USP5 — 79 ClinVar variants
All ClinVar germline USP5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
5 Benign · 2 Likely benign · 72 Uncertain significance
Full USP5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- USP5 p.Ala495Thr Uncertain significance Single submitter
- USP5 p.Ala549Val Uncertain significance Single submitter
- USP5 p.Ala718Thr Uncertain significance Single submitter
- USP5 p.Ala780Ser Uncertain significance Single submitter
- USP5 p.Arg174Trp Uncertain significance Single submitter
- USP5 p.Arg303Gln Uncertain significance Single submitter
- USP5 p.Arg510Gln Uncertain significance Single submitter
- USP5 p.Arg738Gln Uncertain significance Single submitter
- USP5 p.Arg754Trp Uncertain significance Single submitter
- USP5 p.Arg778Cys Uncertain significance Single submitter
- USP5 p.Arg77Gln Uncertain significance Single submitter
- USP5 p.Arg93Gln Uncertain significance Single submitter
- USP5 p.Arg93Gly Uncertain significance Single submitter
- USP5 p.Arg98Trp Uncertain significance Single submitter
- USP5 p.Asn431Ser Uncertain significance Single submitter
- USP5 p.Asn63Ser Uncertain significance Single submitter
- USP5 p.Asp117Glu Uncertain significance Single submitter
- USP5 p.Asp141Ala Uncertain significance Single submitter
- USP5 p.Asp282Asn Uncertain significance Single submitter
- USP5 p.Asp721Asn Uncertain significance Single submitter
- USP5 p.Gln185Arg Uncertain significance Single submitter
- USP5 p.Gly106Arg Uncertain significance Single submitter
- USP5 p.Gly629Val Uncertain significance Single submitter
- USP5 p.Ile784Val Uncertain significance Single submitter
- USP5 p.Leu320Met Uncertain significance Single submitter
- USP5 p.Leu4Pro Uncertain significance Single submitter
- USP5 p.Leu4Val Uncertain significance Single submitter
- USP5 p.Leu766Arg Uncertain significance Single submitter
- USP5 p.Leu847Pro Uncertain significance Single submitter
- USP5 p.Lys509Gln Uncertain significance Single submitter
- USP5 p.Lys516Asn Uncertain significance Single submitter
- USP5 p.Lys80Glu Uncertain significance Single submitter
- USP5 p.Lys845Arg Uncertain significance Single submitter
- USP5 p.Met493Val Uncertain significance Single submitter
- USP5 p.Met670Thr Uncertain significance Single submitter
- USP5 p.Met815Ile Uncertain significance Single submitter
- USP5 p.Phe114Cys Uncertain significance Single submitter
- USP5 p.Pro394Leu Uncertain significance Single submitter
- USP5 p.Pro394Thr Uncertain significance Single submitter
- USP5 p.Pro609Ser Uncertain significance Single submitter
- USP5 p.Pro615Ala Uncertain significance Single submitter
- USP5 p.Ser564Thr Uncertain significance Single submitter
- USP5 p.Thr605Ile Uncertain significance Single submitter
- USP5 p.Thr651Ile Uncertain significance Single submitter
- USP5 p.Thr680Met Uncertain significance Single submitter
- USP5 p.Tyr389Cys Uncertain significance Single submitter
- USP5 p.Tyr536Cys Uncertain significance Single submitter
- USP5 p.Tyr678Cys Uncertain significance Single submitter
- USP5 p.Tyr851Cys Uncertain significance Single submitter
- USP5 p.Val173Glu Uncertain significance Single submitter
- USP5 p.Val788Leu Uncertain significance Single submitter
- USP5 p.Val790Leu Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- USP5 p.Arg133Trp Uncertain significance Single submitter
