USP3 — 50 ClinVar variants
All ClinVar germline USP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Benign · 48 Uncertain significance
Full USP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP3 p.Ala306Glu Uncertain significance Single submitter
- USP3 p.Ala64Thr Uncertain significance Single submitter
- USP3 p.Arg204Trp Uncertain significance Single submitter
- USP3 p.Arg352Cys Uncertain significance Single submitter
- USP3 p.Arg365Gln Uncertain significance Single submitter
- USP3 p.Arg97Cys Uncertain significance Single submitter
- USP3 p.Arg97Leu Uncertain significance Single submitter
- USP3 p.Asn21Ser Uncertain significance Single submitter
- USP3 p.Asn281Thr Uncertain significance Single submitter
- USP3 p.Asp213Gly Uncertain significance Single submitter
- USP3 p.Asp99Val Uncertain significance Single submitter
- USP3 p.Cys439Arg Uncertain significance Single submitter
- USP3 p.Glu291Lys Uncertain significance Single submitter
- USP3 p.Glu450Gly Uncertain significance Single submitter
- USP3 p.Gly279Ser Uncertain significance Single submitter
- USP3 p.Gly282Ala Uncertain significance Single submitter
- USP3 p.Gly282Ser Uncertain significance Single submitter
- USP3 p.Gly466Arg Uncertain significance Single submitter
- USP3 p.Ile288Val Uncertain significance Single submitter
- USP3 p.Ile313Val Uncertain significance Single submitter
- USP3 p.Ile317Val Uncertain significance Single submitter
- USP3 p.Lys18Arg Uncertain significance Single submitter
- USP3 p.Lys73Arg Uncertain significance Single submitter
- USP3 p.Pro14Gln Uncertain significance Single submitter
- USP3 p.Ser152Thr Uncertain significance Single submitter
- USP3 p.Ser346Gly Uncertain significance Single submitter
- USP3 p.Ser447Gly Uncertain significance Single submitter
- USP3 p.Thr235Ala Uncertain significance Single submitter
- USP3 p.Thr69Ser Uncertain significance Single submitter
- USP3 p.Thr93Ala Uncertain significance Single submitter
- USP3 p.Thr93Ile Uncertain significance Single submitter
- USP3 p.Tyr256Cys Uncertain significance Single submitter
- USP3 p.Val219Ile Uncertain significance Single submitter
- USP3 p.Val428Ile Uncertain significance Single submitter
-
USP3 p.Phe314Cys
Uncertain significance
No assertion criteria
neutropenia
Predictors split 9
The independent predictors disagree with each other — read with care.
- USP3 p.Arg332Thr Uncertain significance Single submitter
- USP3 p.Arg33Leu Uncertain significance Single submitter
- USP3 p.Asn35Lys Uncertain significance Single submitter
- USP3 p.Cys28Ser Uncertain significance Single submitter
- USP3 p.Glu220Lys Uncertain significance Single submitter
- USP3 p.Leu121Trp Uncertain significance Single submitter
- USP3 p.Met265Thr Uncertain significance Single submitter
- USP3 p.Thr426Ile Uncertain significance Single submitter
- USP3 p.Val424Leu Uncertain significance Single submitter
All USP3 variants
Benign 2
- p.Pro360Thr Multiple submitters
- p.Leu403= Single submitter
Uncertain significance 48
- c.1215+2dup Single submitter
- p.Ala306Glu Single submitter ⚠
- p.Ala64Thr Single submitter ⚠
- p.Arg204Gln Single submitter
- p.Arg204Trp Single submitter ⚠
- p.Arg332Thr Single submitter ⚠
- p.Arg33Leu Single submitter ⚠
- p.Arg352Cys Single submitter ⚠
- p.Arg365Gln Single submitter ⚠
- p.Arg97Cys Single submitter ⚠
- p.Arg97Leu Single submitter ⚠
- p.Asn21Ser Single submitter ⚠
- p.Asn281Thr Single submitter ⚠
- p.Asn35Lys Single submitter ⚠
- p.Asp213Gly Single submitter ⚠
- p.Asp373Asn Single submitter
- p.Asp99Val Single submitter ⚠
- p.Cys28Ser Single submitter ⚠
- p.Cys439Arg Single submitter ⚠
- p.Glu220Lys Single submitter ⚠
- p.Glu291Lys Single submitter ⚠
- p.Glu450Gly Single submitter ⚠
- p.Gly279Ser Single submitter ⚠
- p.Gly282Ala Single submitter ⚠
- p.Gly282Ser Single submitter ⚠
- p.Gly466Arg Single submitter ⚠
- p.Ile288Val Single submitter ⚠
- p.Ile313Val Single submitter ⚠
- p.Ile317Val Single submitter ⚠
- p.Leu121Trp Single submitter ⚠
- p.Lys18Arg Single submitter ⚠
- p.Lys73Arg Single submitter ⚠
- p.Met265Thr Single submitter ⚠
- p.Pro14Gln Single submitter ⚠
- p.Ser152Thr Single submitter ⚠
- p.Ser346Gly Single submitter ⚠
- p.Ser447Gly Single submitter ⚠
- p.Thr235Ala Single submitter ⚠
- p.Thr311Met Single submitter
- p.Thr426Ile Single submitter ⚠
- p.Thr69Ser Single submitter ⚠
- p.Thr93Ala Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Tyr256Cys Single submitter ⚠
- p.Val219Ile Single submitter ⚠
- p.Val424Leu Single submitter ⚠
- p.Val428Ile Single submitter ⚠
- p.Phe314Cys No assertion criteria neutropenia ⚠