USP28 — 121 ClinVar variants
All ClinVar germline USP28 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 111 flagged for review →
1 Benign · 3 Likely benign · 117 Uncertain significance
Full USP28 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 111
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 88
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP28 p.Asp345Asn Uncertain significance Multiple submitters
- USP28 p.Ala104Thr Uncertain significance Single submitter
- USP28 p.Ala132Val Uncertain significance Single submitter
- USP28 p.Ala270Ser Uncertain significance Single submitter
- USP28 p.Ala739Val Uncertain significance Single submitter
- USP28 p.Ala83Ser Uncertain significance Single submitter
- USP28 p.Ala89Thr Uncertain significance Single submitter
- USP28 p.Ala932Val Uncertain significance Single submitter
- USP28 p.Arg1000Gln Uncertain significance Single submitter
- USP28 p.Arg1094Gly Uncertain significance Single submitter
- USP28 p.Arg136Cys Uncertain significance Single submitter
- USP28 p.Arg204Gln Uncertain significance Single submitter
- USP28 p.Arg519Gln Uncertain significance Single submitter
- USP28 p.Arg610Gln Uncertain significance Single submitter
- USP28 p.Arg687Gln Uncertain significance Single submitter
- USP28 p.Arg755Cys Uncertain significance Single submitter
- USP28 p.Arg906Gly Uncertain significance Single submitter
- USP28 p.Asn152Ser Uncertain significance Single submitter
- USP28 p.Asn198His Uncertain significance Single submitter
- USP28 p.Asn597Thr Uncertain significance Single submitter
- USP28 p.Asn943Ser Uncertain significance Single submitter
- USP28 p.Asp101Tyr Uncertain significance Single submitter
- USP28 p.Asp338Asn Uncertain significance Single submitter
- USP28 p.Asp650Gly Uncertain significance Single submitter
- USP28 p.Cys1087Tyr Uncertain significance Single submitter
- USP28 p.Cys142Ser Uncertain significance Single submitter
- USP28 p.Cys329Arg Uncertain significance Single submitter
- USP28 p.Gln216Arg Uncertain significance Single submitter
- USP28 p.Gln424Glu Uncertain significance Single submitter
- USP28 p.Gln572His Uncertain significance Single submitter
- USP28 p.Gln682Arg Uncertain significance Single submitter
- USP28 p.Gln68Glu Uncertain significance Single submitter
- USP28 p.Gln690Arg Uncertain significance Single submitter
- USP28 p.Glu1090Gln Uncertain significance Single submitter
- USP28 p.Glu208Ala Uncertain significance Single submitter
- USP28 p.Glu537Lys Uncertain significance Single submitter
- USP28 p.Glu722Asp Uncertain significance Single submitter
- USP28 p.Glu722Gly Uncertain significance Single submitter
- USP28 p.Gly159Asp Uncertain significance Single submitter
- USP28 p.Gly159Ser Uncertain significance Single submitter
- USP28 p.Gly294Asp Uncertain significance Single submitter
- USP28 p.His468Asn Uncertain significance Single submitter
- USP28 p.His738Tyr Uncertain significance Single submitter
- USP28 p.Ile31Met Uncertain significance Single submitter
- USP28 p.Ile421Met Uncertain significance Single submitter
- USP28 p.Ile556Thr Uncertain significance Single submitter
- USP28 p.Ile570Val Uncertain significance Single submitter
- USP28 p.Ile924Val Uncertain significance Single submitter
- USP28 p.Ile92Val Uncertain significance Single submitter
- USP28 p.Leu1105Phe Uncertain significance Single submitter
- USP28 p.Leu970Val Uncertain significance Single submitter
- USP28 p.Lys1003Ile Uncertain significance Single submitter
- USP28 p.Lys209Glu Uncertain significance Single submitter
- USP28 p.Lys349Asn Uncertain significance Single submitter
- USP28 p.Lys408Arg Uncertain significance Single submitter
- USP28 p.Lys759Asn Uncertain significance Single submitter
