VAT1 — 51 ClinVar variants
All ClinVar germline VAT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 48 flagged for review →
1 Benign · 1 Likely benign · 49 Uncertain significance
Full VAT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 48
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- VAT1 p.Ala33Ser Uncertain significance Single submitter
- VAT1 p.Ala34Asp Uncertain significance Single submitter
- VAT1 p.Ala43Pro Uncertain significance Single submitter
- VAT1 p.Ala73Thr Uncertain significance Single submitter
- VAT1 p.Arg139Leu Uncertain significance Single submitter
- VAT1 p.Arg210His Uncertain significance Single submitter
- VAT1 p.Arg344His Uncertain significance Single submitter
- VAT1 p.Arg82Pro Uncertain significance Single submitter
- VAT1 p.Asn320Ser Uncertain significance Single submitter
- VAT1 p.Asp15Val Uncertain significance Single submitter
- VAT1 p.Asp262Glu Uncertain significance Single submitter
- VAT1 p.Asp3His Uncertain significance Single submitter
- VAT1 p.Gln65Arg Uncertain significance Single submitter
- VAT1 p.Glu213Lys Uncertain significance Single submitter
- VAT1 p.Glu227Lys Uncertain significance Single submitter
- VAT1 p.Glu36Lys Uncertain significance Single submitter
- VAT1 p.Glu376Ala Uncertain significance Single submitter
- VAT1 p.Gly13Arg Uncertain significance Single submitter
- VAT1 p.Gly13Glu Uncertain significance Single submitter
- VAT1 p.Gly200Asp Uncertain significance Single submitter
- VAT1 p.Gly272Ala Uncertain significance Single submitter
- VAT1 p.Gly55Ser Uncertain significance Single submitter
- VAT1 p.Gly58Ser Uncertain significance Single submitter
- VAT1 p.Ile157Asn Uncertain significance Single submitter
- VAT1 p.Leu385Val Uncertain significance Single submitter
- VAT1 p.Lys271Arg Uncertain significance Single submitter
- VAT1 p.Lys378Asn Uncertain significance Single submitter
- VAT1 p.Phe183Val Uncertain significance Single submitter
- VAT1 p.Phe218Cys Uncertain significance Single submitter
- VAT1 p.Pro32Leu Uncertain significance Single submitter
- VAT1 p.Ser222Leu Uncertain significance Single submitter
- VAT1 p.Thr175Ile Uncertain significance Single submitter
- VAT1 p.Tyr177His Uncertain significance Single submitter
- VAT1 p.Tyr245Cys Uncertain significance Single submitter
- VAT1 p.Val283Ile Uncertain significance Single submitter
- VAT1 p.Val335Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- VAT1 p.Arg133Gln Uncertain significance Single submitter
- VAT1 p.Arg210Cys Uncertain significance Single submitter
- VAT1 p.Arg321Trp Uncertain significance Single submitter
- VAT1 p.Glu365Lys Uncertain significance Single submitter
- VAT1 p.Gly329Asp Uncertain significance Single submitter
- VAT1 p.His226Gln Uncertain significance Single submitter
- VAT1 p.Met161Val Uncertain significance Single submitter
- VAT1 p.Met178Ile Uncertain significance Single submitter
- VAT1 p.Met374Ile Uncertain significance Single submitter
- VAT1 p.Thr54Ile Uncertain significance Single submitter
- VAT1 p.Val121Leu Uncertain significance Single submitter
- VAT1 p.Val311Met Uncertain significance Single submitter
All VAT1 variants
Benign 1
- p.Ala39Thr Single submitter
Likely benign 1
- p.Asn350Ser Single submitter
Uncertain significance 49
- p.Ala33Ser Single submitter ⚠
- p.Ala34Asp Single submitter ⚠
- p.Ala43Pro Single submitter ⚠
- p.Ala73Thr Single submitter ⚠
- p.Arg133Gln Single submitter ⚠
- p.Arg139Leu Single submitter ⚠
- p.Arg210Cys Single submitter ⚠
- p.Arg210His Single submitter ⚠
- p.Arg321Trp Single submitter ⚠
- p.Arg344His Single submitter ⚠
- p.Arg82Pro Single submitter ⚠
- p.Asn320Ser Single submitter ⚠
- p.Asp15Val Single submitter ⚠
- p.Asp262Glu Single submitter ⚠
- p.Asp3His Single submitter ⚠
- p.Gln65Arg Single submitter ⚠
- p.Glu213Lys Single submitter ⚠
- p.Glu227Lys Single submitter ⚠
- p.Glu365Lys Single submitter ⚠
- p.Glu36Lys Single submitter ⚠
- p.Glu376Ala Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly13Glu Single submitter ⚠
- p.Gly200Asp Single submitter ⚠
- p.Gly272Ala Single submitter ⚠
- p.Gly329Asp Single submitter ⚠
- p.Gly55Ser Single submitter ⚠
- p.Gly58Ser Single submitter ⚠
- p.His226Gln Single submitter ⚠
- p.Ile157Asn Single submitter ⚠
- p.Leu385Val Single submitter ⚠
- p.Lys271Arg Single submitter ⚠
- p.Lys378Asn Single submitter ⚠
- p.Met161Val Single submitter ⚠
- p.Met178Ile Single submitter ⚠
- p.Met374Ile Single submitter ⚠
- p.Phe183Val Single submitter ⚠
- p.Phe218Cys Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Ser222Leu Single submitter ⚠
- p.Thr175Ile Single submitter ⚠
- p.Thr54Ile Single submitter ⚠
- p.Tyr177His Single submitter ⚠
- p.Tyr245Cys Single submitter ⚠
- p.Tyr285Cys Single submitter
- p.Val121Leu Single submitter ⚠
- p.Val283Ile Single submitter ⚠
- p.Val311Met Single submitter ⚠
- p.Val335Met Single submitter ⚠