UXT — 21 ClinVar variants
All ClinVar germline UXT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
21 Uncertain significance
Full UXT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- UXT p.Ala2Ser Uncertain significance Single submitter
- UXT p.Gln29Lys Uncertain significance Single submitter
- UXT p.Glu21Gly Uncertain significance Single submitter
- UXT p.Glu57Gln Uncertain significance Single submitter
- UXT p.Ile131Val Uncertain significance Single submitter
- UXT p.Ile56Leu Uncertain significance Single submitter
- UXT p.Ser123Asn Uncertain significance Single submitter
- UXT p.Ser25Asn Uncertain significance Single submitter
- UXT p.Ser25Gly Uncertain significance Single submitter
- UXT p.Ser65Leu Uncertain significance Single submitter
- UXT p.Thr13Lys Uncertain significance Single submitter
- UXT p.Thr3Ala Uncertain significance Single submitter
- UXT p.Tyr68His Uncertain significance Single submitter
- UXT p.Val79Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All UXT variants
Uncertain significance 21
- c.-9-11C>G Single submitter
- c.-9-17C>T Single submitter
- c.-9-9A>T Single submitter
- p.Ala2Ser Single submitter ⚠
- p.Arg19His Single submitter ⚠
- p.Arg39Gln Single submitter
- p.Gln29Lys Single submitter ⚠
- p.Glu21Gly Single submitter ⚠
- p.Glu57Gln Single submitter ⚠
- p.Ile131Val Single submitter ⚠
- p.Ile56Leu Single submitter ⚠
- p.Phe98Ser Single submitter ⚠
- p.Ser123Asn Single submitter ⚠
- p.Ser25Asn Single submitter ⚠
- p.Ser25Gly Single submitter ⚠
- p.Ser65Leu Single submitter ⚠
- p.Thr13Lys Single submitter ⚠
- p.Thr3Ala Single submitter ⚠
- p.Tyr68His Single submitter ⚠
- p.Val42Ala Single submitter ⚠
- p.Val79Ile Single submitter ⚠