VASP — 23 ClinVar variants
All ClinVar germline VASP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 20 flagged for review →
1 Benign · 1 Likely benign · 21 Uncertain significance
Full VASP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 20
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 15
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VASP p.Ala112Val Uncertain significance Single submitter
- VASP p.Arg377Gln Uncertain significance Single submitter
- VASP p.Arg68Trp Uncertain significance Single submitter
- VASP p.Glu330Lys Uncertain significance Single submitter
- VASP p.Glu350Asp Uncertain significance Single submitter
- VASP p.Glu350Gly Uncertain significance Single submitter
- VASP p.Gly147Ser Uncertain significance Single submitter
- VASP p.Gly378Ser Uncertain significance Single submitter
- VASP p.Gly94Arg Uncertain significance Single submitter
- VASP p.Gly94Ser Uncertain significance Single submitter
- VASP p.Pro42Leu Uncertain significance Single submitter
- VASP p.Thr4Met Uncertain significance Single submitter
- VASP p.Val362Met Uncertain significance Single submitter
- VASP p.Val36Ile Uncertain significance Single submitter
- VASP p.Val49Ile Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All VASP variants
Benign 1
- p.Ala104Thr Multiple submitters
Likely benign 1
- p.Val67Ile Single submitter
Uncertain significance 21
- p.Ala112Val Single submitter ⚠
- p.Arg10Gln Single submitter ⚠
- p.Arg22Gln Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg68Gln Single submitter ⚠
- p.Arg68Pro Single submitter ⚠
- p.Arg68Trp Single submitter ⚠
- p.Asn45Lys Single submitter
- p.Asn78Lys Single submitter ⚠
- p.Glu330Lys Single submitter ⚠
- p.Glu350Asp Single submitter ⚠
- p.Glu350Gly Single submitter ⚠
- p.Gly147Ser Single submitter ⚠
- p.Gly378Ser Single submitter ⚠
- p.Gly94Arg Single submitter ⚠
- p.Gly94Ser Single submitter ⚠
- p.Pro42Leu Single submitter ⚠
- p.Thr4Met Single submitter ⚠
- p.Val362Met Single submitter ⚠
- p.Val36Ile Single submitter ⚠
- p.Val49Ile Single submitter ⚠