USP21 — 75 ClinVar variants
All ClinVar germline USP21 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 73 flagged for review →
1 Likely benign · 74 Uncertain significance
Full USP21 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 73
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP21 p.Ala143Val Uncertain significance Single submitter
- USP21 p.Arg105Trp Uncertain significance Single submitter
- USP21 p.Arg110His Uncertain significance Single submitter
- USP21 p.Arg11Cys Uncertain significance Single submitter
- USP21 p.Arg13Gln Uncertain significance Single submitter
- USP21 p.Arg145Gln Uncertain significance Single submitter
- USP21 p.Arg153His Uncertain significance Single submitter
- USP21 p.Arg158His Uncertain significance Single submitter
- USP21 p.Arg173Gln Uncertain significance Single submitter
- USP21 p.Arg173Trp Uncertain significance Single submitter
- USP21 p.Arg189Gln Uncertain significance Single submitter
- USP21 p.Arg189Trp Uncertain significance Single submitter
- USP21 p.Arg282Gln Uncertain significance Single submitter
- USP21 p.Arg312Gln Uncertain significance Single submitter
- USP21 p.Arg320Gln Uncertain significance Single submitter
- USP21 p.Arg322His Uncertain significance Single submitter
- USP21 p.Arg338Cys Uncertain significance Single submitter
- USP21 p.Arg338His Uncertain significance Single submitter
- USP21 p.Arg34His Uncertain significance Single submitter
- USP21 p.Arg354Gln Uncertain significance Single submitter
- USP21 p.Arg365Gln Uncertain significance Single submitter
- USP21 p.Arg38His Uncertain significance Single submitter
- USP21 p.Arg439Gln Uncertain significance Single submitter
- USP21 p.Arg457Gln Uncertain significance Single submitter
- USP21 p.Arg524Gln Uncertain significance Single submitter
- USP21 p.Arg55Gln Uncertain significance Single submitter
- USP21 p.Arg62Gln Uncertain significance Single submitter
- USP21 p.Arg72Gln Uncertain significance Single submitter
- USP21 p.Arg72Trp Uncertain significance Single submitter
- USP21 p.Arg77His Uncertain significance Single submitter
- USP21 p.Arg8Cys Uncertain significance Single submitter
- USP21 p.Arg8His Uncertain significance Single submitter
- USP21 p.Arg8Leu Uncertain significance Single submitter
- USP21 p.Asn509Ser Uncertain significance Single submitter
- USP21 p.Asp481Glu Uncertain significance Single submitter
- USP21 p.Cys381Phe Uncertain significance Single submitter
- USP21 p.Gln559Arg Uncertain significance Single submitter
- USP21 p.Glu14Lys Uncertain significance Single submitter
- USP21 p.Glu37Asp Uncertain significance Single submitter
- USP21 p.Glu430Asp Uncertain significance Single submitter
- USP21 p.Gly162Val Uncertain significance Single submitter
- USP21 p.Gly24Arg Uncertain significance Single submitter
- USP21 p.Gly24Val Uncertain significance Single submitter
- USP21 p.Gly408Ala Uncertain significance Single submitter
- USP21 p.Gly412Ser Uncertain significance Single submitter
- USP21 p.Gly479Val Uncertain significance Single submitter
- USP21 p.Gly87Glu Uncertain significance Single submitter
- USP21 p.Leu144Phe Uncertain significance Single submitter
- USP21 p.Leu52Arg Uncertain significance Single submitter
- USP21 p.Leu52Gln Uncertain significance Single submitter
- USP21 p.Phe163Val Uncertain significance Single submitter
- USP21 p.Pro103Ala Uncertain significance Single submitter
- USP21 p.Pro149Leu Uncertain significance Single submitter
- USP21 p.Pro167Arg Uncertain significance Single submitter
- USP21 p.Pro176Ala Uncertain significance Single submitter
