USP16 — 105 ClinVar variants
All ClinVar germline USP16 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 101 flagged for review →
2 Benign · 1 Likely benign · 102 Uncertain significance
Full USP16 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 101
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 89
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP16 p.Ala584Pro Uncertain significance Single submitter
- USP16 p.Ala768Thr Uncertain significance Single submitter
- USP16 p.Arg357Cys Uncertain significance Single submitter
- USP16 p.Arg455Leu Uncertain significance Single submitter
- USP16 p.Arg642Cys Uncertain significance Single submitter
- USP16 p.Arg659Gln Uncertain significance Single submitter
- USP16 p.Arg708His Uncertain significance Single submitter
- USP16 p.Arg739Thr Uncertain significance Single submitter
- USP16 p.Asn266Tyr Uncertain significance Single submitter
- USP16 p.Asn403Tyr Uncertain significance Single submitter
- USP16 p.Asn567Ser Uncertain significance Single submitter
- USP16 p.Asn580Ser Uncertain significance Single submitter
- USP16 p.Asn706His Uncertain significance Single submitter
- USP16 p.Asp14Tyr Uncertain significance Single submitter
- USP16 p.Asp240Val Uncertain significance Single submitter
- USP16 p.Asp344Gly Uncertain significance Single submitter
- USP16 p.Asp514Tyr Uncertain significance Single submitter
- USP16 p.Asp54Glu Uncertain significance Single submitter
- USP16 p.Asp597Gly Uncertain significance Single submitter
- USP16 p.Cys24Ser Uncertain significance Single submitter
- USP16 p.Gln297Arg Uncertain significance Single submitter
- USP16 p.Gln518Glu Uncertain significance Single submitter
- USP16 p.Gln518Lys Uncertain significance Single submitter
- USP16 p.Gln783Arg Uncertain significance Single submitter
- USP16 p.Glu337Asp Uncertain significance Single submitter
- USP16 p.Glu417Lys Uncertain significance Single submitter
- USP16 p.Glu533Lys Uncertain significance Single submitter
- USP16 p.Glu593Gly Uncertain significance Single submitter
- USP16 p.Glu672Lys Uncertain significance Single submitter
- USP16 p.Glu735Gly Uncertain significance Single submitter
- USP16 p.Glu788Gln Uncertain significance Single submitter
- USP16 p.Gly328Ala Uncertain significance Single submitter
- USP16 p.Gly360Asp Uncertain significance Single submitter
- USP16 p.Gly395Asp Uncertain significance Single submitter
- USP16 p.Gly462Arg Uncertain significance Single submitter
- USP16 p.Gly704Ser Uncertain significance Single submitter
- USP16 p.Gly81Ser Uncertain significance Single submitter
- USP16 p.Gly83Ser Uncertain significance Single submitter
- USP16 p.Gly8Glu Uncertain significance Single submitter
- USP16 p.His103Tyr Uncertain significance Single submitter
- USP16 p.His466Asn Uncertain significance Single submitter
- USP16 p.His497Arg Uncertain significance Single submitter
- USP16 p.His505Arg Uncertain significance Single submitter
- USP16 p.His586Tyr Uncertain significance Single submitter
- USP16 p.His713Gln Uncertain significance Single submitter
- USP16 p.His94Arg Uncertain significance Single submitter
- USP16 p.Ile470Val Uncertain significance Single submitter
- USP16 p.Ile498Thr Uncertain significance Single submitter
- USP16 p.Ile592Arg Uncertain significance Single submitter
