USP13 — 128 ClinVar variants
All ClinVar germline USP13 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 115 flagged for review →
2 Benign · 1 Benign/Likely benign · 3 Likely benign · 122 Uncertain significance
Full USP13 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 115
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP13 p.Ala103Val Uncertain significance Single submitter
- USP13 p.Ala21Thr Uncertain significance Single submitter
- USP13 p.Ala504Val Uncertain significance Single submitter
- USP13 p.Ala516Val Uncertain significance Single submitter
- USP13 p.Ala526Thr Uncertain significance Single submitter
- USP13 p.Ala683Thr Uncertain significance Single submitter
- USP13 p.Ala6Ser Uncertain significance Single submitter
- USP13 p.Ala711Pro Uncertain significance Single submitter
- USP13 p.Ala716Ser Uncertain significance Single submitter
- USP13 p.Ala734Val Uncertain significance Single submitter
- USP13 p.Arg217Gln Uncertain significance Single submitter
- USP13 p.Arg427His Uncertain significance Single submitter
- USP13 p.Arg487Gln Uncertain significance Single submitter
- USP13 p.Arg490Cys Uncertain significance Single submitter
- USP13 p.Arg494Ser Uncertain significance Single submitter
- USP13 p.Arg4Gln Uncertain significance Single submitter
- USP13 p.Arg528Lys Uncertain significance Single submitter
- USP13 p.Arg536His Uncertain significance Single submitter
- USP13 p.Arg617Thr Uncertain significance Single submitter
- USP13 p.Arg642Leu Uncertain significance Single submitter
- USP13 p.Asn127His Uncertain significance Single submitter
- USP13 p.Asn193Lys Uncertain significance Single submitter
- USP13 p.Asn194Ser Uncertain significance Single submitter
- USP13 p.Asn744Ser Uncertain significance Single submitter
- USP13 p.Asn783Ser Uncertain significance Single submitter
- USP13 p.Asp124Gly Uncertain significance Single submitter
- USP13 p.Asp130Asn Uncertain significance Single submitter
- USP13 p.Asp496Gly Uncertain significance Single submitter
- USP13 p.Asp54Ala Uncertain significance Single submitter
- USP13 p.Asp610Gly Uncertain significance Single submitter
- USP13 p.Asp654Tyr Uncertain significance Single submitter
- USP13 p.Asp762Asn Uncertain significance Single submitter
- USP13 p.Asp775Glu Uncertain significance Single submitter
- USP13 p.Gln485Arg Uncertain significance Single submitter
- USP13 p.Gln584Lys Uncertain significance Single submitter
- USP13 p.Glu247Asp Uncertain significance Single submitter
- USP13 p.Glu277Ala Uncertain significance Single submitter
- USP13 p.Glu277Gln Uncertain significance Single submitter
- USP13 p.Glu302Lys Uncertain significance Single submitter
- USP13 p.Glu533Gln Uncertain significance Single submitter
- USP13 p.Glu663Lys Uncertain significance Single submitter
- USP13 p.Glu795Lys Uncertain significance Single submitter
- USP13 p.Gly15Arg Uncertain significance Single submitter
- USP13 p.Gly201Arg Uncertain significance Single submitter
- USP13 p.Gly240Glu Uncertain significance Single submitter
- USP13 p.Gly241Cys Uncertain significance Single submitter
- USP13 p.Gly300Ala Uncertain significance Single submitter
- USP13 p.Gly324Asp Uncertain significance Single submitter
- USP13 p.Gly707Asp Uncertain significance Single submitter
- USP13 p.Gly720Asp Uncertain significance Single submitter
- USP13 p.Gly9Arg Uncertain significance Single submitter
- USP13 p.His299Asn Uncertain significance Single submitter
- USP13 p.Ile162Val Uncertain significance Single submitter
- USP13 p.Ile263Val Uncertain significance Single submitter
- USP13 p.Ile320Thr Uncertain significance Single submitter
- USP13 p.Ile629Val Uncertain significance Single submitter
- USP13 p.Ile861Val Uncertain significance Single submitter
- USP13 p.Leu126Val Uncertain significance Single submitter
- USP13 p.Leu668Met Uncertain significance Single submitter
- USP13 p.Lys210Glu Uncertain significance Single submitter
- USP13 p.Lys328Gln Uncertain significance Single submitter
- USP13 p.Met295Thr Uncertain significance Single submitter
- USP13 p.Met330Val Uncertain significance Single submitter
- USP13 p.Met428Thr Uncertain significance Single submitter
- USP13 p.Met499Ile Uncertain significance Single submitter
- USP13 p.Met694Leu Uncertain significance Single submitter
- USP13 p.Met855Val Uncertain significance Single submitter
- USP13 p.Pro403Leu Uncertain significance Single submitter
- USP13 p.Pro578Ala Uncertain significance Single submitter
- USP13 p.Pro631Ala Uncertain significance Single submitter
- USP13 p.Pro702Leu Uncertain significance Single submitter
- USP13 p.Pro797Arg Uncertain significance Single submitter
- USP13 p.Ser14Asn Uncertain significance Single submitter
- USP13 p.Ser466Pro Uncertain significance Single submitter
- USP13 p.Ser656Leu Uncertain significance Single submitter
- USP13 p.Ser774Thr Uncertain significance Single submitter
- USP13 p.Thr336Met Uncertain significance Single submitter
- USP13 p.Thr520Arg Uncertain significance Single submitter
- USP13 p.Thr520Met Uncertain significance Single submitter
- USP13 p.Trp182Arg Uncertain significance Single submitter
- USP13 p.Tyr174Cys Uncertain significance Single submitter
- USP13 p.Tyr271Phe Uncertain significance Single submitter
- USP13 p.Tyr346Ser Uncertain significance Single submitter
- USP13 p.Val412Met Uncertain significance Single submitter
- USP13 p.Val477Met Uncertain significance Single submitter
- USP13 p.Val733Ile Uncertain significance Single submitter
Predictors split 29
The independent predictors disagree with each other — read with care.
