USP4 — 125 ClinVar variants
All ClinVar germline USP4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 113 flagged for review →
2 Benign · 9 Likely benign · 114 Uncertain significance
Full USP4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 113
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 90
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP4 p.Ala100Glu Uncertain significance Single submitter
- USP4 p.Ala100Val Uncertain significance Single submitter
- USP4 p.Ala177Val Uncertain significance Single submitter
- USP4 p.Ala324Val Uncertain significance Single submitter
- USP4 p.Ala371Thr Uncertain significance Single submitter
- USP4 p.Ala383Thr Uncertain significance Single submitter
- USP4 p.Ala648Pro Uncertain significance Single submitter
- USP4 p.Ala724Gly Uncertain significance Single submitter
- USP4 p.Ala739Val Uncertain significance Single submitter
- USP4 p.Arg170Trp Uncertain significance Single submitter
- USP4 p.Arg278Ser Uncertain significance Single submitter
- USP4 p.Arg373His Uncertain significance Single submitter
- USP4 p.Arg373Leu Uncertain significance Single submitter
- USP4 p.Arg411Trp Uncertain significance Single submitter
- USP4 p.Arg559Gln Uncertain significance Single submitter
- USP4 p.Arg747Gln Uncertain significance Single submitter
- USP4 p.Arg827Cys Uncertain significance Single submitter
- USP4 p.Arg827His Uncertain significance Single submitter
- USP4 p.Asn174Ser Uncertain significance Single submitter
- USP4 p.Asn288Ser Uncertain significance Single submitter
- USP4 p.Asn58Ser Uncertain significance Single submitter
- USP4 p.Asn71Thr Uncertain significance Single submitter
- USP4 p.Asp625Gly Uncertain significance Single submitter
- USP4 p.Asp726Asn Uncertain significance Single submitter
- USP4 p.Asp925Glu Uncertain significance Single submitter
- USP4 p.Cys958Tyr Uncertain significance Single submitter
- USP4 p.Gln227Arg Uncertain significance Single submitter
- USP4 p.Gln290Arg Uncertain significance Single submitter
- USP4 p.Gln667Glu Uncertain significance Single submitter
- USP4 p.Gln950Glu Uncertain significance Single submitter
- USP4 p.Gln950His Uncertain significance Single submitter
- USP4 p.Glu134Lys Uncertain significance Single submitter
- USP4 p.Glu520Lys Uncertain significance Single submitter
- USP4 p.Glu662Lys Uncertain significance Single submitter
- USP4 p.Glu691Asp Uncertain significance Single submitter
- USP4 p.Glu757Lys Uncertain significance Single submitter
- USP4 p.Gly275Arg Uncertain significance Single submitter
- USP4 p.Gly453Asp Uncertain significance Single submitter
- USP4 p.Gly453Val Uncertain significance Single submitter
- USP4 p.Gly513Arg Uncertain significance Single submitter
- USP4 p.Gly574Ser Uncertain significance Single submitter
- USP4 p.Gly681Glu Uncertain significance Single submitter
- USP4 p.His155Arg Uncertain significance Single submitter
- USP4 p.His296Arg Uncertain significance Single submitter
- USP4 p.His406Arg Uncertain significance Single submitter
- USP4 p.His666Gln Uncertain significance Single submitter
- USP4 p.His794Arg Uncertain significance Single submitter
- USP4 p.His824Tyr Uncertain significance Single submitter
- USP4 p.Ile117Val Uncertain significance Single submitter
- USP4 p.Ile351Ser Uncertain significance Single submitter
- USP4 p.Ile868Val Uncertain significance Single submitter
- USP4 p.Leu105Ile Uncertain significance Single submitter
- USP4 p.Leu522Val Uncertain significance Single submitter
- USP4 p.Leu711Phe Uncertain significance Single submitter
- USP4 p.Leu729Pro Uncertain significance Single submitter
- USP4 p.Leu730Phe Uncertain significance Single submitter
- USP4 p.Leu825Phe Uncertain significance Single submitter