- USP16 p.Ile781Thr Uncertain significance Single submitter
- USP16 p.Leu220Pro Uncertain significance Single submitter
- USP16 p.Lys148Gln Uncertain significance Single submitter
- USP16 p.Lys163Ile Uncertain significance Single submitter
- USP16 p.Lys463Thr Uncertain significance Single submitter
- USP16 p.Lys506Glu Uncertain significance Single submitter
- USP16 p.Lys530Asn Uncertain significance Single submitter
- USP16 p.Lys645Glu Uncertain significance Single submitter
- USP16 p.Met180Val Uncertain significance Single submitter
- USP16 p.Met504Val Uncertain significance Single submitter
- USP16 p.Met542Ile Uncertain significance Single submitter
- USP16 p.Phe626Ser Uncertain significance Single submitter
- USP16 p.Pro147Ser Uncertain significance Single submitter
- USP16 p.Pro186Leu Uncertain significance Single submitter
- USP16 p.Pro238Leu Uncertain significance Single submitter
- USP16 p.Pro254Ala Uncertain significance Single submitter
- USP16 p.Pro278Leu Uncertain significance Single submitter
- USP16 p.Pro388Leu Uncertain significance Single submitter
- USP16 p.Pro69Ala Uncertain significance Single submitter
- USP16 p.Ser168Asn Uncertain significance Single submitter
- USP16 p.Ser17Ala Uncertain significance Single submitter
- USP16 p.Ser353Cys Uncertain significance Single submitter
- USP16 p.Ser551Ala Uncertain significance Single submitter
- USP16 p.Ser598Gly Uncertain significance Single submitter
- USP16 p.Ser756Leu Uncertain significance Single submitter
- USP16 p.Ser812Ala Uncertain significance Single submitter
- USP16 p.Thr146Ala Uncertain significance Single submitter
- USP16 p.Thr194Ala Uncertain significance Single submitter
- USP16 p.Thr532Pro Uncertain significance Single submitter
- USP16 p.Thr550Lys Uncertain significance Single submitter
- USP16 p.Thr65Ala Uncertain significance Single submitter
- USP16 p.Tyr508Cys Uncertain significance Single submitter
- USP16 p.Tyr638Cys Uncertain significance Single submitter
- USP16 p.Tyr742His Uncertain significance Single submitter
- USP16 p.Tyr762Cys Uncertain significance Single submitter
- USP16 p.Val399Leu Uncertain significance Single submitter
- USP16 p.Val525Ile Uncertain significance Single submitter
- USP16 p.Val57Met Uncertain significance Single submitter
- USP16 p.Val656Ile Uncertain significance Single submitter
- USP16 p.Val804Glu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- USP16 p.Ala91Gly Uncertain significance Single submitter
- USP16 p.Arg305His Uncertain significance Single submitter
- USP16 p.Arg739Gly Uncertain significance Single submitter
- USP16 p.Arg99Thr Uncertain significance Single submitter
- USP16 p.Gln683Lys Uncertain significance Single submitter
- USP16 p.Glu252Gly Uncertain significance Single submitter
- USP16 p.Gly322Arg Uncertain significance Single submitter
- USP16 p.Leu201Met Uncertain significance Single submitter
- USP16 p.Leu777Pro Uncertain significance Single submitter
- USP16 p.Lys808Glu Uncertain significance Single submitter
- USP16 p.Thr658Ile Uncertain significance Single submitter
- USP16 p.Tyr295Cys Uncertain significance Single submitter
All USP16 variants
Benign 2
- c.2011+9A>G Multiple submitters
- p.Leu251= Single submitter
Likely benign 1
- p.Asn574Ser Single submitter
Uncertain significance 102
- p.Ala584Pro Single submitter ⚠