- USP13 p.Arg370Ser Uncertain significance Single submitter
- USP13 p.Arg427Cys Uncertain significance Single submitter
- USP13 p.Arg444Lys Uncertain significance Single submitter
- USP13 p.Arg463His Uncertain significance Single submitter
- USP13 p.Arg487Trp Uncertain significance Single submitter
- USP13 p.Arg536Cys Uncertain significance Single submitter
- USP13 p.Arg573Cys Uncertain significance Single submitter
- USP13 p.Arg615Gln Uncertain significance Single submitter
- USP13 p.Asn242Ser Uncertain significance Single submitter
- USP13 p.Asn756Lys Uncertain significance Single submitter
- USP13 p.Asp54Asn Uncertain significance Single submitter
- USP13 p.Gly25Ala Uncertain significance Single submitter
- USP13 p.Gly267Arg Uncertain significance Single submitter
- USP13 p.Gly60Asp Uncertain significance Single submitter
- USP13 p.His31Gln Uncertain significance Single submitter
- USP13 p.His767Arg Uncertain significance Single submitter
- USP13 p.Ile539Met Uncertain significance Single submitter
- USP13 p.Ile747Asn Uncertain significance Single submitter
- USP13 p.Met351Thr Uncertain significance Single submitter
- USP13 p.Phe117Leu Uncertain significance Single submitter
- USP13 p.Pro426Leu Uncertain significance Single submitter
- USP13 p.Pro438Leu Uncertain significance Single submitter
- USP13 p.Pro631Thr Uncertain significance Single submitter
- USP13 p.Ser239Cys Uncertain significance Single submitter
- USP13 p.Ser239Phe Uncertain significance Single submitter
- USP13 p.Ser442Cys Uncertain significance Single submitter
- USP13 p.Ser717Cys Uncertain significance Single submitter
- USP13 p.Thr385Ile Uncertain significance Single submitter
- USP13 p.Val412Leu Uncertain significance Single submitter
All USP13 variants
Benign/Likely benign 1
- c.1921+5C>T Multiple submitters
Uncertain significance 122
- p.Ala103Val Single submitter ⚠
- p.Ala21Thr Single submitter ⚠
- p.Ala504Val Single submitter ⚠
- p.Ala516Val Single submitter ⚠
- p.Ala526Thr Single submitter ⚠
- p.Ala683Thr Single submitter ⚠
- p.Ala6Ser Single submitter ⚠
- p.Ala711Pro Single submitter ⚠
- p.Ala716Ser Single submitter ⚠
- p.Ala734Val Single submitter ⚠
- p.Arg217Gln Single submitter ⚠
- p.Arg370Ser Single submitter ⚠
- p.Arg427Cys Single submitter ⚠
- p.Arg427His Single submitter ⚠
- p.Arg444Lys Single submitter ⚠
- p.Arg463His Single submitter ⚠
- p.Arg487Gln Single submitter ⚠
- p.Arg487Trp Single submitter ⚠
- p.Arg490Cys Single submitter ⚠
- p.Arg494Ser Single submitter ⚠
- p.Arg4Gln Single submitter ⚠
- p.Arg528Lys Single submitter ⚠
- p.Arg536Cys Single submitter ⚠
- p.Arg536His Single submitter ⚠
- p.Arg573Cys Single submitter ⚠
- p.Arg615Gln Single submitter ⚠
- p.Arg617Thr Single submitter ⚠
- p.Arg642Leu Single submitter ⚠
- p.Asn127His Single submitter ⚠
- p.Asn193Lys Single submitter ⚠
- p.Asn194Ser Single submitter ⚠
- p.Asn242Ser Single submitter ⚠
- p.Asn744Ser Single submitter ⚠
