USP2 — 86 ClinVar variants
All ClinVar germline USP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
3 Benign · 6 Likely benign · 77 Uncertain significance
Full USP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP2 p.Ala15Thr Uncertain significance Single submitter
- USP2 p.Ala244Thr Uncertain significance Single submitter
- USP2 p.Arg10His Uncertain significance Single submitter
- USP2 p.Arg148Trp Uncertain significance Single submitter
- USP2 p.Arg160Gln Uncertain significance Single submitter
- USP2 p.Arg168His Uncertain significance Single submitter
- USP2 p.Arg16Cys Uncertain significance Single submitter
- USP2 p.Arg174Trp Uncertain significance Single submitter
- USP2 p.Arg204Cys Uncertain significance Single submitter
- USP2 p.Arg204His Uncertain significance Single submitter
- USP2 p.Arg233His Uncertain significance Single submitter
- USP2 p.Arg249Cys Uncertain significance Single submitter
- USP2 p.Arg249His Uncertain significance Single submitter
- USP2 p.Arg292Lys Uncertain significance Single submitter
- USP2 p.Arg480Gln Uncertain significance Single submitter
- USP2 p.Arg509Lys Uncertain significance Single submitter
- USP2 p.Arg62Cys Uncertain significance Single submitter
- USP2 p.Arg62His Uncertain significance Single submitter
- USP2 p.Arg76Trp Uncertain significance Single submitter
- USP2 p.Arg91Trp Uncertain significance Single submitter
- USP2 p.Asn165Lys Uncertain significance Single submitter
- USP2 p.Asn38Thr Uncertain significance Single submitter
- USP2 p.Asn535Asp Uncertain significance Single submitter
- USP2 p.Asn574His Uncertain significance Single submitter
- USP2 p.Asp149Tyr Uncertain significance Single submitter
- USP2 p.Asp367Gly Uncertain significance Single submitter
- USP2 p.Asp84Asn Uncertain significance Single submitter
- USP2 p.Cys485Ser Uncertain significance Single submitter
- USP2 p.Glu372Lys Uncertain significance Single submitter
- USP2 p.Gly106Cys Uncertain significance Single submitter
- USP2 p.Gly110Asp Uncertain significance Single submitter
- USP2 p.Gly112Glu Uncertain significance Single submitter
- USP2 p.Gly116Arg Uncertain significance Single submitter
- USP2 p.Gly184Arg Uncertain significance Single submitter
- USP2 p.Gly265Ala Uncertain significance Single submitter
- USP2 p.His306Tyr Uncertain significance Single submitter
- USP2 p.His571Tyr Uncertain significance Single submitter
- USP2 p.Leu122Pro Uncertain significance Single submitter
- USP2 p.Leu185Phe Uncertain significance Single submitter
- USP2 p.Leu199Gln Uncertain significance Single submitter
- USP2 p.Lys177Arg Uncertain significance Single submitter
- USP2 p.Lys320Glu Uncertain significance Single submitter
- USP2 p.Met171Arg Uncertain significance Single submitter
- USP2 p.Met301Leu Uncertain significance Single submitter
- USP2 p.Met554Ile Uncertain significance Single submitter
- USP2 p.Met581Val Uncertain significance Single submitter
- USP2 p.Phe573Tyr Uncertain significance Single submitter
- USP2 p.Pro253Leu Uncertain significance Single submitter
- USP2 p.Pro348Leu Uncertain significance Single submitter
- USP2 p.Ser123Gly Uncertain significance Single submitter
- USP2 p.Ser14Leu Uncertain significance Single submitter
- USP2 p.Ser262Arg Uncertain significance Single submitter
- USP2 p.Thr175Met Uncertain significance Single submitter
- USP2 p.Thr235Met Uncertain significance Single submitter
- USP2 p.Thr239Met Uncertain significance Single submitter
- USP2 p.Thr579Ala Uncertain significance Single submitter
- USP2 p.Thr65Ser Uncertain significance Single submitter
- USP2 p.Thr96Pro Uncertain significance Single submitter
- USP2 p.Tyr186Ser Uncertain significance Single submitter
- USP2 p.Tyr294Phe Uncertain significance Single submitter