- USP4 p.Leu867Val Uncertain significance Single submitter
- USP4 p.Lys132Ile Uncertain significance Single submitter
- USP4 p.Met24Val Uncertain significance Single submitter
- USP4 p.Met557Ile Uncertain significance Single submitter
- USP4 p.Met557Val Uncertain significance Single submitter
- USP4 p.Met56Ile Uncertain significance Single submitter
- USP4 p.Met960Thr Uncertain significance Single submitter
- USP4 p.Pro643Leu Uncertain significance Single submitter
- USP4 p.Ser157Cys Uncertain significance Single submitter
- USP4 p.Ser254Leu Uncertain significance Single submitter
- USP4 p.Ser445Cys Uncertain significance Single submitter
- USP4 p.Ser569Asn Uncertain significance Single submitter
- USP4 p.Ser575Leu Uncertain significance Single submitter
- USP4 p.Ser680Gly Uncertain significance Single submitter
- USP4 p.Ser690Asn Uncertain significance Single submitter
- USP4 p.Ser744Arg Uncertain significance Single submitter
- USP4 p.Ser764Thr Uncertain significance Single submitter
- USP4 p.Thr149Ala Uncertain significance Single submitter
- USP4 p.Thr15Ile Uncertain significance Single submitter
- USP4 p.Thr15Ser Uncertain significance Single submitter
- USP4 p.Thr243Ala Uncertain significance Single submitter
- USP4 p.Thr774Asn Uncertain significance Single submitter
- USP4 p.Thr774Ser Uncertain significance Single submitter
- USP4 p.Thr787Ala Uncertain significance Single submitter
- USP4 p.Tyr252Cys Uncertain significance Single submitter
- USP4 p.Tyr355Cys Uncertain significance Single submitter
- USP4 p.Tyr417Cys Uncertain significance Single submitter
- USP4 p.Tyr916Ser Uncertain significance Single submitter
- USP4 p.Tyr920Cys Uncertain significance Single submitter
- USP4 p.Val509Leu Uncertain significance Single submitter
- USP4 p.Val712Ala Uncertain significance Single submitter
- USP4 p.Val870Met Uncertain significance Single submitter
- USP4 p.Val902Met Uncertain significance Single submitter
Predictors split 23
The independent predictors disagree with each other — read with care.
- USP4 p.Tyr630Cys Likely benign Multiple submitters
- USP4 p.Ala205Thr Uncertain significance Single submitter
- USP4 p.Ala876Asp Uncertain significance Single submitter
- USP4 p.Arg170Gln Uncertain significance Single submitter
- USP4 p.Arg179His Uncertain significance Single submitter
- USP4 p.Arg381Ser Uncertain significance Single submitter
- USP4 p.Arg506His Uncertain significance Single submitter
- USP4 p.Arg626Pro Uncertain significance Single submitter
- USP4 p.Arg629His Uncertain significance Single submitter
- USP4 p.Arg923Gln Uncertain significance Single submitter
- USP4 p.Asp147His Uncertain significance Single submitter
- USP4 p.Asp517Asn Uncertain significance Single submitter
- USP4 p.Glu166Lys Uncertain significance Single submitter
- USP4 p.Glu760Lys Uncertain significance Single submitter
- USP4 p.Glu90Asp Uncertain significance Single submitter
- USP4 p.Glu99Lys Uncertain significance Single submitter
- USP4 p.Gly222Asp Uncertain significance Single submitter
- USP4 p.Gly73Glu Uncertain significance Single submitter
- USP4 p.Leu23Phe Uncertain significance Single submitter
- USP4 p.Leu706Val Uncertain significance Single submitter
- USP4 p.Thr323Ser Uncertain significance Single submitter
- USP4 p.Thr717Ile Uncertain significance Single submitter
- USP4 p.Val842Ile Uncertain significance Single submitter
All USP4 variants
Benign 2
- p.Ile846Val Multiple submitters
- p.Tyr620Cys Multiple submitters
Likely benign 9
- p.Pro591= Multiple submitters
- p.Tyr630Cys Multiple submitters ⚠
- p.Ala869= Single submitter
- p.Ile117= Single submitter
- p.Leu358= Single submitter
- p.Ser946Gly Single submitter
- p.Thr98Ala Single submitter
- p.Val841= Single submitter
- p.Val855= Single submitter
Uncertain significance 114