- p.Asn756Lys Single submitter ⚠
- p.Asn783Ser Single submitter ⚠
- p.Asp124Gly Single submitter ⚠
- p.Asp130Asn Single submitter ⚠
- p.Asp496Gly Single submitter ⚠
- p.Asp54Ala Single submitter ⚠
- p.Asp54Asn Single submitter ⚠
- p.Asp610Gly Single submitter ⚠
- p.Asp654Tyr Single submitter ⚠
- p.Asp762Asn Single submitter ⚠
- p.Asp775Glu Single submitter ⚠
- p.Gln411Pro Single submitter
- p.Gln485Arg Single submitter ⚠
- p.Gln584Lys Single submitter ⚠
- p.Glu247Asp Single submitter ⚠
- p.Glu277Ala Single submitter ⚠
- p.Glu277Gln Single submitter ⚠
- p.Glu302Lys Single submitter ⚠
- p.Glu533Gln Single submitter ⚠
- p.Glu625Asp Single submitter
- p.Glu625Gly Single submitter
- p.Glu663Lys Single submitter ⚠
- p.Glu795Lys Single submitter ⚠
- p.Gly15Arg Single submitter ⚠
- p.Gly201Arg Single submitter ⚠
- p.Gly240Glu Single submitter ⚠
- p.Gly241Cys Single submitter ⚠
- p.Gly25Ala Single submitter ⚠
- p.Gly267Arg Single submitter ⚠
- p.Gly300Ala Single submitter ⚠
- p.Gly324Asp Single submitter ⚠
- p.Gly60Asp Single submitter ⚠
- p.Gly707Asp Single submitter ⚠
- p.Gly720Asp Single submitter ⚠
- p.Gly9Arg Single submitter ⚠
- p.His299Asn Single submitter ⚠
- p.His31Gln Single submitter ⚠
- p.His767Arg Single submitter ⚠
- p.Ile153Val Single submitter
- p.Ile162Val Single submitter ⚠
- p.Ile263Val Single submitter ⚠
- p.Ile320Thr Single submitter ⚠
- p.Ile539Met Single submitter ⚠
- p.Ile629Val Single submitter ⚠
- p.Ile747Asn Single submitter ⚠
- p.Ile861Val Single submitter ⚠
- p.Leu126Val Single submitter ⚠
- p.Leu27Arg Single submitter
- p.Leu668Met Single submitter ⚠
- p.Lys210Glu Single submitter ⚠
- p.Lys328Gln Single submitter ⚠
- p.Met295Thr Single submitter ⚠
- p.Met330Val Single submitter ⚠
- p.Met351Thr Single submitter ⚠
- p.Met428Thr Single submitter ⚠
- p.Met499Ile Single submitter ⚠
- p.Met694Leu Single submitter ⚠
- p.Met694Val Single submitter
- p.Met855Val Single submitter ⚠
- p.Phe117Leu Single submitter ⚠
- p.Pro403Leu Single submitter ⚠
- p.Pro426Leu Single submitter ⚠
- p.Pro438Leu Single submitter ⚠
- p.Pro578Ala Single submitter ⚠
- p.Pro631Ala Single submitter ⚠
- p.Pro631Thr Single submitter ⚠
- p.Pro702Leu Single submitter ⚠
- p.Pro797Arg Single submitter ⚠
- p.Ser14Asn Single submitter ⚠
- p.Ser239Cys Single submitter ⚠
- p.Ser239Phe Single submitter ⚠
- p.Ser442Cys Single submitter ⚠
- p.Ser466Pro Single submitter ⚠
- p.Ser656Leu Single submitter ⚠
- p.Ser717Cys Single submitter ⚠
- p.Ser774Thr Single submitter ⚠
- p.Thr336Met Single submitter ⚠
- p.Thr385Ile Single submitter ⚠
- p.Thr520Arg Single submitter ⚠
- p.Thr520Met Single submitter ⚠
- p.Thr753Met Single submitter
- p.Trp182Arg Single submitter ⚠
- p.Tyr174Cys Single submitter ⚠
- p.Tyr271Phe Single submitter ⚠
- p.Tyr346Ser Single submitter ⚠
- p.Val412Leu Single submitter ⚠
- p.Val412Met Single submitter ⚠
- p.Val477Met Single submitter ⚠
- p.Val733Ile Single submitter ⚠