USP39 — 65 ClinVar variants
All ClinVar germline USP39 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
2 Likely benign · 63 Uncertain significance
Full USP39 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP39 p.Ala367Ser Uncertain significance Single submitter
- USP39 p.Ala40Val Uncertain significance Single submitter
- USP39 p.Ala41Glu Uncertain significance Single submitter
- USP39 p.Arg103Cys Uncertain significance Single submitter
- USP39 p.Arg14Pro Uncertain significance Single submitter
- USP39 p.Arg22Gly Uncertain significance Single submitter
- USP39 p.Arg440Cys Uncertain significance Single submitter
- USP39 p.Arg515Gly Uncertain significance Single submitter
- USP39 p.Arg52Pro Uncertain significance Single submitter
- USP39 p.Asn461Tyr Uncertain significance Single submitter
- USP39 p.Asn557Asp Uncertain significance Single submitter
- USP39 p.Asn557Ser Uncertain significance Single submitter
- USP39 p.Asn561Asp Uncertain significance Single submitter
- USP39 p.Gln144His Uncertain significance Single submitter
- USP39 p.Glu511Gln Uncertain significance Single submitter
- USP39 p.Glu55Ala Uncertain significance Single submitter
- USP39 p.Glu8Gly Uncertain significance Single submitter
- USP39 p.Gly11Ser Uncertain significance Single submitter
- USP39 p.Gly45Asp Uncertain significance Single submitter
- USP39 p.Gly564Arg Uncertain significance Single submitter
- USP39 p.His375Arg Uncertain significance Single submitter
- USP39 p.Ile189Thr Uncertain significance Single submitter
- USP39 p.Ile262Val Uncertain significance Single submitter
- USP39 p.Ile344Val Uncertain significance Single submitter
- USP39 p.Lys207Asn Uncertain significance Single submitter
- USP39 p.Lys263Arg Uncertain significance Single submitter
- USP39 p.Lys315Arg Uncertain significance Single submitter
- USP39 p.Lys338Arg Uncertain significance Single submitter
- USP39 p.Phe69Val Uncertain significance Single submitter
- USP39 p.Pro63Arg Uncertain significance Single submitter
- USP39 p.Pro68Gln Uncertain significance Single submitter
- USP39 p.Ser42Arg Uncertain significance Single submitter
- USP39 p.Ser46Thr Uncertain significance Single submitter
- USP39 p.Ser58Ile Uncertain significance Single submitter
- USP39 p.Thr13Ile Uncertain significance Single submitter
- USP39 p.Thr198Ile Uncertain significance Single submitter
- USP39 p.Thr310Ile Uncertain significance Single submitter
- USP39 p.Thr343Ser Uncertain significance Single submitter
- USP39 p.Thr535Ala Uncertain significance Single submitter
- USP39 p.Tyr252Cys Uncertain significance Single submitter
- USP39 p.Tyr497Cys Uncertain significance Single submitter
- USP39 p.Val464Ile Uncertain significance Single submitter
- USP39 p.Val50Ala Uncertain significance Single submitter
- USP39 p.Val78Ile Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- USP39 p.Arg14Cys Uncertain significance Single submitter
- USP39 p.Arg288Gln Uncertain significance Single submitter
- USP39 p.Arg49Cys Uncertain significance Single submitter
- USP39 p.Arg76Cys Uncertain significance Single submitter
- USP39 p.Gln442His Uncertain significance Single submitter
- USP39 p.Glu37Val Uncertain significance Single submitter
- USP39 p.Glu511Lys Uncertain significance Single submitter
- USP39 p.Glu53Gln Uncertain significance Single submitter
- USP39 p.Gly11Cys Uncertain significance Single submitter
- USP39 p.His331Gln Uncertain significance Single submitter
- USP39 p.Lys51Asn Uncertain significance Single submitter
- USP39 p.Met389Ile Uncertain significance Single submitter
- USP39 p.Ser25Phe Uncertain significance Single submitter
- USP39 p.Ser2Phe Uncertain significance Single submitter
- USP39 p.Thr535Ile Uncertain significance Single submitter
- USP39 p.Val320Phe Uncertain significance Single submitter
- USP39 p.Val478Met Uncertain significance Single submitter
All USP39 variants
Uncertain significance 63
- p.Ala367Ser Single submitter ⚠
- p.Ala40Val Single submitter ⚠
- p.Ala41Glu Single submitter ⚠
- p.Arg103Cys Single submitter ⚠
- p.Arg14Cys Single submitter ⚠
- p.Arg14Pro Single submitter ⚠
- p.Arg22Gly Single submitter ⚠
- p.Arg288Gln Single submitter ⚠
- p.Arg440Cys Single submitter ⚠
- p.Arg49Cys Single submitter ⚠
- p.Arg515Gly Single submitter ⚠
- p.Arg52Pro Single submitter ⚠
- p.Arg76Cys Single submitter ⚠
- p.Asn461Tyr Single submitter ⚠
- p.Asn557Asp Single submitter ⚠
- p.Asn557Ser Single submitter ⚠
- p.Asn561Asp Single submitter ⚠
- p.Gln144His Single submitter ⚠
- p.Gln442His Single submitter ⚠
- p.Glu37Val Single submitter ⚠
- p.Glu511Gln Single submitter ⚠
- p.Glu511Lys Single submitter ⚠
- p.Glu53Gln Single submitter ⚠
- p.Glu55Ala Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly11Cys Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly45Asp Single submitter ⚠
- p.Gly564Arg Single submitter ⚠
- p.His331Gln Single submitter ⚠
- p.His375Arg Single submitter ⚠
- p.Ile189Thr Single submitter ⚠
- p.Ile262Val Single submitter ⚠
- p.Ile344Val Single submitter ⚠
- p.Lys207Asn Single submitter ⚠
- p.Lys263Arg Single submitter ⚠
- p.Lys315Arg Single submitter ⚠
- p.Lys338Arg Single submitter ⚠
- p.Lys51Asn Single submitter ⚠
- p.Met389Ile Single submitter ⚠
- p.Phe69Val Single submitter ⚠
- p.Pro63Arg Single submitter ⚠
- p.Pro68Gln Single submitter ⚠
- p.Ser25Phe Single submitter ⚠
- p.Ser2Phe Single submitter ⚠
- p.Ser42Arg Single submitter ⚠
- p.Ser46Thr Single submitter ⚠
- p.Ser58Ile Single submitter ⚠
- p.Thr13Ile Single submitter ⚠
- p.Thr190= Single submitter
- p.Thr198Ile Single submitter ⚠
- p.Thr198Pro Single submitter
- p.Thr310Ile Single submitter ⚠
- p.Thr343Ser Single submitter ⚠
- p.Thr535Ala Single submitter ⚠
- p.Thr535Ile Single submitter ⚠
- p.Tyr252Cys Single submitter ⚠
- p.Tyr497Cys Single submitter ⚠
- p.Val320Phe Single submitter ⚠
- p.Val464Ile Single submitter ⚠
- p.Val478Met Single submitter ⚠
- p.Val50Ala Single submitter ⚠
- p.Val78Ile Single submitter ⚠