- USP21 p.Pro235Ser Uncertain significance Single submitter
- USP21 p.Pro31Ser Uncertain significance Single submitter
- USP21 p.Pro336Ser Uncertain significance Single submitter
- USP21 p.Pro347Ser Uncertain significance Single submitter
- USP21 p.Pro96Ala Uncertain significance Single submitter
- USP21 p.Ser190Tyr Uncertain significance Single submitter
- USP21 p.Ser232Gly Uncertain significance Single submitter
- USP21 p.Ser35Gly Uncertain significance Single submitter
- USP21 p.Ser431Leu Uncertain significance Single submitter
- USP21 p.Ser476Cys Uncertain significance Single submitter
- USP21 p.Thr73Ile Uncertain significance Single submitter
- USP21 p.Val478Ile Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- USP21 p.Arg145Trp Uncertain significance Single submitter
- USP21 p.Arg361Cys Uncertain significance Single submitter
- USP21 p.Asn533Ser Uncertain significance Single submitter
- USP21 p.Glu395Lys Uncertain significance Single submitter
- USP21 p.Glu6Lys Uncertain significance Single submitter
- USP21 p.Lys360Glu Uncertain significance Single submitter
All USP21 variants
Likely benign 1
- p.Arg536= Single submitter
Uncertain significance 74
- p.Ala143Val Single submitter ⚠
- p.Arg105Trp Single submitter ⚠
- p.Arg110His Single submitter ⚠
- p.Arg11Cys Single submitter ⚠
- p.Arg13Gln Single submitter ⚠
- p.Arg145Gln Single submitter ⚠
- p.Arg145Trp Single submitter ⚠
- p.Arg153His Single submitter ⚠
- p.Arg158His Single submitter ⚠
- p.Arg173Gln Single submitter ⚠
- p.Arg173Trp Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg189Trp Single submitter ⚠
- p.Arg282Gln Single submitter ⚠
- p.Arg312Gln Single submitter ⚠
- p.Arg320Gln Single submitter ⚠
- p.Arg322His Single submitter ⚠
- p.Arg338Cys Single submitter ⚠
- p.Arg338His Single submitter ⚠
- p.Arg34His Single submitter ⚠
- p.Arg354Gln Single submitter ⚠
- p.Arg361Cys Single submitter ⚠
- p.Arg365Gln Single submitter ⚠
- p.Arg38His Single submitter ⚠
- p.Arg439Gln Single submitter ⚠
- p.Arg457Gln Single submitter ⚠
- p.Arg524Gln Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg62Gln Single submitter ⚠
- p.Arg72Gln Single submitter ⚠
- p.Arg72Trp Single submitter ⚠
- p.Arg77His Single submitter ⚠
- p.Arg8Cys Single submitter ⚠
- p.Arg8His Single submitter ⚠
- p.Arg8Leu Single submitter ⚠
- p.Asn509Ser Single submitter ⚠
- p.Asn533Ser Single submitter ⚠
- p.Asp481Glu Single submitter ⚠
- p.Cys381Phe Single submitter ⚠
- p.Gln559Arg Single submitter ⚠
- p.Glu14Lys Single submitter ⚠
- p.Glu37Asp Single submitter ⚠
- p.Glu395Lys Single submitter ⚠
- p.Glu430Asp Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Gly162Val Single submitter ⚠
- p.Gly24Arg Single submitter ⚠
- p.Gly24Val Single submitter ⚠
- p.Gly408Ala Single submitter ⚠
- p.Gly412Ser Single submitter ⚠
- p.Gly479Val Single submitter ⚠
- p.Gly87Glu Single submitter ⚠
- p.Leu144Phe Single submitter ⚠
- p.Leu52Arg Single submitter ⚠
- p.Leu52Gln Single submitter ⚠
- p.Lys360Glu Single submitter ⚠
- p.Phe163Val Single submitter ⚠
- p.Pro103Ala Single submitter ⚠
- p.Pro149Leu Single submitter ⚠
- p.Pro167Arg Single submitter ⚠
- p.Pro176Ala Single submitter ⚠
- p.Pro235Ser Single submitter ⚠
- p.Pro31Ser Single submitter ⚠
- p.Pro336Ser Single submitter ⚠
- p.Pro347Ser Single submitter ⚠
- p.Pro96Ala Single submitter ⚠
- p.Ser190Tyr Single submitter ⚠
- p.Ser232Gly Single submitter ⚠
- p.Ser35Gly Single submitter ⚠
- p.Ser431Leu Single submitter ⚠
- p.Ser476Cys Single submitter ⚠
- p.Ser538Phe Single submitter
- p.Thr73Ile Single submitter ⚠
- p.Val478Ile Single submitter ⚠