp Single submitter ⚠
- p.Leu749Phe Single submitter
- p.Leu764Val Single submitter ⚠
- p.Leu83Met Single submitter
- p.Lys169Arg Single submitter ⚠
- p.Lys288Met Single submitter ⚠
- p.Lys354Glu Single submitter ⚠
- p.Lys732Arg Single submitter ⚠
- p.Met254Arg Single submitter ⚠
- p.Phe695Leu Single submitter ⚠
- p.Pro239Leu Single submitter ⚠
- p.Pro265Ala Single submitter ⚠
- p.Pro265Leu Single submitter ⚠
- p.Pro349Leu Single submitter
- p.Pro478Ser Single submitter ⚠
- p.Pro624Thr Single submitter ⚠
- p.Pro687Ser Single submitter ⚠
- p.Ser139Phe Single submitter ⚠
- p.Ser13Pro Single submitter ⚠
- p.Ser148Gly Single submitter ⚠
- p.Ser16Cys Single submitter ⚠
- p.Ser287Pro Single submitter ⚠
- p.Ser323Phe Single submitter ⚠
- p.Ser518Asn Single submitter ⚠
- p.Ser685Ala Single submitter ⚠
- p.Thr346Ala Single submitter ⚠
- p.Thr362Ser Single submitter ⚠
- p.Thr390Ala Single submitter ⚠
- p.Thr402Ser Single submitter ⚠
- p.Thr693Ile Single submitter ⚠
- p.Thr706Ser Single submitter ⚠
- p.Thr771Pro Single submitter ⚠
- p.Tyr100His Single submitter
- p.Tyr195Cys Single submitter ⚠
- p.Tyr743Cys Single submitter ⚠
- p.Val367Gly Single submitter ⚠
- p.Val408Asp Single submitter ⚠
- p.Val663Ala Single submitter ⚠
- p.Val737Met Single submitter ⚠