- p.Ala768Thr Single submitter ⚠
- p.Ala91Gly Single submitter ⚠
- p.Arg305His Single submitter ⚠
- p.Arg357Cys Single submitter ⚠
- p.Arg455Leu Single submitter ⚠
- p.Arg642Cys Single submitter ⚠
- p.Arg659Gln Single submitter ⚠
- p.Arg708His Single submitter ⚠
- p.Arg739Gly Single submitter ⚠
- p.Arg739Thr Single submitter ⚠
- p.Arg99Thr Single submitter ⚠
- p.Asn266Tyr Single submitter ⚠
- p.Asn403Tyr Single submitter ⚠
- p.Asn567Ser Single submitter ⚠
- p.Asn580Ser Single submitter ⚠
- p.Asn706His Single submitter ⚠
- p.Asp14Tyr Single submitter ⚠
- p.Asp240Val Single submitter ⚠
- p.Asp344Gly Single submitter ⚠
- p.Asp514Tyr Single submitter ⚠
- p.Asp54Glu Single submitter ⚠
- p.Asp597Gly Single submitter ⚠
- p.Cys24Ser Single submitter ⚠
- p.Gln297Arg Single submitter ⚠
- p.Gln518Glu Single submitter ⚠
- p.Gln518Lys Single submitter ⚠
- p.Gln683Lys Single submitter ⚠
- p.Gln783Arg Single submitter ⚠
- p.Glu252Gly Single submitter ⚠
- p.Glu337Asp Single submitter ⚠
- p.Glu417Lys Single submitter ⚠
- p.Glu533Lys Single submitter ⚠
- p.Glu593Gly Single submitter ⚠
- p.Glu672Lys Single submitter ⚠
- p.Glu735Gly Single submitter ⚠
- p.Glu788Gln Single submitter ⚠
- p.Gly322Arg Single submitter ⚠
- p.Gly328Ala Single submitter ⚠
- p.Gly360Asp Single submitter ⚠
- p.Gly395Asp Single submitter ⚠
- p.Gly462Arg Single submitter ⚠
- p.Gly704Ser Single submitter ⚠
- p.Gly81Ser Single submitter ⚠
- p.Gly83Ser Single submitter ⚠
- p.Gly8Glu Single submitter ⚠
- p.His103Tyr Single submitter ⚠
- p.His466Asn Single submitter ⚠
- p.His497Arg Single submitter ⚠
- p.His505Arg Single submitter ⚠
- p.His586Tyr Single submitter ⚠
- p.His713Gln Single submitter ⚠
- p.His94Arg Single submitter ⚠
- p.Ile470Val Single submitter ⚠
- p.Ile498Thr Single submitter ⚠
- p.Ile592Arg Single submitter ⚠
- p.Ile781Thr Single submitter ⚠
- p.Leu201Met Single submitter ⚠
- p.Leu220Pro Single submitter ⚠
- p.Leu777Pro Single submitter ⚠
- p.Lys148Gln Single submitter ⚠
- p.Lys163Ile Single submitter ⚠
- p.Lys463Thr Single submitter ⚠
- p.Lys506Glu Single submitter ⚠
- p.Lys530Asn Single submitter ⚠
- p.Lys645Glu Single submitter ⚠
- p.Lys808Glu Single submitter ⚠
- p.Met180Val Single submitter ⚠
- p.Met368Thr Single submitter
- p.Met504Val Single submitter ⚠
- p.Met542Ile Single submitter ⚠
- p.Phe626Ser Single submitter ⚠
- p.Pro147Ser Single submitter ⚠
- p.Pro186Leu Single submitter ⚠
- p.Pro238Leu Single submitter ⚠
- p.Pro254Ala Single submitter ⚠
- p.Pro278Leu Single submitter ⚠
- p.Pro388Leu Single submitter ⚠
- p.Pro69Ala Single submitter ⚠
- p.Ser168Asn Single submitter ⚠
- p.Ser17Ala Single submitter ⚠
- p.Ser353Cys Single submitter ⚠
- p.Ser551Ala Single submitter ⚠
- p.Ser598Gly Single submitter ⚠
- p.Ser756Leu Single submitter ⚠
- p.Ser812Ala Single submitter ⚠
- p.Thr146Ala Single submitter ⚠
- p.Thr194Ala Single submitter ⚠
- p.Thr532Pro Single submitter ⚠
- p.Thr550Lys Single submitter ⚠
- p.Thr658Ile Single submitter ⚠
- p.Thr65Ala Single submitter ⚠
- p.Tyr295Cys Single submitter ⚠
- p.Tyr508Cys Single submitter ⚠
- p.Tyr638Cys Single submitter ⚠
- p.Tyr742His Single submitter ⚠
- p.Tyr762Cys Single submitter ⚠
- p.Val399Leu Single submitter ⚠
- p.Val525Ile Single submitter ⚠
- p.Val57Met Single submitter ⚠
- p.Val656Ile Single submitter ⚠
- p.Val804Glu Single submitter ⚠