USP36 — 178 ClinVar variants

All ClinVar germline USP36 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 141 flagged for review →

1 Conflicting · 10 Benign · 1 Benign/Likely benign · 23 Likely benign · 143 Uncertain significance

Full USP36 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 141

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

USP36 p.Pro712Thr Conflicting Single submitter

Predictors lean, ClinVar uncertain 119

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 21

The independent predictors disagree with each other — read with care.

All USP36 variants

Conflicting classifications of pathogenicity 1

p.Pro712Thr Single submitter ⚠

Benign 10

p.Arg887Pro Multiple submitters
p.Asn1096= Multiple submitters
p.Asp270= Multiple submitters
p.Gly444Ser Multiple submitters
p.Pro346= Multiple submitters
p.Pro443= Multiple submitters
p.Pro479Leu Multiple submitters
p.Thr130Ser Multiple submitters ⚠
p.Thr141= Multiple submitters
p.Thr643= Multiple submitters

Benign/Likely benign 1

p.Phe164= Multiple submitters

Likely benign 23

p.His200Asn Multiple submitters ⚠
p.Ser716= Multiple submitters
p.Ala603Thr Single submitter
p.Ala995Thr Single submitter
p.Arg1006His Single submitter
p.Arg750His Single submitter
p.Arg887Trp Single submitter
p.Asn322= Single submitter
p.Glu789Gly Single submitter
p.Gly438Ala Single submitter
p.Gly609Asp Single submitter
p.Gly842Arg Single submitter
p.Gly942Asp Single submitter
p.His736Arg Single submitter
p.His73Arg Single submitter
p.Lys254= Single submitter
p.Lys847Arg Single submitter
p.Phe545Leu Single submitter
p.Pro542Leu Single submitter
p.Pro654= Single submitter
p.Ser858= Single submitter
p.Thr837= Single submitter
p.Val271= Single submitter