- p.Ala100Glu Single submitter ⚠
- p.Ala100Val Single submitter ⚠
- p.Ala177Val Single submitter ⚠
- p.Ala205Thr Single submitter ⚠
- p.Ala324Val Single submitter ⚠
- p.Ala371Thr Single submitter ⚠
- p.Ala383Thr Single submitter ⚠
- p.Ala648Pro Single submitter ⚠
- p.Ala724Gly Single submitter ⚠
- p.Ala739Val Single submitter ⚠
- p.Ala876Asp Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg170Trp Single submitter ⚠
- p.Arg179His Single submitter ⚠
- p.Arg278Ser Single submitter ⚠
- p.Arg373His Single submitter ⚠
- p.Arg373Leu Single submitter ⚠
- p.Arg381Ser Single submitter ⚠
- p.Arg411Trp Single submitter ⚠
- p.Arg506His Single submitter ⚠
- p.Arg559Gln Single submitter ⚠
- p.Arg626Pro Single submitter ⚠
- p.Arg629His Single submitter ⚠
- p.Arg747Gln Single submitter ⚠
- p.Arg827Cys Single submitter ⚠
- p.Arg827His Single submitter ⚠
- p.Arg923Gln Single submitter ⚠
- p.Asn174Ser Single submitter ⚠
- p.Asn288Ser Single submitter ⚠
- p.Asn58Ser Single submitter ⚠
- p.Asn71Thr Single submitter ⚠
- p.Asp147His Single submitter ⚠
- p.Asp517Asn Single submitter ⚠
- p.Asp625Gly Single submitter ⚠
- p.Asp726Asn Single submitter ⚠
- p.Asp752His Single submitter
- p.Asp925Glu Single submitter ⚠
- p.Cys958Tyr Single submitter ⚠
- p.Gln227Arg Single submitter ⚠
- p.Gln290Arg Single submitter ⚠
- p.Gln667Glu Single submitter ⚠
- p.Gln950Glu Single submitter ⚠
- p.Gln950His Single submitter ⚠
- p.Glu134Lys Single submitter ⚠
- p.Glu166Lys Single submitter ⚠
- p.Glu520Lys Single submitter ⚠
- p.Glu662Lys Single submitter ⚠
- p.Glu691Asp Single submitter ⚠
- p.Glu757Lys Single submitter ⚠
- p.Glu760Lys Single submitter ⚠
- p.Glu90Asp Single submitter ⚠
- p.Glu99Lys Single submitter ⚠
- p.Gly222Asp Single submitter ⚠
- p.Gly275Arg Single submitter ⚠
- p.Gly453Asp Single submitter ⚠
- p.Gly453Val Single submitter ⚠
- p.Gly513Arg Single submitter ⚠
- p.Gly574Ser Single submitter ⚠
- p.Gly681Glu Single submitter ⚠
- p.Gly73Glu Single submitter ⚠
- p.His155Arg Single submitter ⚠
- p.His296Arg Single submitter ⚠
- p.His406Arg Single submitter ⚠
- p.His666Gln Single submitter ⚠
- p.His794Arg Single submitter ⚠
- p.His824Tyr Single submitter ⚠
- p.Ile117Val Single submitter ⚠
- p.Ile351Ser Single submitter ⚠
- p.Ile868Val Single submitter ⚠
- p.Leu105Ile Single submitter ⚠
- p.Leu23Phe Single submitter ⚠
- p.Leu522Val Single submitter ⚠
- p.Leu706Val Single submitter ⚠
- p.Leu711Phe Single submitter ⚠
- p.Leu729Pro Single submitter ⚠
- p.Leu730Phe Single submitter ⚠
- p.Leu825Phe Single submitter ⚠
- p.Leu867Val Single submitter ⚠
- p.Lys132Ile Single submitter ⚠
- p.Met24Val Single submitter ⚠
- p.Met557Ile Single submitter ⚠
- p.Met557Val Single submitter ⚠
- p.Met56Ile Single submitter ⚠
- p.Met960Thr Single submitter ⚠
- p.Pro510Leu Single submitter
- p.Pro643Leu Single submitter ⚠
- p.Ser157Cys Single submitter ⚠
- p.Ser254Leu Single submitter ⚠
- p.Ser445Cys Single submitter ⚠
- p.Ser569Asn Single submitter ⚠
- p.Ser575Leu Single submitter ⚠
- p.Ser680Gly Single submitter ⚠
- p.Ser690Asn Single submitter ⚠
- p.Ser744Arg Single submitter ⚠
- p.Ser764Thr Single submitter ⚠
- p.Thr149Ala Single submitter ⚠
- p.Thr15Ile Single submitter ⚠
- p.Thr15Ser Single submitter ⚠
- p.Thr243Ala Single submitter ⚠
- p.Thr323Ser Single submitter ⚠
- p.Thr717Ile Single submitter ⚠
- p.Thr774Asn Single submitter ⚠
- p.Thr774Ser Single submitter ⚠
- p.Thr787Ala Single submitter ⚠
- p.Tyr252Cys Single submitter ⚠
- p.Tyr355Cys Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Tyr916Ser Single submitter ⚠
- p.Tyr920Cys Single submitter ⚠
- p.Val509Leu Single submitter ⚠
- p.Val712Ala Single submitter ⚠
- p.Val842Ile Single submitter ⚠
- p.Val870Met Single submitter ⚠
- p.Val902Met Single submitter ⚠