- USP28 p.Met1041Val Uncertain significance Single submitter
- USP28 p.Met213Ile Uncertain significance Single submitter
- USP28 p.Met444Val Uncertain significance Single submitter
- USP28 p.Met469Ile Uncertain significance Single submitter
- USP28 p.Met469Thr Uncertain significance Single submitter
- USP28 p.Met522Val Uncertain significance Single submitter
- USP28 p.Met573Ile Uncertain significance Single submitter
- USP28 p.Met667Ile Uncertain significance Single submitter
- USP28 p.Met667Thr Uncertain significance Single submitter
- USP28 p.Met995Ile Uncertain significance Single submitter
- USP28 p.Pro37Ser Uncertain significance Single submitter
- USP28 p.Pro440Leu Uncertain significance Single submitter
- USP28 p.Pro577Ala Uncertain significance Single submitter
- USP28 p.Pro879Ser Uncertain significance Single submitter
- USP28 p.Ser1058Cys Uncertain significance Single submitter
- USP28 p.Ser490Thr Uncertain significance Single submitter
- USP28 p.Ser504Phe Uncertain significance Single submitter
- USP28 p.Ser612Gly Uncertain significance Single submitter
- USP28 p.Ser700Phe Uncertain significance Single submitter
- USP28 p.Thr207Ala Uncertain significance Single submitter
- USP28 p.Thr491Ile Uncertain significance Single submitter
- USP28 p.Thr662Ala Uncertain significance Single submitter
- USP28 p.Thr73Ala Uncertain significance Single submitter
- USP28 p.Thr73Arg Uncertain significance Single submitter
- USP28 p.Thr73Ile Uncertain significance Single submitter
- USP28 p.Tyr872Phe Uncertain significance Single submitter
- USP28 p.Val1006Met Uncertain significance Single submitter
- USP28 p.Val1104Ile Uncertain significance Single submitter
- USP28 p.Val362Leu Uncertain significance Single submitter
- USP28 p.Val670Ala Uncertain significance Single submitter
- USP28 p.Val675Met Uncertain significance Single submitter
- USP28 p.Val831Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- USP28 p.Ala986Thr Uncertain significance Single submitter
- USP28 p.Arg1000Trp Uncertain significance Single submitter
- USP28 p.Arg1011Gln Uncertain significance Single submitter
- USP28 p.Arg755Pro Uncertain significance Single submitter
- USP28 p.Gln352Arg Uncertain significance Single submitter
- USP28 p.Glu450Asp Uncertain significance Single submitter
- USP28 p.Gly997Arg Uncertain significance Single submitter
- USP28 p.Ile861Ser Uncertain significance Single submitter
- USP28 p.Leu1096Ile Uncertain significance Single submitter
- USP28 p.Leu242Phe Uncertain significance Single submitter
- USP28 p.Leu263Ile Uncertain significance Single submitter
- USP28 p.Lys408Thr Uncertain significance Single submitter
- USP28 p.Met837Leu Uncertain significance Single submitter
- USP28 p.Phe232Leu Uncertain significance Single submitter
- USP28 p.Phe232Ser Uncertain significance Single submitter
- USP28 p.Phe957Leu Uncertain significance Single submitter
- USP28 p.Pro1109Thr Uncertain significance Single submitter
- USP28 p.Pro885Leu Uncertain significance Single submitter
- USP28 p.Ser641Asn Uncertain significance Single submitter
- USP28 p.Ser856Phe Uncertain significance Single submitter
- USP28 p.Thr534Pro Uncertain significance Single submitter
- USP28 p.Tyr1010Cys Uncertain significance Single submitter
- USP28 p.Tyr606Cys Uncertain significance Single submitter
All USP28 variants
Benign 1
- p.Val1034= Single submitter
Likely benign 3
- p.Arg755His Single submitter
- p.Asn407Ser Single submitter
- p.Leu341= Single submitter
Uncertain significance 117
- p.Asp345Asn Multiple submitters ⚠
- p.Ala104Thr Single submitter ⚠
- p.Ala132Val Single submitter ⚠
- p.Ala270Ser Single submitter ⚠
- p.Ala739Val Single submitter ⚠
