USP20 — 154 ClinVar variants

All ClinVar germline USP20 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 137 flagged for review →

5 Benign · 4 Likely benign · 145 Uncertain significance

Full USP20 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 137

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 106

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 31

The independent predictors disagree with each other — read with care.

All USP20 variants

Benign 5

p.Ile907= Multiple submitters
p.Pro367= Multiple submitters
p.Ser103Tyr Multiple submitters
p.Ser288= Multiple submitters
p.Ala362= Single submitter

Likely benign 4

p.Ala362Thr Single submitter
p.Ala362Val Single submitter
p.Ser443= Single submitter
p.His10fs No assertion criteria EBV-positive nodal T- and NK-cell lymphoma

Uncertain significance 145

p.Arg330Gly Multiple submitters ⚠
p.Ala260Ser Single submitter ⚠
p.Ala317Thr Single submitter ⚠
p.Ala355Thr Single submitter ⚠
p.Ala502Ser Single submitter ⚠
p.Ala689Ser Single submitter ⚠
p.Ala701Gly Single submitter ⚠
p.Ala724Ser Single submitter ⚠
p.Ala724Val Single submitter ⚠
p.Ala830Val Single submitter ⚠
p.Ala909Pro Single submitter ⚠
p.Ala913Thr Single submitter ⚠
p.Arg272Gln Single submitter ⚠
p.Arg276Trp Single submitter ⚠
p.Arg292Gln Single submitter ⚠
p.Arg300Cys Single submitter ⚠
p.Arg326Gln Single submitter ⚠
p.Arg326Trp Single submitter ⚠
p.Arg338Cys Single submitter ⚠
p.Arg370Gln Single submitter ⚠
p.Arg376Trp Single submitter ⚠
p.Arg387Cys Single submitter ⚠
p.Arg387His Single submitter ⚠
p.Arg391Cys Single submitter ⚠
p.Arg434Trp Single submitter ⚠
p.Arg436Trp Single submitter ⚠
p.Arg440Cys Single submitter ⚠
p.Arg522Trp Single submitter ⚠
p.Arg562Gln Single submitter ⚠
p.Arg562Leu Single submitter ⚠
p.Arg562Trp Single submitter ⚠
p.Arg577Trp Single submitter ⚠
p.Arg691Gln Single submitter ⚠
p.Arg693Gln Single submitter ⚠
p.Arg703Gln Single submitter ⚠
p.Arg709Gln Single submitter ⚠
p.Arg709Trp Single submitter ⚠
p.Arg714His Single submitter
p.Arg793His Single submitter ⚠
p.Arg889Cys Single submitter ⚠
p.Arg912Trp Single submitter ⚠
p.Arg95Gln Single submitter ⚠
p.Arg95Trp Single submitter ⚠
p.Asn653Ser Single submitter ⚠
p.Asn845Ser Single submitter ⚠
p.Asp329Gly Single submitter ⚠
p.Asp6Val Single submitter ⚠
p.Asp750Asn Single submitter ⚠
p.Asp799Asn Single submitter ⚠
p.Cys375Phe Single submitter ⚠
p.Cys393Arg Single submitter ⚠
p.Gln66Glu Single submitter ⚠
p.Glu308Lys Single submitter ⚠
p.Glu676Asp Single submitter ⚠
p.Glu811Lys Single submitter ⚠
p.Glu812Lys Single submitter ⚠
p.Glu87Lys Single submitter ⚠
p.Glu885Lys Single submitter
p.Gly297Arg Single submitter ⚠
p.Gly302Arg Single submitter ⚠
p.Gly37Arg Single submitter ⚠
p.Gly511Ala Single submitter ⚠
p.Gly511Ser Single submitter ⚠
p.Gly534Arg Single submitter ⚠
p.Gly855Ser Single submitter ⚠
p.Gly866Arg Single submitter ⚠
p.Gly903Arg Single submitter ⚠
p.His244Tyr Single submitter ⚠
p.Ile516Val Single submitter ⚠
p.Ile755Asn Single submitter ⚠
p.Ile798Phe Single submitter ⚠
p.Ile843Thr Single submitter ⚠
p.Ile888Val Single submitter ⚠
p.Leu11Ile Single submitter ⚠
p.Leu429Ser Single submitter ⚠
p.Leu539Val Single submitter ⚠
p.Leu566Val Single submitter ⚠
p.Leu582Pro Single submitter ⚠
p.Leu607Val Single submitter ⚠
p.Leu81Arg Single submitter ⚠
p.Leu859Pro Single submitter
p.Leu92Val Single submitter ⚠
p.Lys148Arg Single submitter ⚠
p.Lys404Asn Single submitter ⚠
p.Lys553Asn Single submitter ⚠
p.Lys574Glu Single submitter ⚠
p.Lys69Arg Single submitter ⚠
p.Lys803Arg Single submitter ⚠
p.Lys833Arg Single submitter ⚠
p.Lys852Glu Single submitter ⚠
p.Met147Val Single submitter ⚠
p.Met223Val Single submitter ⚠
p.Met557Ile Single submitter ⚠
p.Met822Arg Single submitter ⚠
p.Phe235Leu Single submitter ⚠
p.Phe659Ile Single submitter ⚠
p.Pro113Leu Single submitter ⚠
p.Pro250Leu Single submitter ⚠
p.Pro367Leu Single submitter ⚠
p.Pro395Ser Single submitter ⚠
p.Pro409Arg Single submitter ⚠
p.Pro410Thr Single submitter ⚠
p.Pro419Leu Single submitter ⚠
p.Pro500Leu Single submitter ⚠
p.Pro705His Single submitter ⚠
p.Pro757Ser Single submitter ⚠
p.Pro99Leu Single submitter ⚠
p.Ser288Leu Single submitter ⚠
p.Ser289Asn Single submitter ⚠
p.Ser305Leu Single submitter ⚠
p.Ser408Arg Single submitter ⚠
p.Ser466Pro Single submitter ⚠
p.Ser526Cys Single submitter ⚠
p.Ser530Gly Single submitter ⚠
p.Ser737Pro Single submitter ⚠
p.Thr170Ser Single submitter
p.Thr211Ile Single submitter ⚠
p.Thr258Met Single submitter ⚠
p.Thr309Met Single submitter ⚠
p.Thr377Ala Single submitter ⚠
p.Thr377Met Single submitter ⚠
p.Thr471Met Single submitter ⚠
p.Thr538Asn Single submitter ⚠
p.Thr538fs Single submitter
p.Thr73Ala Single submitter
p.Thr872Ile Single submitter ⚠
p.Tyr711Cys Single submitter ⚠
p.Tyr765Phe Single submitter ⚠
p.Tyr778Phe Single submitter ⚠
p.Tyr865His Single submitter ⚠
p.Val208Met Single submitter
p.Val220Asp Single submitter ⚠
p.Val396Ile Single submitter ⚠
p.Val415Met Single submitter ⚠
p.Val422Met Single submitter ⚠
p.Val457Leu Single submitter ⚠
p.Val537Ile Single submitter ⚠
p.Val651Met Single submitter ⚠
p.Val664Ile Single submitter ⚠
p.Val712Leu Single submitter ⚠
p.Val74Met Single submitter
p.Val760Ile Single submitter ⚠
p.Val774Met Single submitter ⚠
p.Val90Ile Single submitter ⚠
p.Val914Leu Single submitter ⚠