Uncertain significance 143

p.Ala198Thr Single submitter ⚠
p.Ala19Ser Single submitter ⚠
p.Ala279Val Single submitter ⚠
p.Ala540Ser Single submitter ⚠
p.Ala626Val Single submitter ⚠
p.Ala648Thr Single submitter ⚠
p.Ala648Val Single submitter ⚠
p.Ala910Thr Single submitter ⚠
p.Ala981Thr Single submitter ⚠
p.Ala981Val Single submitter ⚠
p.Ala995Ser Single submitter ⚠
p.Ala99Thr Single submitter ⚠
p.Arg1021Gln Single submitter ⚠
p.Arg1064Trp Single submitter ⚠
p.Arg1092Ser Single submitter ⚠
p.Arg1122Cys Single submitter ⚠
p.Arg1123Cys Single submitter ⚠
p.Arg119His Single submitter ⚠
p.Arg157His Single submitter ⚠
p.Arg15Cys Single submitter
p.Arg202His Single submitter ⚠
p.Arg276Gln Single submitter ⚠
p.Arg314Cys Single submitter
p.Arg445Cys Single submitter ⚠
p.Arg445His Single submitter ⚠
p.Arg548Thr Single submitter ⚠
p.Arg607Gly Single submitter ⚠
p.Arg775Trp Single submitter ⚠
p.Arg851Cys Single submitter ⚠
p.Arg935Gln Single submitter ⚠
p.Arg967Trp Single submitter ⚠
p.Arg979Lys Single submitter ⚠
p.Asn322Ser Single submitter ⚠
p.Asn406Asp Single submitter ⚠
p.Asn412Thr Single submitter ⚠
p.Asn459Ser Single submitter ⚠
p.Asn599Ser Single submitter ⚠
p.Asn788Ser Single submitter ⚠
p.Asn999His Single submitter ⚠
p.Asp932Asn Single submitter ⚠
p.Gln1027Leu Single submitter ⚠
p.Gln357Glu Single submitter ⚠
p.Gln393His Single submitter
p.Gln931Arg Single submitter ⚠
p.Glu1074Lys Single submitter ⚠
p.Glu297Lys Single submitter ⚠
p.Glu41Lys Single submitter ⚠
p.Glu601Lys Single submitter ⚠
p.Glu91Gly Single submitter ⚠
p.Glu990Asp Single submitter ⚠
p.Gly227Val Single submitter
p.Gly381Arg Single submitter ⚠
p.Gly503Ser Single submitter ⚠
p.Gly512Arg Single submitter ⚠
p.Gly593Trp Single submitter ⚠
p.Gly704Val Single submitter ⚠
p.Gly824Cys Single submitter ⚠
p.Gly922Cys Single submitter ⚠
p.Gly927Ser Single submitter ⚠
p.His125Pro Single submitter ⚠
p.His594Leu Single submitter ⚠
p.Ile1057Val Single submitter ⚠
p.Ile281Val Single submitter ⚠
p.Ile485Thr Single submitter ⚠
p.Ile528Val Single submitter ⚠
p.Leu140Val Single submitter
p.Leu433Arg Single submitter ⚠
p.Leu553Arg Single submitter ⚠
p.Leu707Phe Single submitter ⚠
p.Leu707Val Single submitter ⚠
p.Leu794Phe Single submitter ⚠
p.Leu975Phe Single submitter ⚠
p.Lys1082Asn Single submitter ⚠
p.Lys306Arg Single submitter ⚠
p.Lys597Arg Single submitter ⚠
p.Lys661Gln Single submitter ⚠
p.Lys767Arg Single submitter ⚠
p.Lys847Asn Single submitter ⚠
p.Lys850Gln Single submitter ⚠
p.Lys976Arg Single submitter ⚠
p.Met1049Arg Single submitter ⚠
p.Met166Val Single submitter ⚠
p.Met364Thr Single submitter ⚠
p.Phe1098Leu Single submitter ⚠
p.Phe315Leu Single submitter ⚠
p.Phe49Leu Single submitter ⚠
p.Phe816Ser Single submitter ⚠
p.Pro1113Ala Single submitter ⚠
p.Pro346Leu Single submitter ⚠
p.Pro446Leu Single submitter ⚠
p.Pro488His Single submitter ⚠
p.Pro506Ser Single submitter ⚠
p.Pro627Ser Single submitter ⚠
p.Pro630Ser Single submitter ⚠
p.Pro655Ser Single submitter ⚠
p.Pro712Ala Single submitter ⚠
p.Pro712Arg Single submitter ⚠
p.Pro712Ser Single submitter ⚠
p.Pro727His Single submitter ⚠
p.Pro753Thr Single submitter ⚠
p.Pro754Arg Single submitter ⚠
p.Pro804Arg Single submitter ⚠
p.Pro804His Single submitter ⚠
p.Pro805Arg Single submitter ⚠
p.Pro805Leu Single submitter ⚠
p.Pro80Leu Single submitter ⚠
p.Pro80Ser Single submitter ⚠
p.Pro953Leu Single submitter ⚠
p.Ser256Cys Single submitter ⚠
p.Ser571Phe Single submitter ⚠
p.Ser611Gly Single submitter ⚠
p.Ser620Ile Single submitter ⚠
p.Ser772Thr Single submitter ⚠
p.Ser858Asn Single submitter ⚠
p.Ser92Asn Single submitter ⚠
p.Thr316Asn Single submitter ⚠
p.Thr475Ala Single submitter ⚠
p.Thr475Met Single submitter ⚠
p.Thr523Arg Single submitter ⚠
p.Thr527Ala Single submitter ⚠
p.Thr581Ser Single submitter ⚠
p.Thr629Asn Single submitter ⚠
p.Thr643Met Single submitter ⚠
p.Thr675Ile Single submitter ⚠
p.Thr680Ser Single submitter ⚠
p.Thr719Ile Single submitter ⚠
p.Thr782Met Single submitter ⚠
p.Tyr416Cys Single submitter ⚠
p.Val117Ile Single submitter ⚠
p.Val120Leu Single submitter ⚠
p.Val323Ile Single submitter ⚠
p.Val363Ile Single submitter ⚠
p.Val409Ala Single submitter ⚠
p.Val409Leu Single submitter ⚠
p.Val409Met Single submitter ⚠
p.Val578Ala Single submitter ⚠
p.Val578Phe Single submitter ⚠
p.Val663Met Single submitter ⚠
p.Val669Leu Single submitter ⚠
p.Val901Leu Single submitter ⚠
p.Val969Ala Single submitter ⚠
p.Val969Leu Single submitter ⚠
p.Val97Ile Single submitter ⚠