- USP2 p.Tyr544Phe Uncertain significance Single submitter
- USP2 p.Val117Met Uncertain significance Single submitter
- USP2 p.Val211Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- USP2 p.Arg375Gln Uncertain significance Single submitter
- USP2 p.Arg484Gln Uncertain significance Single submitter
- USP2 p.Arg563Cys Uncertain significance Single submitter
- USP2 p.Asp590Tyr Uncertain significance Single submitter
- USP2 p.Glu530Lys Uncertain significance Single submitter
- USP2 p.Leu390Pro Uncertain significance Single submitter
- USP2 p.Met581Lys Uncertain significance Single submitter
- USP2 p.Pro348Ser Uncertain significance Single submitter
- USP2 p.Ser490Phe Uncertain significance Single submitter
- USP2 p.Ser577Gly Uncertain significance Single submitter
- USP2 p.Val376Leu Uncertain significance Single submitter
- USP2 p.Val578Ile Uncertain significance Single submitter
All USP2 variants
Benign 3
- p.Glu93= Multiple submitters
- p.Arg78= Single submitter
- p.Pro230Leu Single submitter
Likely benign 6
- p.Ala215Thr Single submitter
- p.Ala29Thr Single submitter
- p.Gly257Ser Single submitter
- p.Ile224Leu Single submitter
- p.Pro53Leu Single submitter
- p.Val315Met Single submitter
Uncertain significance 77
- p.Ala15Thr Single submitter ⚠
- p.Ala244Thr Single submitter ⚠
- p.Arg10His Single submitter ⚠
- p.Arg148Trp Single submitter ⚠
- p.Arg160Gln Single submitter ⚠
- p.Arg168His Single submitter ⚠
- p.Arg16Cys Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg204Cys Single submitter ⚠
- p.Arg204His Single submitter ⚠
- p.Arg233His Single submitter ⚠
- p.Arg249Cys Single submitter ⚠
- p.Arg249His Single submitter ⚠
- p.Arg292Lys Single submitter ⚠
- p.Arg375Gln Single submitter ⚠
- p.Arg480Gln Single submitter ⚠
- p.Arg484Gln Single submitter ⚠
- p.Arg509Lys Single submitter ⚠
- p.Arg563Cys Single submitter ⚠
- p.Arg604Pro Single submitter
- p.Arg62Cys Single submitter ⚠
- p.Arg62His Single submitter ⚠
- p.Arg76Trp Single submitter ⚠
- p.Arg91Trp Single submitter ⚠
- p.Asn165Lys Single submitter ⚠
- p.Asn38Thr Single submitter ⚠
- p.Asn535Asp Single submitter ⚠
- p.Asn574His Single submitter ⚠
- p.Asp149Tyr Single submitter ⚠
- p.Asp367Gly Single submitter ⚠
- p.Asp590Tyr Single submitter ⚠
- p.Asp84Asn Single submitter ⚠
- p.Cys485Ser Single submitter ⚠
- p.Glu372Lys Single submitter ⚠
- p.Glu530Lys Single submitter ⚠
- p.Gly106Cys Single submitter ⚠
- p.Gly110Asp Single submitter ⚠
- p.Gly112Glu Single submitter ⚠
- p.Gly116Arg Single submitter ⚠
- p.Gly184Arg Single submitter ⚠
- p.Gly265Ala Single submitter ⚠
- p.His306Tyr Single submitter ⚠
- p.His571Tyr Single submitter ⚠
- p.Leu122Pro Single submitter ⚠
- p.Leu185Phe Single submitter ⚠
- p.Leu199Gln Single submitter ⚠
- p.Leu390Pro Single submitter ⚠
- p.Lys177Arg Single submitter ⚠
- p.Lys320Glu Single submitter ⚠
- p.Met171Arg Single submitter ⚠
- p.Met301Leu Single submitter ⚠
- p.Met554Ile Single submitter ⚠
- p.Met581Lys Single submitter ⚠
- p.Met581Val Single submitter ⚠
- p.Phe573Tyr Single submitter ⚠
- p.Pro253Leu Single submitter ⚠
- p.Pro348Leu Single submitter ⚠
- p.Pro348Ser Single submitter ⚠
- p.Pro522Ser Single submitter
- p.Ser123Gly Single submitter ⚠
- p.Ser14Leu Single submitter ⚠
- p.Ser262Arg Single submitter ⚠
- p.Ser490Phe Single submitter ⚠
- p.Ser577Gly Single submitter ⚠
- p.Thr175Met Single submitter ⚠
- p.Thr235Met Single submitter ⚠
- p.Thr239Met Single submitter ⚠
- p.Thr579Ala Single submitter ⚠
- p.Thr65Ser Single submitter ⚠
- p.Thr96Pro Single submitter ⚠
- p.Tyr186Ser Single submitter ⚠
- p.Tyr294Phe Single submitter ⚠
- p.Tyr544Phe Single submitter ⚠
- p.Val117Met Single submitter ⚠
- p.Val211Leu Single submitter ⚠
- p.Val376Leu Single submitter ⚠
- p.Val578Ile Single submitter ⚠