- USP5 p.Arg174Gln Uncertain significance Single submitter
- USP5 p.Arg674Cys Uncertain significance Single submitter
- USP5 p.Arg68Gln Uncertain significance Single submitter
- USP5 p.Arg74Trp Uncertain significance Single submitter
- USP5 p.Arg75Trp Uncertain significance Single submitter
- USP5 p.Asn230Ser Uncertain significance Single submitter
- USP5 p.Gly604Ser Uncertain significance Single submitter
- USP5 p.Gly712Trp Uncertain significance Single submitter
- USP5 p.His72Asn Uncertain significance Single submitter
- USP5 p.Ile251Val Uncertain significance Single submitter
- USP5 p.Lys64Asn Uncertain significance Single submitter
- USP5 p.Pro520Ser Uncertain significance Single submitter
- USP5 p.Pro723Thr Uncertain significance Single submitter
- USP5 p.Val583Ala Uncertain significance Single submitter
All USP5 variants
Benign 5
Likely benign 2
- p.Lys20= Single submitter
- p.Pro79Leu Single submitter
Uncertain significance 72
- p.Ala495Thr Single submitter ⚠
- p.Ala549Val Single submitter ⚠
- p.Ala718Thr Single submitter ⚠
- p.Ala780Ser Single submitter ⚠
- p.Arg133Trp Single submitter ⚠
- p.Arg174Gln Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg303Gln Single submitter ⚠
- p.Arg510Gln Single submitter ⚠
- p.Arg674Cys Single submitter ⚠
- p.Arg674His Single submitter
- p.Arg68Gln Single submitter ⚠
- p.Arg738Gln Single submitter ⚠
- p.Arg74Trp Single submitter ⚠
- p.Arg754Trp Single submitter ⚠
- p.Arg75Trp Single submitter ⚠
- p.Arg778Cys Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Arg93Gln Single submitter ⚠
- p.Arg93Gly Single submitter ⚠
- p.Arg98Trp Single submitter ⚠
- p.Asn230Ser Single submitter ⚠
- p.Asn431Ser Single submitter ⚠
- p.Asn63Ser Single submitter ⚠
- p.Asn750Asp Single submitter
- p.Asp117Glu Single submitter ⚠
- p.Asp141Ala Single submitter ⚠
- p.Asp282Asn Single submitter ⚠
- p.Asp721Asn Single submitter ⚠
- p.Gln185Arg Single submitter ⚠
- p.Gly106Arg Single submitter ⚠
- p.Gly422Ser Single submitter
- p.Gly604Ser Single submitter ⚠
- p.Gly610Arg Single submitter
- p.Gly629Val Single submitter ⚠
- p.Gly712Trp Single submitter ⚠
- p.His72Asn Single submitter ⚠
- p.Ile251Val Single submitter ⚠
- p.Ile784Val Single submitter ⚠
- p.Leu320Met Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Leu4Val Single submitter ⚠
- p.Leu580Phe Single submitter
- p.Leu766Arg Single submitter ⚠
- p.Leu847Pro Single submitter ⚠
- p.Lys509Gln Single submitter ⚠
- p.Lys516Asn Single submitter ⚠
- p.Lys64Asn Single submitter ⚠
- p.Lys80Glu Single submitter ⚠
- p.Lys845Arg Single submitter ⚠
- p.Met493Val Single submitter ⚠
- p.Met670Thr Single submitter ⚠
- p.Met815Ile Single submitter ⚠
- p.Phe114Cys Single submitter ⚠
- p.Pro394Leu Single submitter ⚠
- p.Pro394Thr Single submitter ⚠
- p.Pro520Ser Single submitter ⚠
- p.Pro609Ser Single submitter ⚠
- p.Pro615Ala Single submitter ⚠
- p.Pro723Thr Single submitter ⚠
- p.Ser564Thr Single submitter ⚠
- p.Thr605Ile Single submitter ⚠
- p.Thr651Ile Single submitter ⚠
- p.Thr680Met Single submitter ⚠
- p.Tyr389Cys Single submitter ⚠
- p.Tyr536Cys Single submitter ⚠
- p.Tyr678Cys Single submitter ⚠
- p.Tyr851Cys Single submitter ⚠
- p.Val173Glu Single submitter ⚠
- p.Val583Ala Single submitter ⚠
- p.Val788Leu Single submitter ⚠
- p.Val790Leu Single submitter ⚠