USP10 — 146 ClinVar variants

All ClinVar germline USP10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 133 flagged for review →

9 Likely benign · 137 Uncertain significance

Full USP10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 133

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 119

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 14

The independent predictors disagree with each other — read with care.

All USP10 variants

Likely benign 9

p.Ala108Val Single submitter
p.Ala132Val Single submitter
p.Ala248Thr Single submitter
p.Asn743Ser Single submitter
p.Gly230Arg Single submitter
p.Gly93Ser Single submitter
p.Ser203= Single submitter
p.Ser293Leu Single submitter
p.Thr315Ala Single submitter

Uncertain significance 137

p.Ala108Gly Single submitter ⚠
p.Ala123Thr Single submitter ⚠
p.Ala132Ser Single submitter ⚠
p.Ala239Ser Single submitter ⚠
p.Ala259Gly Single submitter ⚠
p.Ala270Thr Single submitter ⚠
p.Ala298Pro Single submitter ⚠
p.Ala320Val Single submitter ⚠
p.Ala358Pro Single submitter ⚠
p.Ala368Ser Single submitter ⚠
p.Ala44Gly Single submitter ⚠
p.Ala44Val Single submitter ⚠
p.Ala497Gly Single submitter ⚠
p.Ala745Val Single submitter ⚠
p.Arg149His Single submitter ⚠
p.Arg467Gln Single submitter ⚠
p.Arg494Cys Single submitter ⚠
p.Arg586Trp Single submitter ⚠
p.Arg593His Single submitter ⚠
p.Arg688Gly Single submitter ⚠
p.Arg730Gln Single submitter ⚠
p.Arg730Gly Single submitter ⚠
p.Arg733Gln Single submitter ⚠
p.Arg73Thr Single submitter ⚠
p.Arg764Cys Single submitter ⚠
p.Arg764His Single submitter ⚠
p.Arg785Cys Single submitter ⚠
p.Arg793Cys Single submitter ⚠
p.Arg794Gln Single submitter ⚠
p.Asn19Ser Single submitter ⚠
p.Asn281Ile Single submitter ⚠
p.Asn300Ser Single submitter ⚠
p.Asn550Ser Single submitter ⚠
p.Asn565Ser Single submitter ⚠
p.Asp125Gly Single submitter ⚠
p.Asp169His Single submitter ⚠
p.Asp277Asn Single submitter ⚠
p.Asp311Ala Single submitter ⚠
p.Asp348Tyr Single submitter ⚠
p.Asp50Val Single submitter ⚠
p.Asp69Val Single submitter ⚠
p.Gln43Glu Single submitter ⚠
p.Gln55His Single submitter ⚠
p.Gln582Lys Single submitter ⚠
p.Gln617His Single submitter ⚠
p.Gln632Pro Single submitter
p.Gln665Arg Single submitter
p.Glu107Gly Single submitter ⚠
p.Glu174Ala Single submitter ⚠
p.Glu303Gln Single submitter ⚠
p.Glu389Ala Single submitter ⚠
p.Glu389Gly Single submitter ⚠
p.Glu58Gln Single submitter ⚠
p.Gly103Cys Single submitter ⚠
p.Gly111Val Single submitter ⚠
p.Gly139Val Single submitter ⚠
p.Gly158Glu Single submitter ⚠
p.Gly166Ser Single submitter ⚠
p.Gly244Trp Single submitter ⚠
p.Gly245Val Single submitter ⚠
p.Gly296Val Single submitter ⚠
p.Gly301Trp Single submitter ⚠
p.Gly486Arg Single submitter ⚠
p.Gly519Arg Single submitter ⚠
p.Gly748Ser Single submitter ⚠
p.Ile418Leu Single submitter ⚠
p.Ile493Val Single submitter ⚠
p.Ile610Val Single submitter ⚠
p.Ile669Val Single submitter ⚠
p.Ile9Val Single submitter ⚠
p.Leu122Phe Single submitter ⚠
p.Leu232Val Single submitter ⚠
p.Leu485Val Single submitter ⚠
p.Leu508Val Single submitter ⚠
p.Leu546Val Single submitter ⚠
p.Leu553Phe Single submitter ⚠
p.Leu789Ile Single submitter
p.Lys512Glu Single submitter
p.Lys98Arg Single submitter ⚠
p.Phe21Leu Single submitter ⚠
p.Phe59Tyr Single submitter ⚠
p.Phe629Leu Single submitter ⚠
p.Pro201Leu Single submitter ⚠
p.Pro317His Single submitter ⚠
p.Pro322Thr Single submitter ⚠
p.Pro339Arg Single submitter ⚠
p.Pro356Leu Single submitter ⚠
p.Pro386Thr Single submitter ⚠
p.Pro437Leu Single submitter ⚠
p.Pro481Ser Single submitter ⚠
p.Pro548Ala Single submitter ⚠
p.Pro67His Single submitter ⚠
p.Pro72Arg Single submitter ⚠
p.Pro72Leu Single submitter ⚠
p.Ser127Arg Single submitter ⚠
p.Ser161Gly Single submitter ⚠
p.Ser170Asn Single submitter ⚠
p.Ser211Asn Single submitter ⚠
p.Ser211Cys Single submitter ⚠
p.Ser220Gly Single submitter ⚠
p.Ser226Ile Single submitter ⚠
p.Ser234Asn Single submitter ⚠
p.Ser292Tyr Single submitter ⚠
p.Ser514Asn Single submitter ⚠
p.Ser549Thr Single submitter ⚠
p.Ser637Ala Single submitter ⚠
p.Ser81Gly Single submitter ⚠
p.Thr105Ser Single submitter ⚠
p.Thr173Ala Single submitter ⚠
p.Thr205Lys Single submitter ⚠
p.Thr205Met Single submitter ⚠
p.Thr208Ser Single submitter ⚠
p.Thr24Ile Single submitter ⚠
p.Thr278Asn Single submitter ⚠
p.Thr279Ala Single submitter ⚠
p.Thr306Ser Single submitter ⚠
p.Thr307Met Single submitter ⚠
p.Thr315Pro Single submitter ⚠
p.Thr333Ser Single submitter ⚠
p.Thr37Arg Single submitter ⚠
p.Thr404Ile Single submitter ⚠
p.Thr554Ala Single submitter ⚠
p.Thr554Arg Single submitter ⚠
p.Thr554Lys Single submitter ⚠
p.Thr694Ile Single submitter ⚠
p.Thr731Ser Single submitter ⚠
p.Thr82Ile Single submitter ⚠
p.Tyr791Cys Single submitter ⚠
p.Val130Met Single submitter ⚠
p.Val185Ile Single submitter ⚠
p.Val189Leu Single submitter ⚠
p.Val223Met Single submitter ⚠
p.Val23Leu Single submitter ⚠
p.Val274Ile Single submitter ⚠
p.Val373Leu Single submitter ⚠
p.Val434Ile Single submitter ⚠
p.Val510Ala Single submitter ⚠