- p.Ala83Ser Single submitter ⚠
- p.Ala89Thr Single submitter ⚠
- p.Ala932Val Single submitter ⚠
- p.Ala986Thr Single submitter ⚠
- p.Arg1000Gln Single submitter ⚠
- p.Arg1000Trp Single submitter ⚠
- p.Arg1011Gln Single submitter ⚠
- p.Arg1094Gly Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg204Gln Single submitter ⚠
- p.Arg519Gln Single submitter ⚠
- p.Arg610Gln Single submitter ⚠
- p.Arg687Gln Single submitter ⚠
- p.Arg755Cys Single submitter ⚠
- p.Arg755Pro Single submitter ⚠
- p.Arg906Gly Single submitter ⚠
- p.Asn152Ser Single submitter ⚠
- p.Asn169Ser Single submitter
- p.Asn198His Single submitter ⚠
- p.Asn597Thr Single submitter ⚠
- p.Asn943Ser Single submitter ⚠
- p.Asp101Tyr Single submitter ⚠
- p.Asp338Asn Single submitter ⚠
- p.Asp50Tyr Single submitter
- p.Asp632fs Single submitter
- p.Asp650Gly Single submitter ⚠
- p.Cys1087Tyr Single submitter ⚠
- p.Cys142Ser Single submitter ⚠
- p.Cys329Arg Single submitter ⚠
- p.Gln216Arg Single submitter ⚠
- p.Gln352Arg Single submitter ⚠
- p.Gln424Glu Single submitter ⚠
- p.Gln572His Single submitter ⚠
- p.Gln682Arg Single submitter ⚠
- p.Gln68Glu Single submitter ⚠
- p.Gln690Arg Single submitter ⚠
- p.Glu1090Gln Single submitter ⚠
- p.Glu208Ala Single submitter ⚠
- p.Glu450Asp Single submitter ⚠
- p.Glu537Lys Single submitter ⚠
- p.Glu722Asp Single submitter ⚠
- p.Glu722Gly Single submitter ⚠
- p.Gly159Asp Single submitter ⚠
- p.Gly159Ser Single submitter ⚠
- p.Gly294Asp Single submitter ⚠
- p.Gly997Arg Single submitter ⚠
- p.His468Asn Single submitter ⚠
- p.His738Tyr Single submitter ⚠
- p.Ile31Met Single submitter ⚠
- p.Ile421Met Single submitter ⚠
- p.Ile556Thr Single submitter ⚠
- p.Ile570Val Single submitter ⚠
- p.Ile844Met Single submitter
- p.Ile861Ser Single submitter ⚠
- p.Ile924Val Single submitter ⚠
- p.Ile92Val Single submitter ⚠
- p.Leu1096Ile Single submitter ⚠
- p.Leu1105Phe Single submitter ⚠
- p.Leu242Phe Single submitter ⚠
- p.Leu263Ile Single submitter ⚠
- p.Leu970Val Single submitter ⚠
- p.Lys1003Ile Single submitter ⚠
- p.Lys209Glu Single submitter ⚠
- p.Lys349Asn Single submitter ⚠
- p.Lys408Arg Single submitter ⚠
- p.Lys408Thr Single submitter ⚠
- p.Lys759Asn Single submitter ⚠
- p.Met1041Val Single submitter ⚠
- p.Met213Ile Single submitter ⚠
- p.Met444Val Single submitter ⚠
- p.Met469Ile Single submitter ⚠
- p.Met469Thr Single submitter ⚠
- p.Met522Val Single submitter ⚠
- p.Met573Ile Single submitter ⚠
- p.Met667Ile Single submitter ⚠
- p.Met667Thr Single submitter ⚠
- p.Met837Leu Single submitter ⚠
- p.Met837Val Single submitter
- p.Met995Ile Single submitter ⚠
- p.Phe232Leu Single submitter ⚠
- p.Phe232Ser Single submitter ⚠
- p.Phe957Leu Single submitter ⚠
- p.Pro1109Thr Single submitter ⚠
- p.Pro37Ser Single submitter ⚠
- p.Pro440Leu Single submitter ⚠
- p.Pro577Ala Single submitter ⚠
- p.Pro879Ser Single submitter ⚠
- p.Pro885Leu Single submitter ⚠
- p.Ser1058Cys Single submitter ⚠
- p.Ser490Thr Single submitter ⚠
- p.Ser504Phe Single submitter ⚠
- p.Ser612Gly Single submitter ⚠
- p.Ser641Asn Single submitter ⚠
- p.Ser700Phe Single submitter ⚠
- p.Ser856Phe Single submitter ⚠
- p.Thr207Ala Single submitter ⚠
- p.Thr491Ile Single submitter ⚠
- p.Thr534Pro Single submitter ⚠
- p.Thr662Ala Single submitter ⚠
- p.Thr73Ala Single submitter ⚠
- p.Thr73Arg Single submitter ⚠
- p.Thr73Ile Single submitter ⚠
- p.Tyr1010Cys Single submitter ⚠
- p.Tyr606Cys Single submitter ⚠
- p.Tyr872Phe Single submitter ⚠
- p.Val1006Met Single submitter ⚠
- p.Val1104Ile Single submitter ⚠
- p.Val362Leu Single submitter ⚠
- p.Val670Ala Single submitter ⚠
- p.Val675Met Single submitter ⚠
- p.Val831Met Single submitter ⚠
- p.Leu191Phe No assertion criteria prostate cancer