VAMP8 — 14 ClinVar variants
All ClinVar germline VAMP8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 12 flagged for review →
1 Benign · 13 Uncertain significance
Full VAMP8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 12
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VAMP8 p.Arg37Trp Uncertain significance Single submitter
- VAMP8 p.Asn10Ser Uncertain significance Single submitter
- VAMP8 p.Asn40Asp Uncertain significance Single submitter
- VAMP8 p.Asn40Ile Uncertain significance Single submitter
- VAMP8 p.Ile26Val Uncertain significance Single submitter
- VAMP8 p.Ile91Val Uncertain significance Single submitter
- VAMP8 p.Lys75Asn Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All VAMP8 variants
Benign 1
- c.*143T>C Multiple submitters
Uncertain significance 13
- p.Arg12Cys Single submitter ⚠
- p.Arg12Pro Single submitter ⚠
- p.Arg37Trp Single submitter ⚠
- p.Arg45Cys Single submitter ⚠
- p.Asn10Ser Single submitter ⚠
- p.Asn40Asp Single submitter ⚠
- p.Asn40Ile Single submitter ⚠
- p.Glu39Gly Single submitter
- p.Gly38Glu Single submitter ⚠
- p.Ile26Val Single submitter ⚠
- p.Ile91Val Single submitter ⚠
- p.Lys72Glu Single submitter ⚠
- p.Lys75Asn Single submitter ⚠